Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice
Light microscopic (LM) and transmission electron microscopic (TEM) observations were performed in the kidneys of oral contraceptive treated mice. Experimental groups were given 0.1 ml of olive oil containing 0.015 fraction of (Neogynon) tablet daily. Control groups were give olive oil alone.Five ex...
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| Format: | Proceeding Paper |
| Language: | English English |
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2008
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| Online Access: | http://irep.iium.edu.my/24876/ http://irep.iium.edu.my/24876/19/Contraception_Power_Point.pps http://irep.iium.edu.my/24876/20/Binder1.pdf |
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| author | Al-Ani, Imad Matloub Dally Noor Al-Deen, Jinan A. Kashmola, Muhanad Ali Hamdon |
| author_facet | Al-Ani, Imad Matloub Dally Noor Al-Deen, Jinan A. Kashmola, Muhanad Ali Hamdon |
| author_sort | Al-Ani, Imad Matloub Dally |
| building | IIUM Repository |
| collection | Online Access |
| description | Light microscopic (LM) and transmission electron microscopic (TEM) observations were performed in the kidneys of oral contraceptive treated mice. Experimental groups were given 0.1 ml of olive oil containing 0.015 fraction of (Neogynon) tablet daily. Control groups were
give olive oil alone.Five experimental and three control animals were scarified after 1,3,6,9,and 12 estrus cycles. Glomerulosclerosis,hyaline arteriopathy associated with focal areas of interstitial fibrosis were observed in the first cycle. Mild hypertrophy of juxtaglomerular apparatus
“JGA” appeared in the 3rd cycle with increased granularity of the JGCs. Proliferative-sclerosing stages of focal glomerulonephritis were observed and were more advanced in cycle twelve.By transmission electron microscope, there were slight changes in the glomeruli during cycle one.
These evident gradually developed in cycle three, thus the glomeruli showed disordered capillary loop occlusion. In cycle six, capillary lumens were occluded by protuberance projection. There were hyperactivity and proliferation of mesangial cells and electron-dense material deposits in
glomerular basal lamina; these deposits were accompanied with electron-lucent materials appeared in cycle 9 behind swelled mesangial cells indicating hyperactivity and proliferative cells which showed abundant RER and mitochondria. These lesions were correlated with hyper-granularityof JGCs and hypertrophied JGA. The JGGs appeared in cycle 12 as heterogenized size. These changes indicate that abuse of oral contraceptives is relatively unsafe, especially after long-term of high-do |
| first_indexed | 2025-11-14T15:16:41Z |
| format | Proceeding Paper |
| id | iium-24876 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T15:16:41Z |
| publishDate | 2008 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-248762015-12-18T02:50:33Z http://irep.iium.edu.my/24876/ Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice Al-Ani, Imad Matloub Dally Noor Al-Deen, Jinan A. Kashmola, Muhanad Ali Hamdon RG Gynecology and obstetrics RM300 Drugs and their action Light microscopic (LM) and transmission electron microscopic (TEM) observations were performed in the kidneys of oral contraceptive treated mice. Experimental groups were given 0.1 ml of olive oil containing 0.015 fraction of (Neogynon) tablet daily. Control groups were give olive oil alone.Five experimental and three control animals were scarified after 1,3,6,9,and 12 estrus cycles. Glomerulosclerosis,hyaline arteriopathy associated with focal areas of interstitial fibrosis were observed in the first cycle. Mild hypertrophy of juxtaglomerular apparatus “JGA” appeared in the 3rd cycle with increased granularity of the JGCs. Proliferative-sclerosing stages of focal glomerulonephritis were observed and were more advanced in cycle twelve.By transmission electron microscope, there were slight changes in the glomeruli during cycle one. These evident gradually developed in cycle three, thus the glomeruli showed disordered capillary loop occlusion. In cycle six, capillary lumens were occluded by protuberance projection. There were hyperactivity and proliferation of mesangial cells and electron-dense material deposits in glomerular basal lamina; these deposits were accompanied with electron-lucent materials appeared in cycle 9 behind swelled mesangial cells indicating hyperactivity and proliferative cells which showed abundant RER and mitochondria. These lesions were correlated with hyper-granularityof JGCs and hypertrophied JGA. The JGGs appeared in cycle 12 as heterogenized size. These changes indicate that abuse of oral contraceptives is relatively unsafe, especially after long-term of high-do 2008-04 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/24876/19/Contraception_Power_Point.pps application/pdf en http://irep.iium.edu.my/24876/20/Binder1.pdf Al-Ani, Imad Matloub Dally and Noor Al-Deen, Jinan A. and Kashmola, Muhanad Ali Hamdon (2008) Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice. In: 17th EMSM Scientific Conference and 18th Annual General Meeting, 18-20 Dec. 2008, Holiday Inn Glenmarie, Shah Alam, Kuala Lumpur. |
| spellingShingle | RG Gynecology and obstetrics RM300 Drugs and their action Al-Ani, Imad Matloub Dally Noor Al-Deen, Jinan A. Kashmola, Muhanad Ali Hamdon Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice |
| title | Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice |
| title_full | Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice |
| title_fullStr | Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice |
| title_full_unstemmed | Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice |
| title_short | Light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice |
| title_sort | light and transmission electron microscopic study on the effect of contraceptive pills on the glomerulus and juxtaglomerular apparatus in mice |
| topic | RG Gynecology and obstetrics RM300 Drugs and their action |
| url | http://irep.iium.edu.my/24876/ http://irep.iium.edu.my/24876/19/Contraception_Power_Point.pps http://irep.iium.edu.my/24876/20/Binder1.pdf |