Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases
products, including proteases. The role of these proteases in the melioidosis, however, remains obscure. Previous findings have hinted at the inherent pathogenicity of the protease during B. pseudomallei K96243 infection. We chose to study the two major families peptidases, i.e. serine peptidases an...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier Ltd.
2012
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| Online Access: | http://irep.iium.edu.my/28704/ http://irep.iium.edu.my/28704/1/1-s2.0-S1877050912005881-main.pdf |
| _version_ | 1848780006375817216 |
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| author | Muhamad Bunnori, Noraslinda Mohamed, Rahmah |
| author_facet | Muhamad Bunnori, Noraslinda Mohamed, Rahmah |
| author_sort | Muhamad Bunnori, Noraslinda |
| building | IIUM Repository |
| collection | Online Access |
| description | products, including proteases. The role of these proteases in the melioidosis, however, remains obscure. Previous findings have hinted at the inherent pathogenicity of the protease during B. pseudomallei K96243 infection. We chose to study the two major families peptidases, i.e. serine peptidases and metallopeptidases present in B. pseudomallei K96243. The data mining revealed eighty ORFs (open reading frame) that potentially code for these peptidases and have prominent homology with B. pseudomallei K96243 based on prediction of function by bioinformatics approach. The annotations and classification lead forty eight and thirty two putative peptidases belong to serine peptidase and metallopeptidase,respectively. The distribution of 98% from the identified putative peptidase belongs to endopeptidases (EC 3.4.21. and EC 3.4.24.) and exopeptidases (EC 3.4.11., EC 3.4.13., EC 3.4.14., EC 3.4.16. and EC 3.4.17) and another 2% belong to EC 3.5. |
| first_indexed | 2025-11-14T15:26:48Z |
| format | Article |
| id | iium-28704 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:26:48Z |
| publishDate | 2012 |
| publisher | Elsevier Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-287042013-02-13T08:33:39Z http://irep.iium.edu.my/28704/ Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases Muhamad Bunnori, Noraslinda Mohamed, Rahmah Q350 Information theory products, including proteases. The role of these proteases in the melioidosis, however, remains obscure. Previous findings have hinted at the inherent pathogenicity of the protease during B. pseudomallei K96243 infection. We chose to study the two major families peptidases, i.e. serine peptidases and metallopeptidases present in B. pseudomallei K96243. The data mining revealed eighty ORFs (open reading frame) that potentially code for these peptidases and have prominent homology with B. pseudomallei K96243 based on prediction of function by bioinformatics approach. The annotations and classification lead forty eight and thirty two putative peptidases belong to serine peptidase and metallopeptidase,respectively. The distribution of 98% from the identified putative peptidase belongs to endopeptidases (EC 3.4.21. and EC 3.4.24.) and exopeptidases (EC 3.4.11., EC 3.4.13., EC 3.4.14., EC 3.4.16. and EC 3.4.17) and another 2% belong to EC 3.5. Elsevier Ltd. 2012 Article PeerReviewed application/pdf en http://irep.iium.edu.my/28704/1/1-s2.0-S1877050912005881-main.pdf Muhamad Bunnori, Noraslinda and Mohamed, Rahmah (2012) Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases. Procedia Computer Science, 11. pp. 36-42. ISSN 1877-0509 http://www.sciencedirect.com/science/article/pii/S1877050912005881 10.1016/j.procs.2012.09.005 |
| spellingShingle | Q350 Information theory Muhamad Bunnori, Noraslinda Mohamed, Rahmah Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases |
| title | Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases |
| title_full | Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases |
| title_fullStr | Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases |
| title_full_unstemmed | Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases |
| title_short | Identification and characterization of Burkholderia pseudomallei K96243 serine and metallopeptidases |
| title_sort | identification and characterization of burkholderia pseudomallei k96243 serine and metallopeptidases |
| topic | Q350 Information theory |
| url | http://irep.iium.edu.my/28704/ http://irep.iium.edu.my/28704/ http://irep.iium.edu.my/28704/ http://irep.iium.edu.my/28704/1/1-s2.0-S1877050912005881-main.pdf |