Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines
This study was designed to determine antiproliferative properties of curcusone B from the stem bark of Jatropha curcas on cell lines K562 (chronic myelogeneous leukemia), and H1299 (human non-small cell lung carcinoma). Cells were cultured in the presence of curcusone B at various concentrations...
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| Format: | Article |
| Language: | English |
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INSI Publications
2011
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| Online Access: | http://irep.iium.edu.my/20337/ http://irep.iium.edu.my/20337/1/antiproliferative_activity_of_curcusone_B_from_jatropha.pdf |
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| author | Sahidin, Nakazibwe, Sauba Taher, Muhammad Kumar Saxena, Anil Arief Ichwan, Solachuddin Jauhari Ardiyansyah, |
| author_facet | Sahidin, Nakazibwe, Sauba Taher, Muhammad Kumar Saxena, Anil Arief Ichwan, Solachuddin Jauhari Ardiyansyah, |
| author_sort | Sahidin, |
| building | IIUM Repository |
| collection | Online Access |
| description | This study was designed to determine antiproliferative properties of curcusone B from the
stem bark of Jatropha curcas on cell lines K562 (chronic myelogeneous leukemia), and H1299
(human non-small cell lung carcinoma). Cells were cultured in the presence of curcusone B at various
concentrations and the percentage of cell viability was evaluated by trypan blue exclusion method and
MTT assay. Curcusone B showed significant dose-dependent inhibition of cell proliferation of K562
and H1299 cell lines with an IC50 of 6 μg/mL and 15.0 μg/mL, respectively. The findings suggested
that the curcusone B had strong antiproliferation which was dose dependent and may have potential
as an anticancer agent. |
| first_indexed | 2025-11-14T15:03:47Z |
| format | Article |
| id | iium-20337 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T15:03:47Z |
| publishDate | 2011 |
| publisher | INSI Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-203372014-03-11T00:29:38Z http://irep.iium.edu.my/20337/ Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines Sahidin, Nakazibwe, Sauba Taher, Muhammad Kumar Saxena, Anil Arief Ichwan, Solachuddin Jauhari Ardiyansyah, RM Therapeutics. Pharmacology This study was designed to determine antiproliferative properties of curcusone B from the stem bark of Jatropha curcas on cell lines K562 (chronic myelogeneous leukemia), and H1299 (human non-small cell lung carcinoma). Cells were cultured in the presence of curcusone B at various concentrations and the percentage of cell viability was evaluated by trypan blue exclusion method and MTT assay. Curcusone B showed significant dose-dependent inhibition of cell proliferation of K562 and H1299 cell lines with an IC50 of 6 μg/mL and 15.0 μg/mL, respectively. The findings suggested that the curcusone B had strong antiproliferation which was dose dependent and may have potential as an anticancer agent. INSI Publications 2011 Article PeerReviewed application/pdf en http://irep.iium.edu.my/20337/1/antiproliferative_activity_of_curcusone_B_from_jatropha.pdf Sahidin, and Nakazibwe, Sauba and Taher, Muhammad and Kumar Saxena, Anil and Arief Ichwan, Solachuddin Jauhari and Ardiyansyah, (2011) Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines. Australian Journal of Basic and Applied Sciences, 5 (8). pp. 47-51. ISSN 1991-8178 |
| spellingShingle | RM Therapeutics. Pharmacology Sahidin, Nakazibwe, Sauba Taher, Muhammad Kumar Saxena, Anil Arief Ichwan, Solachuddin Jauhari Ardiyansyah, Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines |
| title | Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines |
| title_full | Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines |
| title_fullStr | Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines |
| title_full_unstemmed | Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines |
| title_short | Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines |
| title_sort | antiproliferative activity of curcusone b from jatropha curcas on human cancer cell lines |
| topic | RM Therapeutics. Pharmacology |
| url | http://irep.iium.edu.my/20337/ http://irep.iium.edu.my/20337/1/antiproliferative_activity_of_curcusone_B_from_jatropha.pdf |