Transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has dual functions mediating both apoptosis and survival of cells. This review focusses on the current regulatory factors that control TRAIL transcription. Here, we also highlight the role of distinct transcription factors that co-oper...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Birkhauser Verlag Basel
2013
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/31734/ http://irep.iium.edu.my/31734/1/tumour.pdf |
| _version_ | 1848780445150347264 |
|---|---|
| author | Md. Azahri, Nor Saadah Kavurma, Mary M. |
| author_facet | Md. Azahri, Nor Saadah Kavurma, Mary M. |
| author_sort | Md. Azahri, Nor Saadah |
| building | IIUM Repository |
| collection | Online Access |
| description | Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has dual functions mediating both apoptosis and survival of cells. This review focusses on the current regulatory factors that control TRAIL transcription. Here, we also highlight the role of distinct transcription factors that co-operate and regulate TRAIL in different pathological states. A better understanding of the molecular signalling pathways of TRAIL-induced cell death and survival in disease may lead to more sophisticated technologies for novel therapeutic targets. © 2013 Springer Basel.
|
| first_indexed | 2025-11-14T15:33:47Z |
| format | Article |
| id | iium-31734 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:33:47Z |
| publishDate | 2013 |
| publisher | Birkhauser Verlag Basel |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-317342014-07-14T07:40:17Z http://irep.iium.edu.my/31734/ Transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand Md. Azahri, Nor Saadah Kavurma, Mary M. Q Science (General) Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has dual functions mediating both apoptosis and survival of cells. This review focusses on the current regulatory factors that control TRAIL transcription. Here, we also highlight the role of distinct transcription factors that co-operate and regulate TRAIL in different pathological states. A better understanding of the molecular signalling pathways of TRAIL-induced cell death and survival in disease may lead to more sophisticated technologies for novel therapeutic targets. © 2013 Springer Basel. Birkhauser Verlag Basel 2013 Article PeerReviewed application/pdf en http://irep.iium.edu.my/31734/1/tumour.pdf Md. Azahri, Nor Saadah and Kavurma, Mary M. (2013) Transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand. Cellular and Molecular Life Sciences, 70 (19). pp. 3617-3629. ISSN 1420-682X http://dx.doi.org/10.1007/s00018-013-1264-x doi:10.1007/s00018-013-1264-x |
| spellingShingle | Q Science (General) Md. Azahri, Nor Saadah Kavurma, Mary M. Transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand |
| title | Transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand |
| title_full | Transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand |
| title_fullStr | Transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand |
| title_full_unstemmed | Transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand |
| title_short | Transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand |
| title_sort | transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand |
| topic | Q Science (General) |
| url | http://irep.iium.edu.my/31734/ http://irep.iium.edu.my/31734/ http://irep.iium.edu.my/31734/ http://irep.iium.edu.my/31734/1/tumour.pdf |