A preliminary investigation of chitosan film as dressing for punch biopsy wounds in rats
Purpose. To investigate the wound healing efficacy of two chitosan films, Chit-AA and Chit-LA, in comparison with a commercial preparation, Omiderm® using punch biopsy wounds in rats. Methods. The punch biopsy wounds were created in the abdominal region of male Wistar rats. The films were evaluated...
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| Format: | Article |
| Language: | English |
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Canadian Society for Pharmaceutical Sciences
2003
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| Online Access: | http://irep.iium.edu.my/30841/ http://irep.iium.edu.my/30841/1/A_preliminary_investigation.pdf |
| _version_ | 1848780349929160704 |
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| author | Khan, TanveerAhmad Peh, Khiang K. |
| author_facet | Khan, TanveerAhmad Peh, Khiang K. |
| author_sort | Khan, TanveerAhmad |
| building | IIUM Repository |
| collection | Online Access |
| description | Purpose. To investigate the wound healing efficacy of two chitosan films, Chit-AA and Chit-LA, in comparison with a commercial preparation, Omiderm® using punch biopsy wounds in rats. Methods. The punch biopsy wounds were created in the abdominal region of male Wistar rats. The films were evaluated in terms of transparency, flexibility, adherence property, ease of removal from wounds without damaging underlying tissues and fluid accumulation. In addition, the wounds were examined for dryness, exudation, contraction, period of epithelialization and scar formation. Results. Chit-AA, Chit-LA and Omiderm® films were comparable in terms of transparency, flexibility, adherence property, ease of film removal from wounds without damaging underlying tissues and fluid accumulation. Although there was no statistically significant difference in wound dryness and exudation between the film treated wounds and untreated wounds (Control), a significant difference was obtained in complete wound closure (t100%), period of epithelialization and scar formation. Conclusions. Both Chit-LA and Chit-AA were able to promote wound healing with minimal scar formation. |
| first_indexed | 2025-11-14T15:32:16Z |
| format | Article |
| id | iium-30841 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:32:16Z |
| publishDate | 2003 |
| publisher | Canadian Society for Pharmaceutical Sciences |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-308412013-08-04T10:05:25Z http://irep.iium.edu.my/30841/ A preliminary investigation of chitosan film as dressing for punch biopsy wounds in rats Khan, TanveerAhmad Peh, Khiang K. RS Pharmacy and materia medica Purpose. To investigate the wound healing efficacy of two chitosan films, Chit-AA and Chit-LA, in comparison with a commercial preparation, Omiderm® using punch biopsy wounds in rats. Methods. The punch biopsy wounds were created in the abdominal region of male Wistar rats. The films were evaluated in terms of transparency, flexibility, adherence property, ease of removal from wounds without damaging underlying tissues and fluid accumulation. In addition, the wounds were examined for dryness, exudation, contraction, period of epithelialization and scar formation. Results. Chit-AA, Chit-LA and Omiderm® films were comparable in terms of transparency, flexibility, adherence property, ease of film removal from wounds without damaging underlying tissues and fluid accumulation. Although there was no statistically significant difference in wound dryness and exudation between the film treated wounds and untreated wounds (Control), a significant difference was obtained in complete wound closure (t100%), period of epithelialization and scar formation. Conclusions. Both Chit-LA and Chit-AA were able to promote wound healing with minimal scar formation. Canadian Society for Pharmaceutical Sciences 2003 Article PeerReviewed application/pdf en http://irep.iium.edu.my/30841/1/A_preliminary_investigation.pdf Khan, TanveerAhmad and Peh, Khiang K. (2003) A preliminary investigation of chitosan film as dressing for punch biopsy wounds in rats. Journal of Pharmacy and Pharmaceutical Sciences, 6 (1). pp. 20-26. ISSN 1482-1826 |
| spellingShingle | RS Pharmacy and materia medica Khan, TanveerAhmad Peh, Khiang K. A preliminary investigation of chitosan film as dressing for punch biopsy wounds in rats |
| title | A preliminary investigation of chitosan film as dressing for punch biopsy wounds in rats
|
| title_full | A preliminary investigation of chitosan film as dressing for punch biopsy wounds in rats
|
| title_fullStr | A preliminary investigation of chitosan film as dressing for punch biopsy wounds in rats
|
| title_full_unstemmed | A preliminary investigation of chitosan film as dressing for punch biopsy wounds in rats
|
| title_short | A preliminary investigation of chitosan film as dressing for punch biopsy wounds in rats
|
| title_sort | preliminary investigation of chitosan film as dressing for punch biopsy wounds in rats |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/30841/ http://irep.iium.edu.my/30841/1/A_preliminary_investigation.pdf |