Pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng
Phytochemical analysis on the crude ethanolic extract of leaves of Malaysian Plectranthus amboinensis (Lour) Spreng was carried out to delineate the presence of its chemical constituents like Alkaloid, Flavonoid, Saponin, Triterpenoid, Steroid, and Phenolic. Acute oral toxicity at one dose level of...
| Main Authors: | , , , |
|---|---|
| Format: | Proceeding Paper |
| Language: | English English |
| Published: |
2012
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/27434/ http://irep.iium.edu.my/27434/1/27434.pdf http://irep.iium.edu.my/27434/3/27434_poster.pdf |
| _version_ | 1848779818884136960 |
|---|---|
| author | Ramli, Norazsida Oothuman, Pakeer Bakhtiar, M. Taher El-Hady Sayed Ahmed, Hassan Mohammed |
| author_facet | Ramli, Norazsida Oothuman, Pakeer Bakhtiar, M. Taher El-Hady Sayed Ahmed, Hassan Mohammed |
| author_sort | Ramli, Norazsida |
| building | IIUM Repository |
| collection | Online Access |
| description | Phytochemical analysis on the crude ethanolic extract of leaves of Malaysian Plectranthus amboinensis (Lour) Spreng was carried out to delineate the presence of its chemical constituents like Alkaloid, Flavonoid, Saponin, Triterpenoid, Steroid, and Phenolic. Acute oral toxicity at one dose level of 5000 mg/kg as per OECD Guideline for Testing of Chemicals 423 was conducted to evaluate the safeness of this extract to be consumed by humans. 20 mice were divided into one control group and one experimental group. All the mice were observed for signs of toxicity, mortality, weight changes and gross pathological changes. Results on phytochemical analysis showed only flavanoid was present in the extract. The acute oral toxicity test revealed that no mortality or evidence of adverse effects were seen in the treated mice. Studies on histopathological examination of kidneys and liver showed normal architecture suggesting no morphological changes. Thus this ethanolic extract of leave P. amboinensis can be considered as safe as it did not cause either any lethality or adverse changes in mice. |
| first_indexed | 2025-11-14T15:23:49Z |
| format | Proceeding Paper |
| id | iium-27434 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T15:23:49Z |
| publishDate | 2012 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-274342017-07-06T01:22:00Z http://irep.iium.edu.my/27434/ Pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng Ramli, Norazsida Oothuman, Pakeer Bakhtiar, M. Taher El-Hady Sayed Ahmed, Hassan Mohammed RS Pharmacy and materia medica Phytochemical analysis on the crude ethanolic extract of leaves of Malaysian Plectranthus amboinensis (Lour) Spreng was carried out to delineate the presence of its chemical constituents like Alkaloid, Flavonoid, Saponin, Triterpenoid, Steroid, and Phenolic. Acute oral toxicity at one dose level of 5000 mg/kg as per OECD Guideline for Testing of Chemicals 423 was conducted to evaluate the safeness of this extract to be consumed by humans. 20 mice were divided into one control group and one experimental group. All the mice were observed for signs of toxicity, mortality, weight changes and gross pathological changes. Results on phytochemical analysis showed only flavanoid was present in the extract. The acute oral toxicity test revealed that no mortality or evidence of adverse effects were seen in the treated mice. Studies on histopathological examination of kidneys and liver showed normal architecture suggesting no morphological changes. Thus this ethanolic extract of leave P. amboinensis can be considered as safe as it did not cause either any lethality or adverse changes in mice. 2012 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/27434/1/27434.pdf application/pdf en http://irep.iium.edu.my/27434/3/27434_poster.pdf Ramli, Norazsida and Oothuman, Pakeer and Bakhtiar, M. Taher and El-Hady Sayed Ahmed, Hassan Mohammed (2012) Pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng. In: 13th Medicinal & Aromatic Seminar 2012, 25th-26th September 2012, Sunway Putra Hotel, Kuala Lumpur. (Unpublished) |
| spellingShingle | RS Pharmacy and materia medica Ramli, Norazsida Oothuman, Pakeer Bakhtiar, M. Taher El-Hady Sayed Ahmed, Hassan Mohammed Pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng |
| title | Pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng |
| title_full | Pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng |
| title_fullStr | Pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng |
| title_full_unstemmed | Pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng |
| title_short | Pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of Plectranthus amboinensis (Lour) Spreng |
| title_sort | pythochemical analysis and acute oral toxicity study of the ethanolic leaves extract of plectranthus amboinensis (lour) spreng |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/27434/ http://irep.iium.edu.my/27434/1/27434.pdf http://irep.iium.edu.my/27434/3/27434_poster.pdf |