A study of Paraoxonase-1 192 gene polymorphism in coronary artery disease
Paraoxonase-1 (PON-1) is an HDL-associated enzyme which has been implicated in the pathogenesis of atherosclerosis by preventing lipid peroxide generation. The population variability in this enzyme activity is attributed to polymorphism in PON-1 gene. Recent studies have suggested that PON-1 Q192R...
| Main Authors: | , , , |
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| Format: | Proceeding Paper |
| Language: | English |
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2013
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| Online Access: | http://irep.iium.edu.my/34291/ http://irep.iium.edu.my/34291/1/poster_abstract_for_MSAB_symposium_2013.jpg |
| _version_ | 1848780888427462656 |
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| author | Muhammad Musa, Nurul Ashikin Abdullah, Nor Zamzila A.Talib, Norlelawati Nik Ahmad, Nik Nur Fatnoon |
| author_facet | Muhammad Musa, Nurul Ashikin Abdullah, Nor Zamzila A.Talib, Norlelawati Nik Ahmad, Nik Nur Fatnoon |
| author_sort | Muhammad Musa, Nurul Ashikin |
| building | IIUM Repository |
| collection | Online Access |
| description | Paraoxonase-1 (PON-1) is an HDL-associated enzyme which has been implicated in the pathogenesis of atherosclerosis by preventing lipid peroxide generation. The population variability in this enzyme activity is attributed to polymorphism in PON-1 gene. Recent studies have suggested that PON-1 Q192R polymorphism is associated with coronary artery disease (CAD) in different ethnic populations. However to this date, there is no such study in Malaysia. The present study looks at PON-1 Q192R gene polymorphism among CAD patients and healthy controls in Kuantan, Pahang. This study consisted of 187 CAD patients and 188 healthy subjects. PON-1 Q192R genotypes were determined by polymerase chain reaction (PCR) and AlwI restriction enzyme digestion. The Q192R polymorphism was significantly associated with CAD (p = 0.004), where the 192R allele was found to be more frequent in CAD patients than controls (0.618 vs 0.513) with QR genotype being the commonest (45.5%), followed by RR (39.0%) and QQ (15.5%) genotypes. In conclusion, the PON-1 Q192R polymorphism is significantly associated with CAD. This finding indicates that this gene variation is a useful genetic marker for CAD in our population. However, a multicentre study may be required to confirm our findings in Malaysian population. |
| first_indexed | 2025-11-14T15:40:49Z |
| format | Proceeding Paper |
| id | iium-34291 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:40:49Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-342912014-01-16T06:14:34Z http://irep.iium.edu.my/34291/ A study of Paraoxonase-1 192 gene polymorphism in coronary artery disease Muhammad Musa, Nurul Ashikin Abdullah, Nor Zamzila A.Talib, Norlelawati Nik Ahmad, Nik Nur Fatnoon RB Pathology Paraoxonase-1 (PON-1) is an HDL-associated enzyme which has been implicated in the pathogenesis of atherosclerosis by preventing lipid peroxide generation. The population variability in this enzyme activity is attributed to polymorphism in PON-1 gene. Recent studies have suggested that PON-1 Q192R polymorphism is associated with coronary artery disease (CAD) in different ethnic populations. However to this date, there is no such study in Malaysia. The present study looks at PON-1 Q192R gene polymorphism among CAD patients and healthy controls in Kuantan, Pahang. This study consisted of 187 CAD patients and 188 healthy subjects. PON-1 Q192R genotypes were determined by polymerase chain reaction (PCR) and AlwI restriction enzyme digestion. The Q192R polymorphism was significantly associated with CAD (p = 0.004), where the 192R allele was found to be more frequent in CAD patients than controls (0.618 vs 0.513) with QR genotype being the commonest (45.5%), followed by RR (39.0%) and QQ (15.5%) genotypes. In conclusion, the PON-1 Q192R polymorphism is significantly associated with CAD. This finding indicates that this gene variation is a useful genetic marker for CAD in our population. However, a multicentre study may be required to confirm our findings in Malaysian population. 2013 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/34291/1/poster_abstract_for_MSAB_symposium_2013.jpg Muhammad Musa, Nurul Ashikin and Abdullah, Nor Zamzila and A.Talib, Norlelawati and Nik Ahmad, Nik Nur Fatnoon (2013) A study of Paraoxonase-1 192 gene polymorphism in coronary artery disease. In: 9th National Biology Symposium, 28-30 May 2013, Thistle Port Dickson Resort, Negeri Sembilan.. (Unpublished) |
| spellingShingle | RB Pathology Muhammad Musa, Nurul Ashikin Abdullah, Nor Zamzila A.Talib, Norlelawati Nik Ahmad, Nik Nur Fatnoon A study of Paraoxonase-1 192 gene polymorphism in coronary artery disease |
| title | A study of Paraoxonase-1 192 gene polymorphism in coronary artery disease |
| title_full | A study of Paraoxonase-1 192 gene polymorphism in coronary artery disease |
| title_fullStr | A study of Paraoxonase-1 192 gene polymorphism in coronary artery disease |
| title_full_unstemmed | A study of Paraoxonase-1 192 gene polymorphism in coronary artery disease |
| title_short | A study of Paraoxonase-1 192 gene polymorphism in coronary artery disease |
| title_sort | study of paraoxonase-1 192 gene polymorphism in coronary artery disease |
| topic | RB Pathology |
| url | http://irep.iium.edu.my/34291/ http://irep.iium.edu.my/34291/1/poster_abstract_for_MSAB_symposium_2013.jpg |