COX-2 inhibitors: a potential target for drug therapy in the management of colorectal cancer

QR Code

COX-2 inhibitors: a potential target for drug therapy in the management of colorectal cancer

Colorectal cancer is currently the third most common cancer in Malaysia. Elevated expression of COX-2, an induced cyclooxygenase isoenzyme, has been seen in colonic adenomas and colorectal carcinoma. There is evidence that inhibition of this COX-2 can decrease the risk of colorectal cancer. Selectiv...

Full description

Bibliographic Details
Main Authors:	Ryan, A R, Rosita, A R, Khalid, Kamarul Ariffin, Qureshi, Akhtar
Format:	Article
Language:	English
Published:	Malaysian Medical Association 1999
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/23984/ http://irep.iium.edu.my/23984/1/COX-2_Inhibitors_-_A_Potential_Target_for_Drug_Therapy_in_the_Management_of_Colorectal_Cancer.pdf

Similar Items

Identification of drug(s) selectively targeting colorectal cancer stem-like cells for differentiation (differentiation therapy)
by: Ahmed, Mehreen
Published: (2020)

Advances in targeted and immunobased therapies for colorectal cancer in the genomic era
by: Heng, Fong Seow, et al.
Published: (2016)

Drug design and synthesis of cox-2 selective inhibitors as potential NSAIDs / Abeer Abdulhadi Abdulqader
by: Abeer Abdulhadi , Abdulqader
Published: (2016)

Colorectal cancer stem cells: a review of targeted drug delivery by gold nanoparticles
by: Mohd Zahid, Manali Haniti, et al.
Published: (2020)

New Generation Multi-Targets PDE, Cox and Lox (MTPCL) Inhibitors as Leads for the Treatment of Inflammatory Disorders
by: UiTM, Deputy Vice-Chancellor (Research & Innovation)
Published: (2021)

Adaptive therapy to circumvent drug resistance to tyrosine kinase inhibitors in cancer: is it clinically relevant?
by: Hamdi, Amir Imran Faisal, et al.
Published: (2022)

Netrin-1 as a potential target for metastatic cancer: focus on colorectal cancer
by: Ko, S., et al.
Published: (2014)

Colorectal cancer surveillance in Hodgkin lymphoma survivors at increased risk of therapy-related colorectal cancer: Study design
by: Rigter, L., et al.
Published: (2017)

Cancer stem cell metabolism: A potential target for cancer therapy
by: Deshmukh, A., et al.
Published: (2016)

Do STAT3 inhibitors have potential in the future for cancer therapy?
by: Wong, A., et al.
Published: (2017)

Carbon nanomaterials as drug transporter for cancer therapy
by: Che Abdullah, Che Azurahanim, et al.
Published: (2014)

Potential role of targeted therapies in the treatment of triple-negative breast cancer
by: Jia, L., et al.
Published: (2016)

Assessment of ibuprofen, non-selective cox inhibitor, as a neuroprotective agent in Alzheimer’s model of rats
by: Saxena, Anil Kumar, et al.
Published: (2013)

Antibody drug conjugate in cancer therapy
by: Bakhtiar, M. Taher
Published: (2019)

Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors
by: Siveen, K., et al.
Published: (2013)

Molecular targets of colorectal cancer: an insight on intracellular cellular signaling pathways
by: Pandurangan, Ashok Kumar, et al.
Published: (2014)

Dietary non-nutritive factors on molecular targets of colorectal cancer: an update
by: Pandurangan, Ashok Kumar, et al.
Published: (2013)

Preventive inositol hexaphosphate extracted from rice bran inhibits colorectal cancer through involvement of Wnt/β-catenin and COX-2 pathways
by: Shafie, Nurul Husna, et al.
Published: (2013)

Cancer-associated membrane protein as targeted therapy for bladder cancer
by: Roslan, Adlina, et al.
Published: (2022)

Targeting transcription factor STAT3 for cancer prevention and therapy.
by: Chai, E., et al.
Published: (2015)

Assessment of celecoxib, a selective cox-2 inhibitor, as a neuroprotective agent in alzheimer’s model of rats
by: Saxena, Anil Kumar, et al.
Published: (2013)

Subcellular phenomena in colorectal cancer
by: Mirams, Gary R.
Published: (2008)

Biodegradable drug delivery systems for cancer therapy
by: Wong, T., et al.
Published: (2017)

Potential of dihydropyrimidine dehydrogenase genotypes in personalising 5-fluorouracil therapy among colorectal cancer patients
by: Ngow, Harris Abdullah, et al.
Published: (2011)

Potential of dihydropyrimidine dehydrogenase genotypes in personalizing 5-fluorouracil therapy among colorectal cancer patients
by: Teh, Lay Kek, et al.
Published: (2013)

DNA repair in cancer: emerging targets for personalized therapy
by: Abbotts, Rachel, et al.
Published: (2014)

Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy
by: Min-Wen, J., et al.
Published: (2017)

Towards targeted cancer therapy: Aptamer or oncolytic virus?
by: Tan, K., et al.
Published: (2017)

Pancreatic cancer treatment with targeted therapies: are we there yet
by: Nwaefulu, O. Ngozi, et al.
Published: (2022)

Mechanism Of Action Of A Benzimidazole Sirtuin Inhibitor, Bzd9l1, In Colorectal Cancer
by: Tan, Yi Jer
Published: (2022)

Studies of the benzopyran class of selective COX-2 inhibitors using 3D-QSAR and molecular docking
by: Yadav, D., et al.
Published: (2017)

Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: Evidence from an animal model and a human cohort
by: Robinson, C., et al.
Published: (2014)

A Novel Inhibitor Of Sirtuin: Elucidation Of Mode Of Action And Molecular Pathway In Colorectal Cancer Cell Line
by: Tan, Yi Jer
Published: (2017)

Combinatorial application of tocotrienols and chemotherapeutic drugs enhances apoptosis and autophagy in colorectal cancer cells
by: Tham, Shiau Ying
Published: (2020)

Targets and mechanisms of berberine,a natural drug with potential to treat cancer with special focus on breast cancer
by: Kaboli, Parham Jabbarzadeh, et al.
Published: (2014)

Association of Helicobacter pylori with colorectal cancer development.
by: Fouad Alsamaka, Fadi, et al.
Published: (2010)

Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer
by: Shanmugam, M., et al.
Published: (2012)

Targeted therapy for cancer using pH-responsive nanocarrier systems
by: Manchun, S., et al.
Published: (2012)

Aalen’s additive, Cox proportional hazards and the Cox-Aalen model: application to kidney transplant data
by: Başar, Emel
Published: (2017)

Cost-effectiveness of colorectal cancer screening
by: Lansdorp_Vogelaar, Iris, et al.
Published: (2011)