The effects of Angiotensin-Converting-Enzyme Inhibitor (Captopril) on Gentamicin Nephrotoxicity in rats
This study was designed to investigate the effects of captopril on gentamicin nephrotoxicity. Six groups of male Wister rats “15 rats each” were used. Group “C”, was given 1ml of normal saline, group “G25” was injected with a single dose of GM (25mg/Kg/day), group “G50” was injected with a single do...
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Research and Reviews (Shastri Educational Trust®)
2013
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| Online Access: | http://irep.iium.edu.my/32886/ http://irep.iium.edu.my/32886/1/The_Effects_of_Angiotensin-Converting-Enzyme_Inhibito.pdf |
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| author | Al-Attiyah, Zainab M Al-Ani, Imad Matloub Dally Abdul-Kareem, Humam N. Matlop, Enas I. |
| author_facet | Al-Attiyah, Zainab M Al-Ani, Imad Matloub Dally Abdul-Kareem, Humam N. Matlop, Enas I. |
| author_sort | Al-Attiyah, Zainab M |
| building | IIUM Repository |
| collection | Online Access |
| description | This study was designed to investigate the effects of captopril on gentamicin nephrotoxicity. Six groups of male Wister rats “15 rats each” were used. Group “C”, was given 1ml of normal saline, group “G25” was injected with a single dose of GM (25mg/Kg/day), group “G50” was injected with a single dose of GM (50mg/Kg/day), group “Cp2” was given a single oral dose of captopril (2mg/day), group “Cp2+G25” was injected with a single dose of GM (25mg/Kg/day) and a single oral dose of captopril (2mg/day), group “Cp2+G50” was injected with a single dose of GM (50mg/Kg/day) and a single oral dose of captopril (2mg/day).
Treatment continued daily for 15 days; analysis was performed on days 5, 10 and 15. Blood urea nitrogen and serum creatinine levels were significantly elevated on the 5
day and continued to increase throughout the duration of the experiment; there was a gradual decrease in the
creatinine clearance level, starting from the 5th day of treatment, which was related to the duration and dosage used in the GM treated rats. The administration of captopril progressively reduced the functional deteriorations induced by GM. It is concluded that captopril reduces GMinduced renal damage, suggesting protective effect of captopril against GM nephrotoxicity. |
| first_indexed | 2025-11-14T15:36:58Z |
| format | Article |
| id | iium-32886 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:36:58Z |
| publishDate | 2013 |
| publisher | Research and Reviews (Shastri Educational Trust®) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-328862015-12-18T02:37:20Z http://irep.iium.edu.my/32886/ The effects of Angiotensin-Converting-Enzyme Inhibitor (Captopril) on Gentamicin Nephrotoxicity in rats Al-Attiyah, Zainab M Al-Ani, Imad Matloub Dally Abdul-Kareem, Humam N. Matlop, Enas I. QP Physiology R Medicine (General) RM300 Drugs and their action This study was designed to investigate the effects of captopril on gentamicin nephrotoxicity. Six groups of male Wister rats “15 rats each” were used. Group “C”, was given 1ml of normal saline, group “G25” was injected with a single dose of GM (25mg/Kg/day), group “G50” was injected with a single dose of GM (50mg/Kg/day), group “Cp2” was given a single oral dose of captopril (2mg/day), group “Cp2+G25” was injected with a single dose of GM (25mg/Kg/day) and a single oral dose of captopril (2mg/day), group “Cp2+G50” was injected with a single dose of GM (50mg/Kg/day) and a single oral dose of captopril (2mg/day). Treatment continued daily for 15 days; analysis was performed on days 5, 10 and 15. Blood urea nitrogen and serum creatinine levels were significantly elevated on the 5 day and continued to increase throughout the duration of the experiment; there was a gradual decrease in the creatinine clearance level, starting from the 5th day of treatment, which was related to the duration and dosage used in the GM treated rats. The administration of captopril progressively reduced the functional deteriorations induced by GM. It is concluded that captopril reduces GMinduced renal damage, suggesting protective effect of captopril against GM nephrotoxicity. Research and Reviews (Shastri Educational Trust®) 2013-10-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/32886/1/The_Effects_of_Angiotensin-Converting-Enzyme_Inhibito.pdf Al-Attiyah, Zainab M and Al-Ani, Imad Matloub Dally and Abdul-Kareem, Humam N. and Matlop, Enas I. (2013) The effects of Angiotensin-Converting-Enzyme Inhibitor (Captopril) on Gentamicin Nephrotoxicity in rats. Research and Reviews: Journal of Medical and Health Sciences, 2 (4). pp. 80-87. ISSN 2322-0104 (p) 2319-9865 (e) http://www.rroij.com/jmhs/index.php/jmhs/article/view/RRJMHS67 |
| spellingShingle | QP Physiology R Medicine (General) RM300 Drugs and their action Al-Attiyah, Zainab M Al-Ani, Imad Matloub Dally Abdul-Kareem, Humam N. Matlop, Enas I. The effects of Angiotensin-Converting-Enzyme Inhibitor (Captopril) on Gentamicin Nephrotoxicity in rats |
| title | The effects of Angiotensin-Converting-Enzyme Inhibitor (Captopril) on Gentamicin Nephrotoxicity in rats |
| title_full | The effects of Angiotensin-Converting-Enzyme Inhibitor (Captopril) on Gentamicin Nephrotoxicity in rats |
| title_fullStr | The effects of Angiotensin-Converting-Enzyme Inhibitor (Captopril) on Gentamicin Nephrotoxicity in rats |
| title_full_unstemmed | The effects of Angiotensin-Converting-Enzyme Inhibitor (Captopril) on Gentamicin Nephrotoxicity in rats |
| title_short | The effects of Angiotensin-Converting-Enzyme Inhibitor (Captopril) on Gentamicin Nephrotoxicity in rats |
| title_sort | effects of angiotensin-converting-enzyme inhibitor (captopril) on gentamicin nephrotoxicity in rats |
| topic | QP Physiology R Medicine (General) RM300 Drugs and their action |
| url | http://irep.iium.edu.my/32886/ http://irep.iium.edu.my/32886/ http://irep.iium.edu.my/32886/1/The_Effects_of_Angiotensin-Converting-Enzyme_Inhibito.pdf |