The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients
The reduction of capillary luminal area within dermal microcirculation in diabetic foot patients contributes towards the development of foot ulceration and subsequent failure to heal existing ulcers. We studied 42 subjects, involving 10 controls, 16 patients with neuropathic ulcer and 16 patients wi...
| Main Authors: | , , , |
|---|---|
| Format: | Proceeding Paper |
| Language: | English English |
| Published: |
2012
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/27249/ http://irep.iium.edu.my/27249/1/MJM_poster_Hazulin.pdf http://irep.iium.edu.my/27249/4/EMSM2012.pdf |
| _version_ | 1848779789962313728 |
|---|---|
| author | Mohd Radzuan, Hazulin Myint, Yi Yi Tun, Ye Zulkifly, Ahmad Hafiz |
| author_facet | Mohd Radzuan, Hazulin Myint, Yi Yi Tun, Ye Zulkifly, Ahmad Hafiz |
| author_sort | Mohd Radzuan, Hazulin |
| building | IIUM Repository |
| collection | Online Access |
| description | The reduction of capillary luminal area within dermal microcirculation in diabetic foot patients contributes towards the development of foot ulceration and subsequent failure to heal existing ulcers. We studied 42 subjects, involving 10 controls, 16 patients with neuropathic ulcer and 16 patients with neuroischaemic ulcer. The specimens were taken by using skin punch biopsy and were routinely processed for light microscopy. The mean capillary luminal area (LA) and outer area (OA) were performed by calculating and measuring 3 selected capillaries in each slide of every patient and their percentages of ratio were recorded. We noted that there was significant decrement in percentages of LA:OA among the diseased group as compared to the controls, F(2, 39)=17.54, p<0.05. The Tukey post-hoc comparisons showed that the percentages of LA:OA of neuroischemic group (M=31.89, 95% CI [24.79, 39.00]) was significantly reduced as compared to neuropathic group (M=41.76, 95% CI [37.69, 45.82]) since p<0.05. In conclusion, the reduction of dermal capillary luminal area among diabetic foot patients could be due to the alteration in the microvascular hemeorheology, causing basement membrane thickening as the results of the metabolic disease. |
| first_indexed | 2025-11-14T15:23:22Z |
| format | Proceeding Paper |
| id | iium-27249 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T15:23:22Z |
| publishDate | 2012 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-272492020-10-15T07:48:17Z http://irep.iium.edu.my/27249/ The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients Mohd Radzuan, Hazulin Myint, Yi Yi Tun, Ye Zulkifly, Ahmad Hafiz QM Human anatomy The reduction of capillary luminal area within dermal microcirculation in diabetic foot patients contributes towards the development of foot ulceration and subsequent failure to heal existing ulcers. We studied 42 subjects, involving 10 controls, 16 patients with neuropathic ulcer and 16 patients with neuroischaemic ulcer. The specimens were taken by using skin punch biopsy and were routinely processed for light microscopy. The mean capillary luminal area (LA) and outer area (OA) were performed by calculating and measuring 3 selected capillaries in each slide of every patient and their percentages of ratio were recorded. We noted that there was significant decrement in percentages of LA:OA among the diseased group as compared to the controls, F(2, 39)=17.54, p<0.05. The Tukey post-hoc comparisons showed that the percentages of LA:OA of neuroischemic group (M=31.89, 95% CI [24.79, 39.00]) was significantly reduced as compared to neuropathic group (M=41.76, 95% CI [37.69, 45.82]) since p<0.05. In conclusion, the reduction of dermal capillary luminal area among diabetic foot patients could be due to the alteration in the microvascular hemeorheology, causing basement membrane thickening as the results of the metabolic disease. 2012-11-22 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/27249/1/MJM_poster_Hazulin.pdf application/pdf en http://irep.iium.edu.my/27249/4/EMSM2012.pdf Mohd Radzuan, Hazulin and Myint, Yi Yi and Tun, Ye and Zulkifly, Ahmad Hafiz (2012) The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients. In: 21st Scientific Conference Of The Microscopy Society Malaysia, 22-24 Nov 2012, Kota Bharu, Kelantan. |
| spellingShingle | QM Human anatomy Mohd Radzuan, Hazulin Myint, Yi Yi Tun, Ye Zulkifly, Ahmad Hafiz The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients |
| title | The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients |
| title_full | The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients |
| title_fullStr | The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients |
| title_full_unstemmed | The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients |
| title_short | The diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients |
| title_sort | diminution of capillary luminal area within dermal microcirculation and its association in diabetic foot ulcer patients |
| topic | QM Human anatomy |
| url | http://irep.iium.edu.my/27249/ http://irep.iium.edu.my/27249/1/MJM_poster_Hazulin.pdf http://irep.iium.edu.my/27249/4/EMSM2012.pdf |