Clinicopathological features of homologous recombination deficient epithelial ovarian cancers: sensitivity to PARP inhibitors, platinum and survival

QR Code

Clinicopathological features of homologous recombination deficient epithelial ovarian cancers: sensitivity to PARP inhibitors, platinum and survival

Up to 50% of epithelial ovarian cancers (EOC) display defects in the homologous recombination (HR) pathway. We sought to determine the ramifications of the homologous recombination deficient (HRD) status on the clinicopathological features, chemotherapy response and survival outcomes of EOC patie...

Full description

Bibliographic Details
Main Authors:	Mukhophadyay, Asima, Plummer, Elizabeth R, Elattar, Ahmed, San, SooHoo, Uzir, Bisha Fathamah, Quinn, Jennifer E, Edmondson, Richard J, Curtin, Nicola J, Harriet, Aneke, Maxwell, Perry, McCluggage, W Glenn
Format:	Article
Language:	English
Published:	American Association of Cancer Research 2012
Subjects:	RB Pathology RG Gynecology and obstetrics
Online Access:	http://irep.iium.edu.my/33769/ http://irep.iium.edu.my/33769/1/33769.pdf

Similar Items

Combining PARP inhibition with platinum, ruthenium or gold complexes for cancer therapy
by: Yusoh, Nur Aininie, et al.
Published: (2020)

Clinicopathological and prognostic significance of Ras Association and Pleckstrin Homology domains 1 (RAPH1) in breast cancer
by: Kurozumi, Sasagu, et al.
Published: (2018)

Bioassays activity and FT-IR analysis of clinacanthus nutans (Burm F.) lindau leaves extracts
by: Khatib, Alfi, et al.
Published: (2017)

Short homologies efficiently generate detectable homologous recombination events
by: Osahor, Andrew N., et al.
Published: (2014)

Isolation, characterization and cytotoxic activity of arborinine from glycosmis pentaphylla (Retz.) DC. on human mammary gland adenocarcinoma (MCF7) cell line
by: Mohd Hussain, Nurlaili Najmi, et al.
Published: (2015)

Arborinine from Glycosmis Pentaphylla (retz.) DC induces apoptosis through activation of Caspase-3/7 in human mammary gland Adenocarcinoma (MCF-7) cell line
by: Mohd Hussain, Nurlaili Najmie, et al.
Published: (2016)

Homological and motivic invariants of torsors
by: Tanania, Fabio
Published: (2020)

Low inhibition of alpha-glucosidase and xanthine oxidase activities of ethanol extract of Momordica charantia fruit
by: Khatib, Alfi, et al.
Published: (2017)

Islamic approach in managing stress within study on perceived stress score & academic performance in continuous assessment among third year pharmacy students
by: Soe, May Khin Soe, et al.
Published: (2016)

Potential association of nicotinamide on the telomerase activity and telomere length mediated by PARP-1 mechanism in myeloid cancer
by: Nur Rasyidah Muhammad,, et al.
Published: (2020)

Ethanol induces microglial cell death via the NOX/ROS/PARP/TRPM2 signalling pathway
by: Sha’fie, Muhammad Syahreel Azhad, et al.
Published: (2020)

PARP inhibitor combinations with Olaparib for synergistic efficacy in Olaparib-resistant triple-negative breast cancer cells
by: Yusoh, Nur Aininie
Published: (2023)

Homology modelling and structural analysis of Phytases
by: Noorbatcha, Ibrahim Ali, et al.
Published: (2010)

Evaluation of antioxidants activity of Momordica charantia using LC-MS metabolomics approach
by: Perumal, Vikneswari, et al.
Published: (2017)

Oral cavity non-Hodgkin’s lymphoma: Clinicopathological aspects
by: Shweta N Kalyankar,
Published: (2015)

Correlation of apoptotic related protiens and clinicopathological parameters in liposarcoma
by: Abd Alabbas, Haider K.
Published: (2012)

Clinicopathological Changes in Adjuvant Induced Arthritis in Canine Stifle Joint
by: Ismail, Siti Norhayati
Published: (2001)

Hedgehog pathway proteins and their association with clinicopathological parameters of bladder cancer
by: Mohd Ariffin, Khairunnisa
Published: (2016)

Effects of nicotinamide and nilotinib on telomerase activity and telomere length associated with parp-1 regulation in k562 myeloid cell line
by: Muhammad, Nur Rasyidah
Published: (2023)

Characterization of antioxidant activity of Momordica Charantia fruit by infrared-based fingerprinting
by: Khatib, Alfi, et al.
Published: (2017)

Characterization of antioxidant activity of Momordica charantia fruit by infrared-based fingerprinting
by: Khatib, Alfi, et al.
Published: (2017)

An optimal mesh algorithm for remote protein homology detection
by: M. Abdullah, Firdaus, et al.
Published: (2011)

Clinicopathological and functional significance of RECQL1 helicase in sporadic breast cancers
by: Arora, Arvind, et al.
Published: (2017)

The relationship of P53 gene mutation with clinicopathological characteristic in breast cancer
by: Amrank, Fitreena Anis
Published: (2016)

Clinicopathological characteristics of liposarcoma- ten years experience in a single institution
by: Alduais, Saleh Abdulkadir Saeed
Published: (2023)

Metallointercalator [Ru(dppz)2(PIP)]2+ renders BRCA wild-type triple-negative breast cancer cells hypersensitive to PARP inhibition
by: Yusoh, Nur Aininie, et al.
Published: (2020)

Synergy of ruthenium metallo-intercalator, [Ru(dppz)2(PIP)]2+, with PARP inhibitor Olaparib in non-small cell lung cancer cells
by: Yusoh, Nur Aininie, et al.
Published: (2023)

Effect of combination therapy of ruthenium polypyridyl complex, [Ru(dppz)2(PIP)]2+ and parp inhibitors against several cancer cell lines
by: Yusoh, Nur Aininie
Published: (2020)

Clinicopathological and prognostic significance of mitogen-activated protein kinases (MAPK) in breast cancers
by: Ahmad, Dena Akram Jerjees, et al.
Published: (2016)

The relationship of CDK18 expression in breast cancer to clinicopathological parameters and therapeutic response
by: Barone, Giancarlo, et al.
Published: (2018)

Association between autophagy and KRAS mutation with clinicopathological variables in colorectal cancer patients
by: Awi, Noel Jacques, et al.
Published: (2021)

A hybrid prognostic model for oral cancer based on clinicopathologic and genomic markers
by: Siow, Wee Chang, et al.
Published: (2014)

A clinicopathologic study on triple-negative breast cancer patients: HUSM experience
by: Saidin, Usman Sani
Published: (2011)

The suppression of homologous immunity by soluble adult antigens of Nematospiroides dubius
by: Pritchard, D.I., et al.
Published: (1985)

Homology modeling of Pyranose 2-Oxidase from Phanerochaete Chrysosporium
by: Ibrahim Ali, Noorbatcha, et al.
Published: (2013)

Homology Modeling Of β-Glucuronidases From E. Coli and T. Maritima
by: Noorbatcha, Ibrahim Ali, et al.
Published: (2009)

Homology modelling of Pyranose-2-Oxidase from Phanerochaete Chrysosporium
by: Noorbatcha, Ibrahim Ali, et al.
Published: (2011)

Homology modeling of pyranose 2-oxidase from phanerochaete chrysosporium
by: Ibrahim Ali, Noorbatcha, et al.
Published: (2014)

Streamflow data analysis for flood detection using persistent homology
by: Syed Mohamad Sadiq Syed Musa,, et al.
Published: (2022)

Using a panel of immunomarkers to define homologies in mammalian brains
by: Watson, Charles, et al.
Published: (2010)