Novel formulation of ‘painkiller’ using vegetarian capsule
Solid dosage forms can be generally divided into two broad classes, i.e. tablet and capsule. Although the use of tablet is more complicated in terms of formulation, the simpler capsule has inherent problem of having the origin of animal for its gelatin, major constituent of hard gelatin capsule shel...
| Main Authors: | , , , |
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| Format: | Proceeding Paper |
| Language: | English |
| Published: |
2012
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/25023/ http://irep.iium.edu.my/25023/1/IPC_anas_submitted_version.pdf |
| _version_ | 1848779396383506432 |
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| author | Mohamed, Farahidah Awang, Mohamed Helal Uddin, A.B.M. Hazim, Anas Abdillah |
| author_facet | Mohamed, Farahidah Awang, Mohamed Helal Uddin, A.B.M. Hazim, Anas Abdillah |
| author_sort | Mohamed, Farahidah |
| building | IIUM Repository |
| collection | Online Access |
| description | Solid dosage forms can be generally divided into two broad classes, i.e. tablet and capsule. Although the use of tablet is more complicated in terms of formulation, the simpler capsule has inherent problem of having the origin of animal for its gelatin, major constituent of hard gelatin capsule shell. There are a few notorious shortcomings associated with the employment of bovine hard gelatin capsule. Although the source of bovine can be certified halal, but the way the slaughtering is conducted could be an issue. Moreover, the risk of contracting a group of fatal neurodegenerative diseases known as Transmissible Spongiform Encephalopathies (TSEs), especially bovine spongiform encephalopathy (BSE) is highly exposed to the consumers of this bovine-derived gelatin. Therefore, objective of this study is to formulate a painkiller with suitable excipients and encapsulate the powder mix into hard vegetarian capsule. The painkiller of choice is a Non-steroidal Anti-Inflammatory Drug (NSAID) namely Mefenamic Acid, of which the proprietary name is Ponstan®. Several formulation variables were investigated including powder flow properties for each of the ingredients and the powder mix. The effect of the powder mix towards disintegration time of the capsule was evaluated. The disintegration time were compared to that reference drug, Ponstan® capsule. It was found that, each of the ingredients represent different flow properties that contributed to formulation challenge. However, regardless of different ratios of excipients, the disintegration times of the Mefenamic acid vegetarian capsules (MAvege) were within regulatory requirement. In addition, since all excipients employed were of plant origin, the results suggest that this novel formulation of painkiller could be the first promising alternative painkiller suitable for vegetarian. |
| first_indexed | 2025-11-14T15:17:06Z |
| format | Proceeding Paper |
| id | iium-25023 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:17:06Z |
| publishDate | 2012 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-250232023-10-11T07:15:42Z http://irep.iium.edu.my/25023/ Novel formulation of ‘painkiller’ using vegetarian capsule Mohamed, Farahidah Awang, Mohamed Helal Uddin, A.B.M. Hazim, Anas Abdillah RS Pharmacy and materia medica Solid dosage forms can be generally divided into two broad classes, i.e. tablet and capsule. Although the use of tablet is more complicated in terms of formulation, the simpler capsule has inherent problem of having the origin of animal for its gelatin, major constituent of hard gelatin capsule shell. There are a few notorious shortcomings associated with the employment of bovine hard gelatin capsule. Although the source of bovine can be certified halal, but the way the slaughtering is conducted could be an issue. Moreover, the risk of contracting a group of fatal neurodegenerative diseases known as Transmissible Spongiform Encephalopathies (TSEs), especially bovine spongiform encephalopathy (BSE) is highly exposed to the consumers of this bovine-derived gelatin. Therefore, objective of this study is to formulate a painkiller with suitable excipients and encapsulate the powder mix into hard vegetarian capsule. The painkiller of choice is a Non-steroidal Anti-Inflammatory Drug (NSAID) namely Mefenamic Acid, of which the proprietary name is Ponstan®. Several formulation variables were investigated including powder flow properties for each of the ingredients and the powder mix. The effect of the powder mix towards disintegration time of the capsule was evaluated. The disintegration time were compared to that reference drug, Ponstan® capsule. It was found that, each of the ingredients represent different flow properties that contributed to formulation challenge. However, regardless of different ratios of excipients, the disintegration times of the Mefenamic acid vegetarian capsules (MAvege) were within regulatory requirement. In addition, since all excipients employed were of plant origin, the results suggest that this novel formulation of painkiller could be the first promising alternative painkiller suitable for vegetarian. 2012-02 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/25023/1/IPC_anas_submitted_version.pdf Mohamed, Farahidah and Awang, Mohamed and Helal Uddin, A.B.M. and Hazim, Anas Abdillah (2012) Novel formulation of ‘painkiller’ using vegetarian capsule. In: IIUM’s 1st International Postgraduate Research Conference, IIPRC 2012, 20-22 Feb 2012, CAC, IIUM Gombak. |
| spellingShingle | RS Pharmacy and materia medica Mohamed, Farahidah Awang, Mohamed Helal Uddin, A.B.M. Hazim, Anas Abdillah Novel formulation of ‘painkiller’ using vegetarian capsule |
| title | Novel formulation of ‘painkiller’ using vegetarian capsule |
| title_full | Novel formulation of ‘painkiller’ using vegetarian capsule |
| title_fullStr | Novel formulation of ‘painkiller’ using vegetarian capsule |
| title_full_unstemmed | Novel formulation of ‘painkiller’ using vegetarian capsule |
| title_short | Novel formulation of ‘painkiller’ using vegetarian capsule |
| title_sort | novel formulation of ‘painkiller’ using vegetarian capsule |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/25023/ http://irep.iium.edu.my/25023/1/IPC_anas_submitted_version.pdf |