Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate
A new tridentate nitrogen-sulphur Schiff base has been synthesised from the condensation of di-2-pyridylketone and a novel dithiocarbazate, S-2-methylbenzyl-dithiocarbazate (S2MBDTC). The Schiff base was characterized using various physico-chemical and spectroscopic techniques. The X-ray crystallogr...
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| Format: | Article |
| Language: | English |
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SpringerLink
2011
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| Online Access: | http://irep.iium.edu.my/300/ http://irep.iium.edu.my/300/1/jocc_paper.pdf |
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| author | Ravoof, Thahira Begum Crouse, Karen Anne Tahir, Mohamed Ibrahim Mohamed Rosli, Rozita Watkin, David J. How, Fiona Ni Foong |
| author_facet | Ravoof, Thahira Begum Crouse, Karen Anne Tahir, Mohamed Ibrahim Mohamed Rosli, Rozita Watkin, David J. How, Fiona Ni Foong |
| author_sort | Ravoof, Thahira Begum |
| building | IIUM Repository |
| collection | Online Access |
| description | A new tridentate nitrogen-sulphur Schiff base has been synthesised from the condensation of di-2-pyridylketone and a novel dithiocarbazate, S-2-methylbenzyl-dithiocarbazate (S2MBDTC). The Schiff base was characterized using various physico-chemical and spectroscopic techniques. The X-ray crystallographic analysis of the Schiff base is reported. The Schiff base crystallized in a monoclinic system with a space group of P 21/n, with crystal cell parameters a = 10.8128 (2) Å, b = 9.3832 (2) Å, c = 18.0352 (4) Å, β = 97.1311 (9)°. The Schiff base was found to be inactive against selected microbes and two breast cancer cell lines (MCF-7 = Human breast cancer cell line with positive estrogen receptor and MDA-MB-231 = Human breast cancer cell line with negative estrogen receptor). |
| first_indexed | 2025-11-14T14:18:15Z |
| format | Article |
| id | iium-300 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T14:18:15Z |
| publishDate | 2011 |
| publisher | SpringerLink |
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| spelling | iium-3002012-02-29T06:50:34Z http://irep.iium.edu.my/300/ Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate Ravoof, Thahira Begum Crouse, Karen Anne Tahir, Mohamed Ibrahim Mohamed Rosli, Rozita Watkin, David J. How, Fiona Ni Foong QD Chemistry A new tridentate nitrogen-sulphur Schiff base has been synthesised from the condensation of di-2-pyridylketone and a novel dithiocarbazate, S-2-methylbenzyl-dithiocarbazate (S2MBDTC). The Schiff base was characterized using various physico-chemical and spectroscopic techniques. The X-ray crystallographic analysis of the Schiff base is reported. The Schiff base crystallized in a monoclinic system with a space group of P 21/n, with crystal cell parameters a = 10.8128 (2) Å, b = 9.3832 (2) Å, c = 18.0352 (4) Å, β = 97.1311 (9)°. The Schiff base was found to be inactive against selected microbes and two breast cancer cell lines (MCF-7 = Human breast cancer cell line with positive estrogen receptor and MDA-MB-231 = Human breast cancer cell line with negative estrogen receptor). SpringerLink 2011-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/300/1/jocc_paper.pdf Ravoof, Thahira Begum and Crouse, Karen Anne and Tahir, Mohamed Ibrahim Mohamed and Rosli, Rozita and Watkin, David J. and How, Fiona Ni Foong (2011) Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate. Journal of Chemical Crystallography, 41 (4). pp. 491-495. ISSN 1074-1542 10.1007/s10870-010-9907-3 |
| spellingShingle | QD Chemistry Ravoof, Thahira Begum Crouse, Karen Anne Tahir, Mohamed Ibrahim Mohamed Rosli, Rozita Watkin, David J. How, Fiona Ni Foong Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate |
| title | Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate |
| title_full | Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate |
| title_fullStr | Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate |
| title_full_unstemmed | Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate |
| title_short | Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate |
| title_sort | synthesis, characterisation and biological activities of 2-methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/300/ http://irep.iium.edu.my/300/ http://irep.iium.edu.my/300/1/jocc_paper.pdf |