E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53
E2FBP1/DRIL1 is an AT-rich interaction domain DNAbinding protein and is ubiquitously expressed in various tissues. It has been shown that Bright, the mouse orthologue of E2FBP1/DRIL1, exhibits sequence-specific DNA binding and regulates immunoglobulin transcription. Here we show a novel connection b...
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| Format: | Article |
| Language: | English |
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American Association for Cancer Research
2003
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| Online Access: | http://irep.iium.edu.my/28001/ http://irep.iium.edu.my/28001/1/438.pdf |
| _version_ | 1848779902433624064 |
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| author | Ma, Kaiwen Araki, Keigo Arief Ichwan, Solachuddin Jauhari |
| author_facet | Ma, Kaiwen Araki, Keigo Arief Ichwan, Solachuddin Jauhari |
| author_sort | Ma, Kaiwen |
| building | IIUM Repository |
| collection | Online Access |
| description | E2FBP1/DRIL1 is an AT-rich interaction domain DNAbinding protein and is ubiquitously expressed in various tissues. It has been shown that Bright, the mouse orthologue of E2FBP1/DRIL1, exhibits sequence-specific DNA binding and regulates immunoglobulin transcription. Here we show a novel connection between E2FBP1/ DRIL1 and the p53 tumor suppressor, a key regulator of growth arrest or apoptosis in response to cellular stress. We found a putative p53-binding site, which specifically responded to p53, in the second intron of the E2FBP1/ DRIL1 gene. E2FBP1/DRIL1was induced by p53 and upregulated following DNA damage caused by UV radiation or doxorubicin treatment in a manner dependent on endogenous p53. The ectopic expression of E2FBP1/ DRIL1 induced growth arrest in U2OS cells expressing normal p53, but not Saos-2 cells lacking p53. These results suggest that E2FBP1/DRIL1 may play a role in growth suppression mediated by p53. |
| first_indexed | 2025-11-14T15:25:09Z |
| format | Article |
| id | iium-28001 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:25:09Z |
| publishDate | 2003 |
| publisher | American Association for Cancer Research |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-280012013-02-13T21:19:47Z http://irep.iium.edu.my/28001/ E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53 Ma, Kaiwen Araki, Keigo Arief Ichwan, Solachuddin Jauhari RB Pathology E2FBP1/DRIL1 is an AT-rich interaction domain DNAbinding protein and is ubiquitously expressed in various tissues. It has been shown that Bright, the mouse orthologue of E2FBP1/DRIL1, exhibits sequence-specific DNA binding and regulates immunoglobulin transcription. Here we show a novel connection between E2FBP1/ DRIL1 and the p53 tumor suppressor, a key regulator of growth arrest or apoptosis in response to cellular stress. We found a putative p53-binding site, which specifically responded to p53, in the second intron of the E2FBP1/ DRIL1 gene. E2FBP1/DRIL1was induced by p53 and upregulated following DNA damage caused by UV radiation or doxorubicin treatment in a manner dependent on endogenous p53. The ectopic expression of E2FBP1/ DRIL1 induced growth arrest in U2OS cells expressing normal p53, but not Saos-2 cells lacking p53. These results suggest that E2FBP1/DRIL1 may play a role in growth suppression mediated by p53. American Association for Cancer Research 2003-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/28001/1/438.pdf Ma, Kaiwen and Araki, Keigo and Arief Ichwan, Solachuddin Jauhari (2003) E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53. Molecular Cancer Research, 1 (6). pp. 438-444. ISSN 1541-7786 http://mcr.aacrjournals.org/content/1/6.toc PMID: 12692263 |
| spellingShingle | RB Pathology Ma, Kaiwen Araki, Keigo Arief Ichwan, Solachuddin Jauhari E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53 |
| title | E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53 |
| title_full | E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53 |
| title_fullStr | E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53 |
| title_full_unstemmed | E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53 |
| title_short | E2FBP1/DRIL1, an AT-Rich interaction domain-family transcription factor, is regulated by p53 |
| title_sort | e2fbp1/dril1, an at-rich interaction domain-family transcription factor, is regulated by p53 |
| topic | RB Pathology |
| url | http://irep.iium.edu.my/28001/ http://irep.iium.edu.my/28001/ http://irep.iium.edu.my/28001/ http://irep.iium.edu.my/28001/1/438.pdf |