QSAR study of platelet-activating factor (PAF) receptor binding antagonist
The aim of this study was to find the structure activity relationship between the platelet-activating factor (PAF) receptor binding antagonist activity and the psychochemical properties of flavonoids 1-11 by using quantum chemical QSAR approach. The semi-empirical method quantum method was used t...
| Main Authors: | , , |
|---|---|
| Format: | Proceeding Paper |
| Language: | English English English |
| Published: |
2013
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/34147/ http://irep.iium.edu.my/34147/9/QSAR_-_ICBioE2013_proceedings_paper_pp-684-690.pdf http://irep.iium.edu.my/34147/2/Brochure.pdf http://irep.iium.edu.my/34147/3/ICBIOE_2013_Cover_Page_till_Table_of_contents.pdf |
| _version_ | 1848780865210941440 |
|---|---|
| author | Abdullah, Nor Hayati Ibrahim Ali , Noorbatcha Ling, Sui Kiong |
| author_facet | Abdullah, Nor Hayati Ibrahim Ali , Noorbatcha Ling, Sui Kiong |
| author_sort | Abdullah, Nor Hayati |
| building | IIUM Repository |
| collection | Online Access |
| description | The aim of this study was to find the structure activity relationship between the platelet-activating
factor (PAF) receptor binding antagonist activity and the psychochemical properties of flavonoids
1-11 by using quantum chemical QSAR approach. The semi-empirical method quantum method
was used to optimize the molecular structures of the flavanoids and various quantum chemical
descriptors were calculated from the optimized structures. Heuristic and multi-linear regression
methods were used to determine the correlation between the quantum chemical properties and the
experimental PAF receptor binding inhibitory activity. The best correlation equation was obtained
using three descriptors and multi-linear correlation method with R2= 0.9632 |
| first_indexed | 2025-11-14T15:40:27Z |
| format | Proceeding Paper |
| id | iium-34147 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T15:40:27Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-341472014-01-15T02:45:41Z http://irep.iium.edu.my/34147/ QSAR study of platelet-activating factor (PAF) receptor binding antagonist Abdullah, Nor Hayati Ibrahim Ali , Noorbatcha Ling, Sui Kiong TP248.13 Biotechnology The aim of this study was to find the structure activity relationship between the platelet-activating factor (PAF) receptor binding antagonist activity and the psychochemical properties of flavonoids 1-11 by using quantum chemical QSAR approach. The semi-empirical method quantum method was used to optimize the molecular structures of the flavanoids and various quantum chemical descriptors were calculated from the optimized structures. Heuristic and multi-linear regression methods were used to determine the correlation between the quantum chemical properties and the experimental PAF receptor binding inhibitory activity. The best correlation equation was obtained using three descriptors and multi-linear correlation method with R2= 0.9632 2013-07-02 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/34147/9/QSAR_-_ICBioE2013_proceedings_paper_pp-684-690.pdf application/pdf en http://irep.iium.edu.my/34147/2/Brochure.pdf application/pdf en http://irep.iium.edu.my/34147/3/ICBIOE_2013_Cover_Page_till_Table_of_contents.pdf Abdullah, Nor Hayati and Ibrahim Ali , Noorbatcha and Ling, Sui Kiong (2013) QSAR study of platelet-activating factor (PAF) receptor binding antagonist. In: International Conference on Biotechnology Engineering (ICBioE 2013), 2 – 4 Jul 2013, Kuala Lumpur, Malaysia. |
| spellingShingle | TP248.13 Biotechnology Abdullah, Nor Hayati Ibrahim Ali , Noorbatcha Ling, Sui Kiong QSAR study of platelet-activating factor (PAF) receptor binding antagonist |
| title | QSAR study of platelet-activating factor (PAF) receptor binding antagonist |
| title_full | QSAR study of platelet-activating factor (PAF) receptor binding antagonist |
| title_fullStr | QSAR study of platelet-activating factor (PAF) receptor binding antagonist |
| title_full_unstemmed | QSAR study of platelet-activating factor (PAF) receptor binding antagonist |
| title_short | QSAR study of platelet-activating factor (PAF) receptor binding antagonist |
| title_sort | qsar study of platelet-activating factor (paf) receptor binding antagonist |
| topic | TP248.13 Biotechnology |
| url | http://irep.iium.edu.my/34147/ http://irep.iium.edu.my/34147/9/QSAR_-_ICBioE2013_proceedings_paper_pp-684-690.pdf http://irep.iium.edu.my/34147/2/Brochure.pdf http://irep.iium.edu.my/34147/3/ICBIOE_2013_Cover_Page_till_Table_of_contents.pdf |