Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology
The bioactive flavonoid compounds of spearmint (Mentha spicata L.) leaves were obtained by using supercritical carbon dioxide (SC-CO2) extraction. Extraction was carried out according to face-centred central composite design, and independent variables were pressure (100, 200 and 300 bar), temperatur...
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| Format: | Article |
| Language: | English English |
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Springer
2012
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| Online Access: | http://irep.iium.edu.my/17932/ http://irep.iium.edu.my/17932/1/Mandana.htm http://irep.iium.edu.my/17932/3/Optimization_of_Supercritical_Carbon_Dioxide_Extraction_of_Bioactive_Flavonoid_Compounds_from_Spearmint_%28Mentha_spicata_L.%29_Leaves_by_Using_Response_Surface_Methodology.pdf |
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| author | Bimakr, Mandana Abdul Rahman, Russly Ganjloo, Ali Taip, Farah Saleena Md Salleh, Liza Sarker, Md. Zaidul Islam |
| author_facet | Bimakr, Mandana Abdul Rahman, Russly Ganjloo, Ali Taip, Farah Saleena Md Salleh, Liza Sarker, Md. Zaidul Islam |
| author_sort | Bimakr, Mandana |
| building | IIUM Repository |
| collection | Online Access |
| description | The bioactive flavonoid compounds of spearmint (Mentha spicata L.) leaves were obtained by using supercritical carbon dioxide (SC-CO2) extraction. Extraction was carried out according to face-centred central composite design, and independent variables were pressure (100, 200 and 300 bar), temperature (40, 50 and 60 °C) and co-solvent amount (3, 6 and 9 g/min). The extraction process was optimized by using response surface methodology for the highest crude extraction yield of bioactive flavonoid compounds. The optimal conditions were identified as 209.39 bar pressure, 50.00 °C temperature and 7.39 g/min co-solvent amount. The obtained extract under optimum SC-CO2 condition was analysed by high-performance liquid chromatography. Seven bioactive flavonoids including catechin, epicatechin, rutin, luteolin, myricetin, apigenin and naringenin were identified as major compounds. The results of quantification showed that spearmint leaves are potential source of antioxidant compounds. |
| first_indexed | 2025-11-14T14:56:57Z |
| format | Article |
| id | iium-17932 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T14:56:57Z |
| publishDate | 2012 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-179322016-12-15T07:13:55Z http://irep.iium.edu.my/17932/ Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology Bimakr, Mandana Abdul Rahman, Russly Ganjloo, Ali Taip, Farah Saleena Md Salleh, Liza Sarker, Md. Zaidul Islam QD Chemistry The bioactive flavonoid compounds of spearmint (Mentha spicata L.) leaves were obtained by using supercritical carbon dioxide (SC-CO2) extraction. Extraction was carried out according to face-centred central composite design, and independent variables were pressure (100, 200 and 300 bar), temperature (40, 50 and 60 °C) and co-solvent amount (3, 6 and 9 g/min). The extraction process was optimized by using response surface methodology for the highest crude extraction yield of bioactive flavonoid compounds. The optimal conditions were identified as 209.39 bar pressure, 50.00 °C temperature and 7.39 g/min co-solvent amount. The obtained extract under optimum SC-CO2 condition was analysed by high-performance liquid chromatography. Seven bioactive flavonoids including catechin, epicatechin, rutin, luteolin, myricetin, apigenin and naringenin were identified as major compounds. The results of quantification showed that spearmint leaves are potential source of antioxidant compounds. Springer 2012-04-29 Article PeerReviewed application/pdf en http://irep.iium.edu.my/17932/1/Mandana.htm application/pdf en http://irep.iium.edu.my/17932/3/Optimization_of_Supercritical_Carbon_Dioxide_Extraction_of_Bioactive_Flavonoid_Compounds_from_Spearmint_%28Mentha_spicata_L.%29_Leaves_by_Using_Response_Surface_Methodology.pdf Bimakr, Mandana and Abdul Rahman, Russly and Ganjloo, Ali and Taip, Farah Saleena and Md Salleh, Liza and Sarker, Md. Zaidul Islam (2012) Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology. Food and Bioprocess Technology, 5 (3). pp. 912-920. ISSN 1935-5130 http://www.springer.com/food+science/journal/11947 DOI:10.1007/s11947-010-0504-4 |
| spellingShingle | QD Chemistry Bimakr, Mandana Abdul Rahman, Russly Ganjloo, Ali Taip, Farah Saleena Md Salleh, Liza Sarker, Md. Zaidul Islam Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology |
| title | Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology |
| title_full | Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology |
| title_fullStr | Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology |
| title_full_unstemmed | Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology |
| title_short | Optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (Mentha Spicata l.) leaves by using response surface methodology |
| title_sort | optimization of supercritical carbon dioxide extraction of bioactive flavonoid compounds from spearmint (mentha spicata l.) leaves by using response surface methodology |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/17932/ http://irep.iium.edu.my/17932/ http://irep.iium.edu.my/17932/ http://irep.iium.edu.my/17932/1/Mandana.htm http://irep.iium.edu.my/17932/3/Optimization_of_Supercritical_Carbon_Dioxide_Extraction_of_Bioactive_Flavonoid_Compounds_from_Spearmint_%28Mentha_spicata_L.%29_Leaves_by_Using_Response_Surface_Methodology.pdf |