Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient
Langerhans cell histiocytosis of the spine frequently presents as a solitary lesion and rarely results in neurological deficit. Involvement of thyroid tissue is also rare, even in multifocal disease presentations. We present an unusual variant of Langerhans cell histiocytosis in a 37-year-old man pr...
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| Format: | Article |
| Language: | English |
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Malaysian Orthopaedic Association (MOA)
2011
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| Online Access: | http://irep.iium.edu.my/24412/ http://irep.iium.edu.my/24412/1/Langerhans_Cell_Histiocytosis.pdf |
| _version_ | 1848779293153296384 |
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| author | Sharifudin, Mohd Ariff Johari, Joehaimey Omar, Ahmad Sabri Wan, Zulmi |
| author_facet | Sharifudin, Mohd Ariff Johari, Joehaimey Omar, Ahmad Sabri Wan, Zulmi |
| author_sort | Sharifudin, Mohd Ariff |
| building | IIUM Repository |
| collection | Online Access |
| description | Langerhans cell histiocytosis of the spine frequently presents as a solitary lesion and rarely results in neurological deficit. Involvement of thyroid tissue is also rare, even in multifocal disease presentations. We present an unusual variant of Langerhans cell histiocytosis in a 37-year-old man presenting with profound quadriparesis and incidental thyroid involvement. MR imaging and skeletal radiographs revealed widespread involvement of the spine. The patient underwent surgical resection of the tumour and stabilization of the spine. Diagnosis was confirmed by histological and immunohistochemistry analysis. Langerhans cell histiocytosis should be included in the differential diagnosis of radiolucent lesions of the spine in adults. |
| first_indexed | 2025-11-14T15:15:28Z |
| format | Article |
| id | iium-24412 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:15:28Z |
| publishDate | 2011 |
| publisher | Malaysian Orthopaedic Association (MOA) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-244122013-01-15T14:44:32Z http://irep.iium.edu.my/24412/ Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient Sharifudin, Mohd Ariff Johari, Joehaimey Omar, Ahmad Sabri Wan, Zulmi RD701 Orthopedics Langerhans cell histiocytosis of the spine frequently presents as a solitary lesion and rarely results in neurological deficit. Involvement of thyroid tissue is also rare, even in multifocal disease presentations. We present an unusual variant of Langerhans cell histiocytosis in a 37-year-old man presenting with profound quadriparesis and incidental thyroid involvement. MR imaging and skeletal radiographs revealed widespread involvement of the spine. The patient underwent surgical resection of the tumour and stabilization of the spine. Diagnosis was confirmed by histological and immunohistochemistry analysis. Langerhans cell histiocytosis should be included in the differential diagnosis of radiolucent lesions of the spine in adults. Malaysian Orthopaedic Association (MOA) 2011-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/24412/1/Langerhans_Cell_Histiocytosis.pdf Sharifudin, Mohd Ariff and Johari, Joehaimey and Omar, Ahmad Sabri and Wan, Zulmi (2011) Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient. Malaysian Orthopaedic Journal, 5 (3). pp. 28-31. ISSN 1985-2533 http://www.morthoj.org/2011v5n3/Langerhans_Cell_Histiocytosis.pdf 10.5704/MOJ/1111.004 |
| spellingShingle | RD701 Orthopedics Sharifudin, Mohd Ariff Johari, Joehaimey Omar, Ahmad Sabri Wan, Zulmi Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient |
| title | Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient |
| title_full | Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient |
| title_fullStr | Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient |
| title_full_unstemmed | Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient |
| title_short | Langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient |
| title_sort | langerhans cell histiocytosis with extensive spinal and thyroid gland involvement presenting with quadriparesis: an unusual case in an adult patient |
| topic | RD701 Orthopedics |
| url | http://irep.iium.edu.my/24412/ http://irep.iium.edu.my/24412/ http://irep.iium.edu.my/24412/ http://irep.iium.edu.my/24412/1/Langerhans_Cell_Histiocytosis.pdf |