Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats.
Introduction: The study was done at the aim to assess the functionality and viability of the β cells of the streptozotocin-induced diabetic rats model following repetitive dosage of administration of ethanolic extracts of Andrographis paniculata. Materials and Methods: The diabetic rats were treated...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine, International Islamic University Malaysia
2010
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| Online Access: | http://irep.iium.edu.my/347/ http://irep.iium.edu.my/347/1/Assessment_on_functionality_and_viability_of_b_cells_%281%29.pdf |
| _version_ | 1848775698001428480 |
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| author | Kasmuri, Abdul Razak Ahmad, Mariam Sadikun, Amirin Asmawi, Mohd Zaini |
| author_facet | Kasmuri, Abdul Razak Ahmad, Mariam Sadikun, Amirin Asmawi, Mohd Zaini |
| author_sort | Kasmuri, Abdul Razak |
| building | IIUM Repository |
| collection | Online Access |
| description | Introduction: The study was done at the aim to assess the functionality and viability of the β cells of the streptozotocin-induced diabetic rats model following repetitive dosage of administration of ethanolic extracts of Andrographis paniculata. Materials and Methods: The diabetic rats were treated with the extracts for fourteen days and at the dose given was 500 mg/kg twice daily. The assessments were made on fasting blood glucose, insulin, and immunohistochemical aspect of β cells before and after treatment.
Results: The results showed that there was a signifi cant reduction on fasting blood glucose levels in metformin, 95% and 50% ethanolic plant extracts-treated groups but on insulin level only 95% and 50% ethanolic extracts-treated
groups gave a signifi cant reduction (p<0.05). Immunohistochemical assessments revealed that all extract
groups and metformin-treated were signifi cantly increased in the population of β cells (p<0.01).
Conclusion: This study revealed that the plant extracts showed an ability to promote the growth or rejuvenate the STZdestructed β cells and in turn lower the blood glucose level. |
| first_indexed | 2025-11-14T14:18:19Z |
| format | Article |
| id | iium-347 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T14:18:19Z |
| publishDate | 2010 |
| publisher | Faculty of Medicine, International Islamic University Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-3472019-01-24T08:23:06Z http://irep.iium.edu.my/347/ Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats. Kasmuri, Abdul Razak Ahmad, Mariam Sadikun, Amirin Asmawi, Mohd Zaini RS Pharmacy and materia medica Introduction: The study was done at the aim to assess the functionality and viability of the β cells of the streptozotocin-induced diabetic rats model following repetitive dosage of administration of ethanolic extracts of Andrographis paniculata. Materials and Methods: The diabetic rats were treated with the extracts for fourteen days and at the dose given was 500 mg/kg twice daily. The assessments were made on fasting blood glucose, insulin, and immunohistochemical aspect of β cells before and after treatment. Results: The results showed that there was a signifi cant reduction on fasting blood glucose levels in metformin, 95% and 50% ethanolic plant extracts-treated groups but on insulin level only 95% and 50% ethanolic extracts-treated groups gave a signifi cant reduction (p<0.05). Immunohistochemical assessments revealed that all extract groups and metformin-treated were signifi cantly increased in the population of β cells (p<0.01). Conclusion: This study revealed that the plant extracts showed an ability to promote the growth or rejuvenate the STZdestructed β cells and in turn lower the blood glucose level. Faculty of Medicine, International Islamic University Malaysia 2010-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/347/1/Assessment_on_functionality_and_viability_of_b_cells_%281%29.pdf Kasmuri, Abdul Razak and Ahmad, Mariam and Sadikun, Amirin and Asmawi, Mohd Zaini (2010) Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats. International Medical Journal Malaysia, 9 (1). pp. 21-26. ISSN 1823-4631 http://iiumedic.com/eimj/v1/?p=149 |
| spellingShingle | RS Pharmacy and materia medica Kasmuri, Abdul Razak Ahmad, Mariam Sadikun, Amirin Asmawi, Mohd Zaini Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats. |
| title | Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats. |
| title_full | Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats. |
| title_fullStr | Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats. |
| title_full_unstemmed | Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats. |
| title_short | Assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats. |
| title_sort | assessment on functionality and viability of β cells following repetitive dosage administration of ethanolic extracts of andrographis paniculata on streptozotocin-induced diabetic rats. |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/347/ http://irep.iium.edu.my/347/ http://irep.iium.edu.my/347/1/Assessment_on_functionality_and_viability_of_b_cells_%281%29.pdf |