Histopathological evaluation of skin wound healing in rabbits treated by systemic dexamethasone
The present study was designed to evalurate the effect of dexamethasone on skin wound healing. Fifteen albino rabbits of 6.5 months age were used; an incision and suture was performed on the back skin of ten experimental rabbits previously treated with daily intramuscular injection of 2ml ampoule...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Department of Anatomy, National University of Singapore
2012
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| Online Access: | http://irep.iium.edu.my/24867/ http://irep.iium.edu.my/24867/1/Skin_Wound_Healing.pdf |
| _version_ | 1848779368238678016 |
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| author | Kashmola, Muhanad Ali Hamdon Al-Ani, Imad Matloub Dally Mustafa, Nazih Shaban Mustafa Al-Ahmad, Basma Ezzat |
| author_facet | Kashmola, Muhanad Ali Hamdon Al-Ani, Imad Matloub Dally Mustafa, Nazih Shaban Mustafa Al-Ahmad, Basma Ezzat |
| author_sort | Kashmola, Muhanad Ali Hamdon |
| building | IIUM Repository |
| collection | Online Access |
| description | The present study was designed to evalurate the effect of dexamethasone on skin wound healing. Fifteen albino
rabbits of 6.5 months age were used; an incision and suture was performed on the back skin of ten experimental
rabbits previously treated with daily intramuscular injection of 2ml ampoule containing 4 mg dexamethasone
for one month and on fi ve control rabbits received 2ml normal saline for the same period. Biopsies of operated
skin after 10 days of incision were processed for histopathological evaluation. Histological examination
showed delay healing in experimental group in comparison to control group.
It is concluded that prolonged use of dexamethasone or misuse of this drug suppress wound healing. |
| first_indexed | 2025-11-14T15:16:40Z |
| format | Article |
| id | iium-24867 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:16:40Z |
| publishDate | 2012 |
| publisher | Department of Anatomy, National University of Singapore |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-248672015-12-18T02:43:08Z http://irep.iium.edu.my/24867/ Histopathological evaluation of skin wound healing in rabbits treated by systemic dexamethasone Kashmola, Muhanad Ali Hamdon Al-Ani, Imad Matloub Dally Mustafa, Nazih Shaban Mustafa Al-Ahmad, Basma Ezzat QM Human anatomy QP Physiology RL Dermatology RM300 Drugs and their action The present study was designed to evalurate the effect of dexamethasone on skin wound healing. Fifteen albino rabbits of 6.5 months age were used; an incision and suture was performed on the back skin of ten experimental rabbits previously treated with daily intramuscular injection of 2ml ampoule containing 4 mg dexamethasone for one month and on fi ve control rabbits received 2ml normal saline for the same period. Biopsies of operated skin after 10 days of incision were processed for histopathological evaluation. Histological examination showed delay healing in experimental group in comparison to control group. It is concluded that prolonged use of dexamethasone or misuse of this drug suppress wound healing. Department of Anatomy, National University of Singapore 2012-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/24867/1/Skin_Wound_Healing.pdf Kashmola, Muhanad Ali Hamdon and Al-Ani, Imad Matloub Dally and Mustafa, Nazih Shaban and Mustafa Al-Ahmad, Basma Ezzat (2012) Histopathological evaluation of skin wound healing in rabbits treated by systemic dexamethasone. Annals of Microscopy, 12. pp. 27-33. ISSN 0219-2209 http://www.microscopy.org.sg/journal/vol_12/Annals%20of%20Microscopy%20Vol%2012-Web.pdf |
| spellingShingle | QM Human anatomy QP Physiology RL Dermatology RM300 Drugs and their action Kashmola, Muhanad Ali Hamdon Al-Ani, Imad Matloub Dally Mustafa, Nazih Shaban Mustafa Al-Ahmad, Basma Ezzat Histopathological evaluation of skin wound healing in rabbits treated by systemic dexamethasone |
| title | Histopathological evaluation of skin wound healing in rabbits treated by systemic dexamethasone |
| title_full | Histopathological evaluation of skin wound healing in rabbits treated by systemic dexamethasone |
| title_fullStr | Histopathological evaluation of skin wound healing in rabbits treated by systemic dexamethasone |
| title_full_unstemmed | Histopathological evaluation of skin wound healing in rabbits treated by systemic dexamethasone |
| title_short | Histopathological evaluation of skin wound healing in rabbits treated by systemic dexamethasone |
| title_sort | histopathological evaluation of skin wound healing in rabbits treated by systemic dexamethasone |
| topic | QM Human anatomy QP Physiology RL Dermatology RM300 Drugs and their action |
| url | http://irep.iium.edu.my/24867/ http://irep.iium.edu.my/24867/ http://irep.iium.edu.my/24867/1/Skin_Wound_Healing.pdf |