Batch process modelling and economic evaluation of glucuronidase enzyme production
β-glucuronidases enzyme is a valued product in the pharmaceutical industry. This work features the modeling and optimization of β-glucuronidases enzyme production from recombinant E. coli using SuperPro Designer v5, a commercial batch process simulator. The study focuses on designing an economical...
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| Format: | Article |
| Language: | English |
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OMICS Group
2012
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| Online Access: | http://irep.iium.edu.my/25805/ http://irep.iium.edu.my/25805/1/J_Bioprocess_and_Biotechniques.pdf |
| _version_ | 1848779526674317312 |
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| author | Kamuri, M Firdaus Foo, Dominic Chwan Yee Mel, Maizirwan |
| author_facet | Kamuri, M Firdaus Foo, Dominic Chwan Yee Mel, Maizirwan |
| author_sort | Kamuri, M Firdaus |
| building | IIUM Repository |
| collection | Online Access |
| description | β-glucuronidases enzyme is a valued product in the pharmaceutical industry. This work features the modeling
and optimization of β-glucuronidases enzyme production from recombinant E. coli using SuperPro Designer v5, a
commercial batch process simulator. The study focuses on designing an economically viable β- glucuronidases enzyme
production process. In the base case process, an annual production of 956 batches (corresponding to 8,523 kg) of
β- glucuronidases enzyme was made. Seven alternatives production schemes were further developed for increased
production using batch debottlenecking strategy. The best alternative scheme was reported to achieve a product yield
of 100% increment, with an annual production of 1912 batches of β- glucuronidases enzyme. Economic analysis
determined that the proposed alternative scheme has an annual revenue of USD 44M, with a 15.24% gross margin
and a 29.44% of return on investment. The payback period of this scheme was estimated to be less than four years. |
| first_indexed | 2025-11-14T15:19:11Z |
| format | Article |
| id | iium-25805 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:19:11Z |
| publishDate | 2012 |
| publisher | OMICS Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-258052012-11-06T02:21:02Z http://irep.iium.edu.my/25805/ Batch process modelling and economic evaluation of glucuronidase enzyme production Kamuri, M Firdaus Foo, Dominic Chwan Yee Mel, Maizirwan TP155 Chemical engineering TP248.13 Biotechnology β-glucuronidases enzyme is a valued product in the pharmaceutical industry. This work features the modeling and optimization of β-glucuronidases enzyme production from recombinant E. coli using SuperPro Designer v5, a commercial batch process simulator. The study focuses on designing an economically viable β- glucuronidases enzyme production process. In the base case process, an annual production of 956 batches (corresponding to 8,523 kg) of β- glucuronidases enzyme was made. Seven alternatives production schemes were further developed for increased production using batch debottlenecking strategy. The best alternative scheme was reported to achieve a product yield of 100% increment, with an annual production of 1912 batches of β- glucuronidases enzyme. Economic analysis determined that the proposed alternative scheme has an annual revenue of USD 44M, with a 15.24% gross margin and a 29.44% of return on investment. The payback period of this scheme was estimated to be less than four years. OMICS Group 2012 Article PeerReviewed application/pdf en http://irep.iium.edu.my/25805/1/J_Bioprocess_and_Biotechniques.pdf Kamuri, M Firdaus and Foo, Dominic Chwan Yee and Mel, Maizirwan (2012) Batch process modelling and economic evaluation of glucuronidase enzyme production. Bioprocessing and Biotechniques (S4). pp. 1-7. ISSN 2155-9821 http://dx.doi.org/10.4172/2155-9821.S4-001 |
| spellingShingle | TP155 Chemical engineering TP248.13 Biotechnology Kamuri, M Firdaus Foo, Dominic Chwan Yee Mel, Maizirwan Batch process modelling and economic evaluation of glucuronidase enzyme production |
| title | Batch process modelling and economic evaluation of glucuronidase enzyme production |
| title_full | Batch process modelling and economic evaluation of glucuronidase enzyme production |
| title_fullStr | Batch process modelling and economic evaluation of glucuronidase enzyme production |
| title_full_unstemmed | Batch process modelling and economic evaluation of glucuronidase enzyme production |
| title_short | Batch process modelling and economic evaluation of glucuronidase enzyme production |
| title_sort | batch process modelling and economic evaluation of glucuronidase enzyme production |
| topic | TP155 Chemical engineering TP248.13 Biotechnology |
| url | http://irep.iium.edu.my/25805/ http://irep.iium.edu.my/25805/ http://irep.iium.edu.my/25805/1/J_Bioprocess_and_Biotechniques.pdf |