Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination

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Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination

Although present in both humans and chimpanzees, recombination hotspots, at which meiotic crossover events cluster, differ markedly in their genomic location between the species. We report that a 13-base pair sequence motif previously associated with the activity of 40% of human hotspots does not fu...

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Bibliographic Details
Main Authors:	Myers, Simon, Bowden, Rory, Tumian, Afidalina, Bontrop, Ronald E, Freeman, Colin, MacFie, Tammie S., McVean, Gil, Donnelly, Peter
Format:	Article
Language:	English
Published:	American Association for the Advancement of Science 2010
Subjects:	Q Science (General)
Online Access:	http://irep.iium.edu.my/31421/ http://irep.iium.edu.my/31421/1/myers2010.pdf

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