Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides
The glycosynthase derived from E. coli β-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of β-glucuronides under mild conditions...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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American Chemical Society
2008
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| Online Access: | http://irep.iium.edu.my/23428/ http://irep.iium.edu.my/23428/1/Organic_letters_2008.pdf |
| _version_ | 1848779155871629312 |
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| author | Wilkinson, Shane M. Liew, Chu W. Mackay, Joel P. Mohd. Salleh, Hamzah Withers, Stephen G. McLeod, Malcolm D. |
| author_facet | Wilkinson, Shane M. Liew, Chu W. Mackay, Joel P. Mohd. Salleh, Hamzah Withers, Stephen G. McLeod, Malcolm D. |
| author_sort | Wilkinson, Shane M. |
| building | IIUM Repository |
| collection | Online Access |
| description | The glycosynthase derived from E. coli β-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of β-glucuronides under mild conditions. |
| first_indexed | 2025-11-14T15:13:17Z |
| format | Article |
| id | iium-23428 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:13:17Z |
| publishDate | 2008 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-234282021-07-01T10:19:41Z http://irep.iium.edu.my/23428/ Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides Wilkinson, Shane M. Liew, Chu W. Mackay, Joel P. Mohd. Salleh, Hamzah Withers, Stephen G. McLeod, Malcolm D. T175 Industrial research. Research and development TA164 Bioengineering TP248.13 Biotechnology The glycosynthase derived from E. coli β-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of β-glucuronides under mild conditions. American Chemical Society 2008 Article PeerReviewed application/pdf en http://irep.iium.edu.my/23428/1/Organic_letters_2008.pdf Wilkinson, Shane M. and Liew, Chu W. and Mackay, Joel P. and Mohd. Salleh, Hamzah and Withers, Stephen G. and McLeod, Malcolm D. (2008) Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides. Organic Letters, 10 (8). pp. 1585-1588. ISSN 1523-7060 http://pubs.acs.org/doi/abs/10.1021/ol8002767?journalCode=orlef7 10.1021/ol8002767 |
| spellingShingle | T175 Industrial research. Research and development TA164 Bioengineering TP248.13 Biotechnology Wilkinson, Shane M. Liew, Chu W. Mackay, Joel P. Mohd. Salleh, Hamzah Withers, Stephen G. McLeod, Malcolm D. Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides |
| title | Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides |
| title_full | Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides |
| title_fullStr | Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides |
| title_full_unstemmed | Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides |
| title_short | Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides |
| title_sort | escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of β-glucuronides |
| topic | T175 Industrial research. Research and development TA164 Bioengineering TP248.13 Biotechnology |
| url | http://irep.iium.edu.my/23428/ http://irep.iium.edu.my/23428/ http://irep.iium.edu.my/23428/ http://irep.iium.edu.my/23428/1/Organic_letters_2008.pdf |