Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia
Protein phosphatase inhibition assay (PPIA), Neuroblastoma cell-based assay (Neuro-2a CBA)and LC-MS/MS analysis revealed for the first time the production of okadaic acid (OA) by a Prorocentrum rhathymum strain. Low amounts of OA were detected by LC-MS/MS analysis.Inhibition of PP2A activity and a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2010
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| Online Access: | http://irep.iium.edu.my/2638/ http://irep.iium.edu.my/2638/1/P-rhathymum_-Toxicon.pdf |
| _version_ | 1848776031317524480 |
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| author | Caillaud, A de la Iglesia, P Campa` s, M Elandaloussi, L Ferna´ndez, M Mohammad Noor, Normawaty Andree, K Dioge`ne, J |
| author_facet | Caillaud, A de la Iglesia, P Campa` s, M Elandaloussi, L Ferna´ndez, M Mohammad Noor, Normawaty Andree, K Dioge`ne, J |
| author_sort | Caillaud, A |
| building | IIUM Repository |
| collection | Online Access |
| description | Protein phosphatase inhibition assay (PPIA), Neuroblastoma cell-based assay (Neuro-2a CBA)and LC-MS/MS analysis revealed for the first time the production of okadaic acid (OA) by
a Prorocentrum rhathymum strain. Low amounts of OA were detected by LC-MS/MS analysis.Inhibition of PP2A activity and a weak toxicity to the Neuro-2a CBA were also observed. |
| first_indexed | 2025-11-14T14:23:37Z |
| format | Article |
| id | iium-2638 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T14:23:37Z |
| publishDate | 2010 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-26382011-12-20T08:44:29Z http://irep.iium.edu.my/2638/ Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia Caillaud, A de la Iglesia, P Campa` s, M Elandaloussi, L Ferna´ndez, M Mohammad Noor, Normawaty Andree, K Dioge`ne, J QD Chemistry SH Aquaculture. Fisheries. Angling Protein phosphatase inhibition assay (PPIA), Neuroblastoma cell-based assay (Neuro-2a CBA)and LC-MS/MS analysis revealed for the first time the production of okadaic acid (OA) by a Prorocentrum rhathymum strain. Low amounts of OA were detected by LC-MS/MS analysis.Inhibition of PP2A activity and a weak toxicity to the Neuro-2a CBA were also observed. Elsevier 2010 Article PeerReviewed application/pdf en http://irep.iium.edu.my/2638/1/P-rhathymum_-Toxicon.pdf Caillaud, A and de la Iglesia, P and Campa` s, M and Elandaloussi, L and Ferna´ndez, M and Mohammad Noor, Normawaty and Andree, K and Dioge`ne, J (2010) Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia. Toxicon, 55. pp. 633-637. ISSN 0041-0101 http://www.elsevier.com/locate/toxicon |
| spellingShingle | QD Chemistry SH Aquaculture. Fisheries. Angling Caillaud, A de la Iglesia, P Campa` s, M Elandaloussi, L Ferna´ndez, M Mohammad Noor, Normawaty Andree, K Dioge`ne, J Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia |
| title | Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia |
| title_full | Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia |
| title_fullStr | Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia |
| title_full_unstemmed | Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia |
| title_short | Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia |
| title_sort | evidence of okadaic acid production in a cultured strain of the marine dinoflagellate prorocentrum rhathymum from malaysia |
| topic | QD Chemistry SH Aquaculture. Fisheries. Angling |
| url | http://irep.iium.edu.my/2638/ http://irep.iium.edu.my/2638/ http://irep.iium.edu.my/2638/1/P-rhathymum_-Toxicon.pdf |