Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms
Objective: To test direct and indirect antimicrobial properties of α-mangostin towards a number of bacteria and fungi. Methods: The experiment was carried out using broth microdilution and checkerboards methods. Activity of α-mangostin paired with an antibiotic was studied by calculating its fracti...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Coastal Life Medicine Media co., Limited
2014
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/33985/ http://irep.iium.edu.my/33985/1/JCLM_mangostin_direct_and_indirect.pdf |
| _version_ | 1848780837245419520 |
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| author | Syed Ibrahim, Nurul Huda Bakhtiar, M. Taher Darnis, Deny Susanti Mohamed Amiroudine, Mohamed Zaffar Ali Ahmed, Qamar Uddin |
| author_facet | Syed Ibrahim, Nurul Huda Bakhtiar, M. Taher Darnis, Deny Susanti Mohamed Amiroudine, Mohamed Zaffar Ali Ahmed, Qamar Uddin |
| author_sort | Syed Ibrahim, Nurul Huda |
| building | IIUM Repository |
| collection | Online Access |
| description | Objective: To test direct and indirect antimicrobial properties of α-mangostin towards a number of bacteria and fungi.
Methods: The experiment was carried out using broth microdilution and checkerboards methods. Activity of α-mangostin paired with an antibiotic was studied by calculating its fractional inhibitory concentration (FIC).
Results: The activity of all four bacteria towards ampicillin, penicillin G, streptomycin and tetracycline showed no interaction with the combination with α-mangostin where the FIC indexes were between the range of 0.5<FICindex>4. Activity of doxycycline on Pseudomonas aeruginosa fell into other set of range, FICindex≥4 which is an antagonism.
Conclusions: The FIC index is far away in the range. The coupled antibiotic and α-mangostin is considered synergy in action if it lies in FICindex≤0.5 and it was found that the isolated compound, α-mangostin revealed very low synergistic antimicrobial effects when coupled with antibiotics. |
| first_indexed | 2025-11-14T15:40:01Z |
| format | Article |
| id | iium-33985 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:40:01Z |
| publishDate | 2014 |
| publisher | Coastal Life Medicine Media co., Limited |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-339852015-01-29T08:23:58Z http://irep.iium.edu.my/33985/ Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms Syed Ibrahim, Nurul Huda Bakhtiar, M. Taher Darnis, Deny Susanti Mohamed Amiroudine, Mohamed Zaffar Ali Ahmed, Qamar Uddin RS Pharmacy and materia medica Objective: To test direct and indirect antimicrobial properties of α-mangostin towards a number of bacteria and fungi. Methods: The experiment was carried out using broth microdilution and checkerboards methods. Activity of α-mangostin paired with an antibiotic was studied by calculating its fractional inhibitory concentration (FIC). Results: The activity of all four bacteria towards ampicillin, penicillin G, streptomycin and tetracycline showed no interaction with the combination with α-mangostin where the FIC indexes were between the range of 0.5<FICindex>4. Activity of doxycycline on Pseudomonas aeruginosa fell into other set of range, FICindex≥4 which is an antagonism. Conclusions: The FIC index is far away in the range. The coupled antibiotic and α-mangostin is considered synergy in action if it lies in FICindex≤0.5 and it was found that the isolated compound, α-mangostin revealed very low synergistic antimicrobial effects when coupled with antibiotics. Coastal Life Medicine Media co., Limited 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/33985/1/JCLM_mangostin_direct_and_indirect.pdf Syed Ibrahim, Nurul Huda and Bakhtiar, M. Taher and Darnis, Deny Susanti and Mohamed Amiroudine, Mohamed Zaffar Ali and Ahmed, Qamar Uddin (2014) Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms. Journal of Coastal Life Medicine, 2 (1). pp. 70-75. ISSN 2309-6152 (O), 2309-5288 (P) doi:10.12980/JCLM.2.2014J7 |
| spellingShingle | RS Pharmacy and materia medica Syed Ibrahim, Nurul Huda Bakhtiar, M. Taher Darnis, Deny Susanti Mohamed Amiroudine, Mohamed Zaffar Ali Ahmed, Qamar Uddin Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms |
| title | Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms |
| title_full | Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms |
| title_fullStr | Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms |
| title_full_unstemmed | Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms |
| title_short | Direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms |
| title_sort | direct and indirect antimicrobial effects of α-mangostin on pathogenic microorganisms |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/33985/ http://irep.iium.edu.my/33985/ http://irep.iium.edu.my/33985/1/JCLM_mangostin_direct_and_indirect.pdf |