Process modelling and debottlenecking study of a vaccine production
The main objective of this work is to model and optimise a locallydeveloped Infectious Coryza (IC) vaccine production. The simulation work is performed using a commercial batch process simulator SuperPro Designer v5.5. Six debottlenecking schemes were analysed using throughput analysis and cost t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IIUM Press
2012
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/25806/ http://irep.iium.edu.my/25806/1/299-1426-1-PB_IEJ_Vol_13-2012.pdf |
| _version_ | 1848779526959529984 |
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| author | Mohamed Safri, Nurul Huda Mel, Maizirwan Foo, Dominic Chwan Yee K.S. Ng, Denny M.L. Chew, Irene |
| author_facet | Mohamed Safri, Nurul Huda Mel, Maizirwan Foo, Dominic Chwan Yee K.S. Ng, Denny M.L. Chew, Irene |
| author_sort | Mohamed Safri, Nurul Huda |
| building | IIUM Repository |
| collection | Online Access |
| description | The main objective of this work is to model and optimise a locallydeveloped
Infectious Coryza (IC) vaccine production. The simulation work is performed
using a commercial batch process simulator SuperPro Designer v5.5. Six
debottlenecking schemes were analysed using throughput analysis and cost to benefit
ratio (CBR) when the annual production is increased by 100%. Based on the economic
analysis, the selected debottlenecking scheme has annual revenue of USD 240 million,
with a gross margin of 9.13% and a return on investment (ROI) of 46.12%. In addition,
the payback period of the selected scheme is estimated to be within three years. |
| first_indexed | 2025-11-14T15:19:11Z |
| format | Article |
| id | iium-25806 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:19:11Z |
| publishDate | 2012 |
| publisher | IIUM Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-258062012-10-25T01:33:34Z http://irep.iium.edu.my/25806/ Process modelling and debottlenecking study of a vaccine production Mohamed Safri, Nurul Huda Mel, Maizirwan Foo, Dominic Chwan Yee K.S. Ng, Denny M.L. Chew, Irene TP155 Chemical engineering TP248.13 Biotechnology The main objective of this work is to model and optimise a locallydeveloped Infectious Coryza (IC) vaccine production. The simulation work is performed using a commercial batch process simulator SuperPro Designer v5.5. Six debottlenecking schemes were analysed using throughput analysis and cost to benefit ratio (CBR) when the annual production is increased by 100%. Based on the economic analysis, the selected debottlenecking scheme has annual revenue of USD 240 million, with a gross margin of 9.13% and a return on investment (ROI) of 46.12%. In addition, the payback period of the selected scheme is estimated to be within three years. IIUM Press 2012 Article PeerReviewed application/pdf en http://irep.iium.edu.my/25806/1/299-1426-1-PB_IEJ_Vol_13-2012.pdf Mohamed Safri, Nurul Huda and Mel, Maizirwan and Foo, Dominic Chwan Yee and K.S. Ng, Denny and M.L. Chew, Irene (2012) Process modelling and debottlenecking study of a vaccine production. IIUM Engineering Journal, 13 (1). pp. 97-107. ISSN 1511-788X http://iium.edu.my/ejournal/index.php/iiumej/article/viewArticle/299 |
| spellingShingle | TP155 Chemical engineering TP248.13 Biotechnology Mohamed Safri, Nurul Huda Mel, Maizirwan Foo, Dominic Chwan Yee K.S. Ng, Denny M.L. Chew, Irene Process modelling and debottlenecking study of a vaccine production |
| title | Process modelling and debottlenecking study of a vaccine production |
| title_full | Process modelling and debottlenecking study of a vaccine production |
| title_fullStr | Process modelling and debottlenecking study of a vaccine production |
| title_full_unstemmed | Process modelling and debottlenecking study of a vaccine production |
| title_short | Process modelling and debottlenecking study of a vaccine production |
| title_sort | process modelling and debottlenecking study of a vaccine production |
| topic | TP155 Chemical engineering TP248.13 Biotechnology |
| url | http://irep.iium.edu.my/25806/ http://irep.iium.edu.my/25806/ http://irep.iium.edu.my/25806/1/299-1426-1-PB_IEJ_Vol_13-2012.pdf |