Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells
Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in plants like rice bran. The production of myo-inositol phosphate intermediates has received much attention due to the remarkable potential health benefits offered by the compounds. In this study, the cytotoxicity of the parti...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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IIUM Press
2011
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| Online Access: | http://irep.iium.edu.my/17382/ http://irep.iium.edu.my/17382/1/priliminary.pdf |
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| author | Yusoff, Narazah Mohd Nuge, Tamrin Zainan, Nur Hidayah Hashim, Yumi Zuhanis Has-Yun Jamal, Parveen Meor Hussin, Anis Shobirin Farouk, Abd Alaziem Salleh, H.M. |
| author_facet | Yusoff, Narazah Mohd Nuge, Tamrin Zainan, Nur Hidayah Hashim, Yumi Zuhanis Has-Yun Jamal, Parveen Meor Hussin, Anis Shobirin Farouk, Abd Alaziem Salleh, H.M. |
| author_sort | Yusoff, Narazah Mohd |
| building | IIUM Repository |
| collection | Online Access |
| description | Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in
plants like rice bran. The production of myo-inositol phosphate intermediates has
received much attention due to the remarkable potential health benefits offered by the
compounds. In this study, the cytotoxicity of the partially purified myo-inositol
phosphate fractions and commercial IP1 and IP6 were investigated against MCF-7 breast
cancer cell lines. The study showed that the commercial standard IP1 and IP6 showed
good inhibition towards the MCF-7 cell line. The MCF-7 cells growth was inhibited in
minimum concentration of myo-inositol phosphates (<1000 μg/ml). However, no
inhibition observed on the MCF-7 cell line by the myo-inositol phosphates fractions
partially purified from rice bran at concentration <1000 g/ml. The inhibition of MCF-7
was only observed at concentration more than 30 mg/ml with more than 40% cells were
inhibited. This indicates that the partially purified rice bran myo-inositol phosphates
degraded by ASUIA279 phytase on MCF-7 breast cancer cells exhibit positive results
towards the inhibition of cancer cells growth at relatively high concentration. |
| first_indexed | 2025-11-14T14:55:29Z |
| format | Article |
| id | iium-17382 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T14:55:29Z |
| publishDate | 2011 |
| publisher | IIUM Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-173822012-01-30T07:08:10Z http://irep.iium.edu.my/17382/ Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells Yusoff, Narazah Mohd Nuge, Tamrin Zainan, Nur Hidayah Hashim, Yumi Zuhanis Has-Yun Jamal, Parveen Meor Hussin, Anis Shobirin Farouk, Abd Alaziem Salleh, H.M. QH301 Biology Phytate or myo-inositol hexakisphosphates (IP6) is widely distributed in plants like rice bran. The production of myo-inositol phosphate intermediates has received much attention due to the remarkable potential health benefits offered by the compounds. In this study, the cytotoxicity of the partially purified myo-inositol phosphate fractions and commercial IP1 and IP6 were investigated against MCF-7 breast cancer cell lines. The study showed that the commercial standard IP1 and IP6 showed good inhibition towards the MCF-7 cell line. The MCF-7 cells growth was inhibited in minimum concentration of myo-inositol phosphates (<1000 μg/ml). However, no inhibition observed on the MCF-7 cell line by the myo-inositol phosphates fractions partially purified from rice bran at concentration <1000 g/ml. The inhibition of MCF-7 was only observed at concentration more than 30 mg/ml with more than 40% cells were inhibited. This indicates that the partially purified rice bran myo-inositol phosphates degraded by ASUIA279 phytase on MCF-7 breast cancer cells exhibit positive results towards the inhibition of cancer cells growth at relatively high concentration. IIUM Press 2011 Article PeerReviewed application/pdf en http://irep.iium.edu.my/17382/1/priliminary.pdf Yusoff, Narazah Mohd and Nuge, Tamrin and Zainan, Nur Hidayah and Hashim, Yumi Zuhanis Has-Yun and Jamal, Parveen and Meor Hussin, Anis Shobirin and Farouk, Abd Alaziem and Salleh, H.M. (2011) Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells. IIUM Engineering Journal, 12 (4). pp. 1-11. ISSN 1511-788X |
| spellingShingle | QH301 Biology Yusoff, Narazah Mohd Nuge, Tamrin Zainan, Nur Hidayah Hashim, Yumi Zuhanis Has-Yun Jamal, Parveen Meor Hussin, Anis Shobirin Farouk, Abd Alaziem Salleh, H.M. Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells |
| title | Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells |
| title_full | Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells |
| title_fullStr | Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells |
| title_full_unstemmed | Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells |
| title_short | Preliminary investigation of MYO-INOSITOL phosphates produced by ASUIA279PHYTASE on MCF-7 cancer cells |
| title_sort | preliminary investigation of myo-inositol phosphates produced by asuia279phytase on mcf-7 cancer cells |
| topic | QH301 Biology |
| url | http://irep.iium.edu.my/17382/ http://irep.iium.edu.my/17382/1/priliminary.pdf |