A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm
Concurrent use of cocaine and heroin is a major public health issue with no effective relapse prevention treatment currently available. To this purpose, a combination of buprenorphine and naltrexone, a mixed very-low efficacy mu-opioid receptor agonist/kappa-opioid receptor antagonist/nociceptin rec...
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| Format: | Article |
| Language: | English |
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Wiley
2014
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| Online Access: | http://irep.iium.edu.my/35174/ http://irep.iium.edu.my/35174/1/35174.pdf |
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| author | Cordery, Sarah F Taverner, Alistair Ridzwan, Irna Elina Guy, Richard H Delgado-Charro, M Begoña Husbands, Stephen M Bailey, Christopher P |
| author_facet | Cordery, Sarah F Taverner, Alistair Ridzwan, Irna Elina Guy, Richard H Delgado-Charro, M Begoña Husbands, Stephen M Bailey, Christopher P |
| author_sort | Cordery, Sarah F |
| building | IIUM Repository |
| collection | Online Access |
| description | Concurrent use of cocaine and heroin is a major public health issue with no effective relapse prevention treatment currently available. To this purpose, a combination of buprenorphine and naltrexone, a mixed very-low efficacy mu-opioid receptor agonist/kappa-opioid receptor antagonist/nociceptin receptor agonist, was investigated. The tail-withdrawal and the conditioned place preference (CPP) assays in adult Sprague Dawley rats were used to show that naltrexone dose-dependently blocked the mu-opioid receptor agonism of buprenorphine. Furthermore, in the CPP assay, a combination of 0.3 mg/kg buprenorphine and 3.0 mg/kg naltrexone was aversive. A combination of 0.3 mg/kg buprenorphine and 1.0 mg/kg naltrexone was neither rewarding nor aversive, but still possessed mu-opioid receptor antagonist properties. In the CPP extinction and reinstatement method, a combination of 0.3 mg/kg buprenorphine and 1.0 mg/kg naltrexone completely blocked drug-primed reinstatement in cocaine-conditioned rats (conditioned with 3 mg/kg cocaine, drug prime was 3 mg/kg cocaine) and attenuated drug-primed reinstatement in morphine-conditioned rats (conditioned with 5 mg/kg morphine, drug prime was 1.25 mg/kg morphine). These data add to the growing evidence that a buprenorphine/naltrexone combination may be protective against relapse in a polydrug abuse situation. |
| first_indexed | 2025-11-14T15:42:53Z |
| format | Article |
| id | iium-35174 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:42:53Z |
| publishDate | 2014 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-351742018-08-08T04:19:21Z http://irep.iium.edu.my/35174/ A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm Cordery, Sarah F Taverner, Alistair Ridzwan, Irna Elina Guy, Richard H Delgado-Charro, M Begoña Husbands, Stephen M Bailey, Christopher P RM300 Drugs and their action RS Pharmacy and materia medica Concurrent use of cocaine and heroin is a major public health issue with no effective relapse prevention treatment currently available. To this purpose, a combination of buprenorphine and naltrexone, a mixed very-low efficacy mu-opioid receptor agonist/kappa-opioid receptor antagonist/nociceptin receptor agonist, was investigated. The tail-withdrawal and the conditioned place preference (CPP) assays in adult Sprague Dawley rats were used to show that naltrexone dose-dependently blocked the mu-opioid receptor agonism of buprenorphine. Furthermore, in the CPP assay, a combination of 0.3 mg/kg buprenorphine and 3.0 mg/kg naltrexone was aversive. A combination of 0.3 mg/kg buprenorphine and 1.0 mg/kg naltrexone was neither rewarding nor aversive, but still possessed mu-opioid receptor antagonist properties. In the CPP extinction and reinstatement method, a combination of 0.3 mg/kg buprenorphine and 1.0 mg/kg naltrexone completely blocked drug-primed reinstatement in cocaine-conditioned rats (conditioned with 3 mg/kg cocaine, drug prime was 3 mg/kg cocaine) and attenuated drug-primed reinstatement in morphine-conditioned rats (conditioned with 5 mg/kg morphine, drug prime was 1.25 mg/kg morphine). These data add to the growing evidence that a buprenorphine/naltrexone combination may be protective against relapse in a polydrug abuse situation. Wiley 2014-07 Article PeerReviewed application/pdf en http://irep.iium.edu.my/35174/1/35174.pdf Cordery, Sarah F and Taverner, Alistair and Ridzwan, Irna Elina and Guy, Richard H and Delgado-Charro, M Begoña and Husbands, Stephen M and Bailey, Christopher P (2014) A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm. Addiction Biology, 19 (4). pp. 575-586. ISSN 1355-6215 E-ISSN 1369-1600 https://onlinelibrary.wiley.com/toc/13691600/2014/19/4 |
| spellingShingle | RM300 Drugs and their action RS Pharmacy and materia medica Cordery, Sarah F Taverner, Alistair Ridzwan, Irna Elina Guy, Richard H Delgado-Charro, M Begoña Husbands, Stephen M Bailey, Christopher P A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm |
| title | A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm |
| title_full | A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm |
| title_fullStr | A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm |
| title_full_unstemmed | A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm |
| title_short | A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm |
| title_sort | non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigm |
| topic | RM300 Drugs and their action RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/35174/ http://irep.iium.edu.my/35174/ http://irep.iium.edu.my/35174/1/35174.pdf |