Parkinsonism complicating acute organophosphate insecticide poisoning
Organophosphate insecticides have a triphasic effect on the central nervous system, namely acute cholinergic crisis, intermediate syndrome and delayed polyneuropathy. Although acute organophosphate poisoning is relatively common, case reports describing parkinsonism as a neurological comp...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Academy of Medicine, Singapore
2011
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/18676/ http://irep.iium.edu.my/18676/1/V40N3p150.pdf |
| _version_ | 1848778234648330240 |
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| author | Hashim, Hasnur Zaman Wan Musa, Wan Rosmaiza Chai, Soon Ngiu Wan Yahya, Wan Nafisah Hui, Jan Tan Ibrahim, Norlinah |
| author_facet | Hashim, Hasnur Zaman Wan Musa, Wan Rosmaiza Chai, Soon Ngiu Wan Yahya, Wan Nafisah Hui, Jan Tan Ibrahim, Norlinah |
| author_sort | Hashim, Hasnur Zaman |
| building | IIUM Repository |
| collection | Online Access |
| description | Organophosphate insecticides have a triphasic effect
on the central nervous system, namely acute cholinergic
crisis, intermediate syndrome and delayed polyneuropathy.
Although acute organophosphate poisoning is relatively
common, case reports describing parkinsonism as a
neurological complication following an acute intoxication
are limited.
1
We report a case of parkinsonism noted on day
24 of admission following an acute severe organophosphate
poisoning which was successfully treated with benzhexol
and levodopa. Previously, response to levodopa was reported
to be poor in 3 patients studied by Bhatt et al
1whereas amantidine, dopamine agonist and bipiriden have been shown to be helpful.
2To the best of our knowledge, this is
the fi rst case of parkinsonism complicating organophosphate
poisoning which responded to levodopa and benzhexol
therapy. |
| first_indexed | 2025-11-14T14:58:39Z |
| format | Article |
| id | iium-18676 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T14:58:39Z |
| publishDate | 2011 |
| publisher | Academy of Medicine, Singapore |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-186762012-03-14T02:24:34Z http://irep.iium.edu.my/18676/ Parkinsonism complicating acute organophosphate insecticide poisoning Hashim, Hasnur Zaman Wan Musa, Wan Rosmaiza Chai, Soon Ngiu Wan Yahya, Wan Nafisah Hui, Jan Tan Ibrahim, Norlinah R Medicine (General) Organophosphate insecticides have a triphasic effect on the central nervous system, namely acute cholinergic crisis, intermediate syndrome and delayed polyneuropathy. Although acute organophosphate poisoning is relatively common, case reports describing parkinsonism as a neurological complication following an acute intoxication are limited. 1 We report a case of parkinsonism noted on day 24 of admission following an acute severe organophosphate poisoning which was successfully treated with benzhexol and levodopa. Previously, response to levodopa was reported to be poor in 3 patients studied by Bhatt et al 1whereas amantidine, dopamine agonist and bipiriden have been shown to be helpful. 2To the best of our knowledge, this is the fi rst case of parkinsonism complicating organophosphate poisoning which responded to levodopa and benzhexol therapy. Academy of Medicine, Singapore 2011 Article PeerReviewed application/pdf en http://irep.iium.edu.my/18676/1/V40N3p150.pdf Hashim, Hasnur Zaman and Wan Musa, Wan Rosmaiza and Chai, Soon Ngiu and Wan Yahya, Wan Nafisah and Hui, Jan Tan and Ibrahim, Norlinah (2011) Parkinsonism complicating acute organophosphate insecticide poisoning. Annals Academy of Medicine Singapore, 40 (3). pp. 150-151. ISSN 0304-4602 http://www.annals.edu.sg/pdf/40VolNo3Mar2011/V40N3p150.pdf |
| spellingShingle | R Medicine (General) Hashim, Hasnur Zaman Wan Musa, Wan Rosmaiza Chai, Soon Ngiu Wan Yahya, Wan Nafisah Hui, Jan Tan Ibrahim, Norlinah Parkinsonism complicating acute organophosphate insecticide poisoning |
| title | Parkinsonism complicating acute organophosphate insecticide poisoning |
| title_full | Parkinsonism complicating acute organophosphate insecticide poisoning |
| title_fullStr | Parkinsonism complicating acute organophosphate insecticide poisoning |
| title_full_unstemmed | Parkinsonism complicating acute organophosphate insecticide poisoning |
| title_short | Parkinsonism complicating acute organophosphate insecticide poisoning |
| title_sort | parkinsonism complicating acute organophosphate insecticide poisoning |
| topic | R Medicine (General) |
| url | http://irep.iium.edu.my/18676/ http://irep.iium.edu.my/18676/ http://irep.iium.edu.my/18676/1/V40N3p150.pdf |