Microwave-assisted synthesis of sec/tert-butyl 2-arylbenzimidazoles and their unexpected antiproliferative activity towards ER negative breast cancer cells

QR Code

Microwave-assisted synthesis of sec/tert-butyl 2-arylbenzimidazoles and their unexpected antiproliferative activity towards ER negative breast cancer cells

A new series of N-sec/tert-butyl 2-arylbenzimidazole derivatives was synthesised in 85–96% yields within 2–3.5 min by condensing ethyl 3-amino-4-butylamino benzoate with various substituted metabisulfite adducts of benzaldehyde under focused microwave irradiation. The benzimidazole analogues were ch...

Full description

Bibliographic Details
Main Authors:	Abdul Rahim, Aisyah Saad, Muhamad Salhimi, Salizawati, Natarajan, Arumugam, Lim, Chung Pin, Ng, Shy Yee, Muttiah, Nithya Niranjini, Wong , Boon Keat, Abd Hamid, Shafida, Osman, Hasnah, Mat, Ishak
Format:	Article
Language:	English
Published:	Informa UK, Ltd. 2013
Subjects:	QD Chemistry RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/29457/ http://irep.iium.edu.my/29457/4/JEnxInhibition.pdf

Similar Items

ethyl 1-sec-butyl-2-(4-fluorophenyl)-1H-benzimidazole-5-carboylate
by: Arumugam, Natarajan, et al.
Published: (2011)

Ethyl 2-(4-bromophenyl)-1-sec-butyl-1H-benzimidazole-5-carboxylate
by: Arumugam, Natarajan, et al.
Published: (2011)

Ethyl 1-sec-butyl-2-phenyl-1H-benzimidazole-5-carboxylate
by: Arumugam, Natarajan, et al.
Published: (2010)

Ethyl 1-tert-butyl-2-(4-methoxyphenyl)-1H-benzimidazole-5-carboxylate
by: Arumugam, Natarajan, et al.
Published: (2010)

Straightforward synthesis of novel 1-(2'-α-O-D-glucopyranosyl ethyl) 2-arylbenzimidazoles
by: Arumugam, Natarajan, et al.
Published: (2012)

Genotoxicity Assessment Of Standardised Root Extract Of Eurycoma Longifolia Jack And Synthesis Of Some Benzimidazole Derivatives And Evaluation Of Their Anti-Cancer Potential
by: Muttiah, Nithya Niranjini
Published: (2013)

Formulation, Characterisation And In Vitro Skin Irritation Studies Of Jasminum Officinale And Anthemis Nobilis Essential Oil Nanoemulsion For Aedes AEGYPTI Repellent Activity
by: Muttiah, Nithya Niranjini
Published: (2019)

Synthesis of highly porous poly(tert-butyl acrylate)-b-polysulfone-b-poly(tert-butyl acrylate) asymmetric membranes
by: Xie, Y., et al.
Published: (2016)

2-sec-Butyl-1-(2-hydroxyethyl)-1H-benzimidazole-5-carboxylic acid
by: Hamzah, Nurasyikin, et al.
Published: (2012)

Simulation Of Reactive Distillation Column Of Methyl Tert- Butyl Ether Production
by: Shanmugasundaram, Parrathen
Published: (2021)

Cancer associated mutations in Sec61γ alter the permeability of the ER translocase
by: Witham, Christopher M., et al.
Published: (2021)

Tailoring the nitrogen sources of bacterial culture to enhance methyl tert-butyl ether degradation
by: Ainon, Hamzah, et al.
Published: (2015)

Modelling And Study Of Control Structures Of Reactive Distillation For The Production Of Methyl Tert-Butyl Ether (MTBE)
by: Jeffrey Lee, Jie Yi
Published: (2021)

Synthesis and X-ray Analysis of (RS)-N-tert-butyl-2-anilino- 3,3-dimethylbutanamide
by: M. M., Yusoff, et al.
Published: (1997)

Neural-Wiener-based Model Predictive Control (NWMPC) for Methyl Tert-butyl Ether Catalytic Distillation
by: Sudibyo, Sudibyo, et al.
Published: (2015)

Steady State Multiplicity In The Reactive Distillation Of Methyl Tert-Butyl Ether (MTBE) Synthesis: Stability Analysis
by: Adnan, Fietriey Atiera Shahida
Published: (2021)

Bis(N-sec-butyl-N-n-propyldithiocarbamato- 2S,S')(1,10-phenanthroline- 2N,N')zinc(II)
by: Alzaalouk, Amna Salem, et al.
Published: (2010)

Modelling Of Reactive Distillation For The Production Of Methyl Tert-Butyl Ether (MTBE) Parametric Sensitivity Study On Kinetic Model
by: Mohamed Zubir, Mohamed Fahim
Published: (2021)

Generation of BroÌˆnsted acidity in AlMCM-41 by sulphation for enhanced liquid phase tert-butylation of phenol
by: Ng, Eng Poh, et al.
Published: (2007)

4-(sec-butylamino)-3-nitrobenzoic acid
by: Narendra Babu, Shivanagere Nagojappa, et al.
Published: (2009)

Isolation and characterisation of 2-Tert-butyl-8-hydroxyquinoline as a crystalline solid and its blue fluorescent Li complex
by: Kathirgamanathan, Poopathy, et al.
Published: (2014)

Expect the unexpected
by: Sutherland, Janet
Published: (2012)

4-tert-Butylamino-3-nitrobenzoic acid
by: Narendra Babu, Shivanagere Nagojappa, et al.
Published: (2009)

Simplified E-Content system (SECS)
by: Oon, Seau Foong
Published: (2014)

Crystal structure of 1,5-di-tert-butyl-2-iminoimidazolidin-4-one, C11H21N3O
by: M. M., Yusoff, et al.
Published: (1998)

Experimental measurement and prediction of thermophysical properties of methyl tert-butyl ether (MTBE) with methanol, diisopropyl ether (DIPE) and N-methylaniline binary mixtures
by: Ali, Mohammed Rashid
Published: (2019)

Dual tongue: the unexpected origin
by: Naserrudin, Nadia Syafeera, et al.
Published: (2018)

Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines
by: Al-Douh, Mohammed Hadi, et al.
Published: (2012)

Biosynthesis and optimization of methyl 3-(3,5- di-tert-butyl-4-hydroxyphenyl) propionate production from oil palm frond juice by ceratocystis fimbriata
by: Nang Nor Azimah, Long Nadzri
Published: (2018)

A surface potential study of ion-uptake by 5,11,17,23-tetra-tert-butyl-25,27-diethoxycarbonyl methyleneoxy-26,28,dihydroxycalix[4]arene and 5,17-(3-nitrobenzylideneamino)-11,23-di-tert-butyl-25,27- diethoxycarbonyl methyleneoxy-26,28-dihydroxycalix[4]arene Langmuir Blodgett (LB) monolayers
by: F.L. Supian,, et al.
Published: (2010)

Exploiting unexpected situations in the mathematics classroom
by: Foster, Colin
Published: (2014)

ESG investment and risks: conceptualise the unexpected
by: Mohamed Yousop, Nur Liyana, et al.
Published: (2023)

Synthesis and Applications of tert-Alkylphosphines
by: Barber, Thomas
Published: (2021)

Crystal structure of 1,5-di-tert-butyl-2-(methylamino)-2-imidazolin-4-one monohydrate, C12H24N3O1.5
by: M. M., Yusoff, et al.
Published: (1998)

Thermophysical and spectroscopic approach on molecular interactions of methyl-tert-butyl ether with ethanol at temperatures of 303.15 K, 308.15 K, 313.15 K, and 318.15 K
by: K., Ramesh, et al.
Published: (2018)

Full Factorial Design for Production of Methyl 3-(3,5-Di-Tert-Butyl-4-Hydroxyphenyl) Propionate Using Oil Palm Frond Juice as a Sole Substrate by Ceratocystis fimbriata
by: Nang Nor Azimah, Long Nadzri, et al.
Published: (2017)

Full Factorial Design for Production of Methyl 3-(3,5-Di-Tert-Butyl-4-Hydroxyphenyl) Propionate Using Oil Palm Frond Juice as a Sole Substrate by Ceratocystis fimbriata
by: Nang Nor Azimah, Long Nadzri, et al.
Published: (2018)

The accidental audience: industrial management of unexpected television viewerships
by: Burdfield, Claire
Published: (2017)

Tribute to Daedalus: Fertile mind that led to unexpected places
by: Poliakoff, Martyn, et al.
Published: (2017)

Investor Sentiment, Unexpected Inflation, and Bitcoin Basis Risk
by: Conlon, T., et al.
Published: (2024)