Microencapsulation of Cassia Alata: fabrication and characterization
Senna alata or Cassia alata (C. alata) is a plant belonging to the family Leguminosae and has been documented to have antifungal and antimicrobial activities. This research aims to extract C. alata, followed by microencapsulation by solvent-evaporation using biodegradable PLGA. The microsphere is en...
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| Format: | Article |
| Language: | English |
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Academic Sciences
2012
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| Online Access: | http://irep.iium.edu.my/26947/ http://irep.iium.edu.my/26947/1/MIcroenapsulation_of_cassia_alata_fabrication_n_characterization.pdf |
| _version_ | 1848779732921876480 |
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| author | Alfatama, Mulham Ahmad, Kausar Mohamed, Farahidah |
| author_facet | Alfatama, Mulham Ahmad, Kausar Mohamed, Farahidah |
| author_sort | Alfatama, Mulham |
| building | IIUM Repository |
| collection | Online Access |
| description | Senna alata or Cassia alata (C. alata) is a plant belonging to the family Leguminosae and has been documented to have antifungal and antimicrobial activities. This research aims to extract C. alata, followed by microencapsulation by solvent-evaporation using biodegradable PLGA. The microsphere is envisaged to release the extract in a controlled manner allowing more convenient mode of administration when treating related skin infection. Several variables had been investigated including different types of surfactants and buffer systems and different homogenization times for primary emulsion. It was found that, most of the surfactants employed resulted in low encapsulation efficiency (<10%). However with 3% poly vinyl
alcohol (PVA), slightly higher encapsulation efficiency of 11% was achieved, with size distribution of 7-13 μm. The encapsulation efficiencies were significantly improved (45-64.4%) when the hardening tank was buffered to pH 7, with minimal effect on particle size. Additionally, in-vitro
controlled release formulation of C. alata microsphere was demonstrated for duration of almost a month. |
| first_indexed | 2025-11-14T15:22:27Z |
| format | Article |
| id | iium-26947 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:22:27Z |
| publishDate | 2012 |
| publisher | Academic Sciences |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-269472014-06-16T02:44:58Z http://irep.iium.edu.my/26947/ Microencapsulation of Cassia Alata: fabrication and characterization Alfatama, Mulham Ahmad, Kausar Mohamed, Farahidah RS Pharmacy and materia medica Senna alata or Cassia alata (C. alata) is a plant belonging to the family Leguminosae and has been documented to have antifungal and antimicrobial activities. This research aims to extract C. alata, followed by microencapsulation by solvent-evaporation using biodegradable PLGA. The microsphere is envisaged to release the extract in a controlled manner allowing more convenient mode of administration when treating related skin infection. Several variables had been investigated including different types of surfactants and buffer systems and different homogenization times for primary emulsion. It was found that, most of the surfactants employed resulted in low encapsulation efficiency (<10%). However with 3% poly vinyl alcohol (PVA), slightly higher encapsulation efficiency of 11% was achieved, with size distribution of 7-13 μm. The encapsulation efficiencies were significantly improved (45-64.4%) when the hardening tank was buffered to pH 7, with minimal effect on particle size. Additionally, in-vitro controlled release formulation of C. alata microsphere was demonstrated for duration of almost a month. Academic Sciences 2012 Article PeerReviewed application/pdf en http://irep.iium.edu.my/26947/1/MIcroenapsulation_of_cassia_alata_fabrication_n_characterization.pdf Alfatama, Mulham and Ahmad, Kausar and Mohamed, Farahidah (2012) Microencapsulation of Cassia Alata: fabrication and characterization. International Journal of Pharmacy and Pharmaceutical Sciences, 4 (4). pp. 219-224. ISSN 0975-1491 http://www.ijppsjournal.com/ |
| spellingShingle | RS Pharmacy and materia medica Alfatama, Mulham Ahmad, Kausar Mohamed, Farahidah Microencapsulation of Cassia Alata: fabrication and characterization |
| title | Microencapsulation of Cassia Alata: fabrication and characterization |
| title_full | Microencapsulation of Cassia Alata: fabrication and characterization |
| title_fullStr | Microencapsulation of Cassia Alata: fabrication and characterization |
| title_full_unstemmed | Microencapsulation of Cassia Alata: fabrication and characterization |
| title_short | Microencapsulation of Cassia Alata: fabrication and characterization |
| title_sort | microencapsulation of cassia alata: fabrication and characterization |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/26947/ http://irep.iium.edu.my/26947/ http://irep.iium.edu.my/26947/1/MIcroenapsulation_of_cassia_alata_fabrication_n_characterization.pdf |