Celecoxib as a neuroprotective agent in chronic cerebral hypoperfusion-induced neurodegeneration in rats
Objectives: Reduced cerebral blood flow (CBF)has been associated with neurodegenerative disorders. Since neuroinflammation is thought to play a significant role in chronic degenerative neurological disorders like Alzheimer's disease, the present study was planned to,assess the neuroprotective...
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| Format: | Proceeding Paper |
| Language: | English English English |
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2013
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| Online Access: | http://irep.iium.edu.my/33808/ http://irep.iium.edu.my/33808/1/Oral_Presentation_Certificate.pdf http://irep.iium.edu.my/33808/2/Abstract.pdf http://irep.iium.edu.my/33808/3/Cover_Page.pdf |
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| author | Saxena, Anil Kumar Mohd Noor, Mohd Fadly A.Talib, Norlelawati |
| author_facet | Saxena, Anil Kumar Mohd Noor, Mohd Fadly A.Talib, Norlelawati |
| author_sort | Saxena, Anil Kumar |
| building | IIUM Repository |
| collection | Online Access |
| description | Objectives: Reduced cerebral blood flow (CBF)has been associated with neurodegenerative disorders. Since neuroinflammation is thought to play a significant role in chronic degenerative neurological disorders like Alzheimer's
disease, the present study was planned to,assess the neuroprotective role of celecoxib in Alzheimer's model of rats(2VO).
Methods:Experimentally,a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent
bilateral occlusion of common carotid arteries (2VO)in rats.
After 1 week of acclimatization,fifteen Sprague Dawley rats weighing 200-250 g were equally divided into three groups. Group A served as - sham control, Group B - 2VO, and Group C - 2VO-C treated daily with celecoxib 50 mg/kg, orally following 2VO. On 8th week, all the rats were euthanized and
the hippocampi were isolated. Viable neuronal cells in the hippocampal CA-1 region were counted and hippocampal COX-2 mRNA expression and prostaglandin E2(PGE-2)levels were estimated.
Results: There was a significant difference in neuronal cell
death, increase in COX-2 mRNA expression and PGE-2 levels in
2VO group as compared to sham control group. In celecoxib-treated 2VO-C rats,the viable neuronal cell count of the
hippocampal CA-l region was significantly higher as compared
to the untreated 2VO group. The hippocampal COX-2 mRNA expression and hippocampal PGE-2 levels were found to be significantly lower in the celecoxib-treated 2VO rats as compared to untreated 2VO rats.
Conclusions: The results indicate that celecoxib could be successfully used in the management of Alzheimer's disease.
No conflict of interest. |
| first_indexed | 2025-11-14T15:39:41Z |
| format | Proceeding Paper |
| id | iium-33808 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T15:39:41Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-338082020-11-09T07:28:54Z http://irep.iium.edu.my/33808/ Celecoxib as a neuroprotective agent in chronic cerebral hypoperfusion-induced neurodegeneration in rats Saxena, Anil Kumar Mohd Noor, Mohd Fadly A.Talib, Norlelawati R Medicine (General) RC321 Neuroscience. Biological psychiatry. Neuropsychiatry RM300 Drugs and their action Objectives: Reduced cerebral blood flow (CBF)has been associated with neurodegenerative disorders. Since neuroinflammation is thought to play a significant role in chronic degenerative neurological disorders like Alzheimer's disease, the present study was planned to,assess the neuroprotective role of celecoxib in Alzheimer's model of rats(2VO). Methods:Experimentally,a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteries (2VO)in rats. After 1 week of acclimatization,fifteen Sprague Dawley rats weighing 200-250 g were equally divided into three groups. Group A served as - sham control, Group B - 2VO, and Group C - 2VO-C treated daily with celecoxib 50 mg/kg, orally following 2VO. On 8th week, all the rats were euthanized and the hippocampi were isolated. Viable neuronal cells in the hippocampal CA-1 region were counted and hippocampal COX-2 mRNA expression and prostaglandin E2(PGE-2)levels were estimated. Results: There was a significant difference in neuronal cell death, increase in COX-2 mRNA expression and PGE-2 levels in 2VO group as compared to sham control group. In celecoxib-treated 2VO-C rats,the viable neuronal cell count of the hippocampal CA-l region was significantly higher as compared to the untreated 2VO group. The hippocampal COX-2 mRNA expression and hippocampal PGE-2 levels were found to be significantly lower in the celecoxib-treated 2VO rats as compared to untreated 2VO rats. Conclusions: The results indicate that celecoxib could be successfully used in the management of Alzheimer's disease. No conflict of interest. 2013-12-08 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/33808/1/Oral_Presentation_Certificate.pdf application/pdf en http://irep.iium.edu.my/33808/2/Abstract.pdf application/pdf en http://irep.iium.edu.my/33808/3/Cover_Page.pdf Saxena, Anil Kumar and Mohd Noor, Mohd Fadly and A.Talib, Norlelawati (2013) Celecoxib as a neuroprotective agent in chronic cerebral hypoperfusion-induced neurodegeneration in rats. In: XX World Congress on Parkinson"s Disease and Related Disorders, 8-11 Dec 2013 , Geneva, Switzerland. (Unpublished) http://www.kenes.com/parkinson |
| spellingShingle | R Medicine (General) RC321 Neuroscience. Biological psychiatry. Neuropsychiatry RM300 Drugs and their action Saxena, Anil Kumar Mohd Noor, Mohd Fadly A.Talib, Norlelawati Celecoxib as a neuroprotective agent in chronic cerebral hypoperfusion-induced neurodegeneration in rats |
| title | Celecoxib as a neuroprotective agent in chronic cerebral hypoperfusion-induced neurodegeneration in rats |
| title_full | Celecoxib as a neuroprotective agent in chronic cerebral hypoperfusion-induced neurodegeneration in rats |
| title_fullStr | Celecoxib as a neuroprotective agent in chronic cerebral hypoperfusion-induced neurodegeneration in rats |
| title_full_unstemmed | Celecoxib as a neuroprotective agent in chronic cerebral hypoperfusion-induced neurodegeneration in rats |
| title_short | Celecoxib as a neuroprotective agent in chronic cerebral hypoperfusion-induced neurodegeneration in rats |
| title_sort | celecoxib as a neuroprotective agent in chronic cerebral hypoperfusion-induced neurodegeneration in rats |
| topic | R Medicine (General) RC321 Neuroscience. Biological psychiatry. Neuropsychiatry RM300 Drugs and their action |
| url | http://irep.iium.edu.my/33808/ http://irep.iium.edu.my/33808/ http://irep.iium.edu.my/33808/1/Oral_Presentation_Certificate.pdf http://irep.iium.edu.my/33808/2/Abstract.pdf http://irep.iium.edu.my/33808/3/Cover_Page.pdf |