Prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients
Introduction: This study aims to determine the prevalence and the types of menstrual disorders among patients with systemic lupus erythematosus (SLE) and to identify factors that influence their development. Methods: 61 patients with SLE were enrolled into a cross-sectional, observational stud...
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| Format: | Article |
| Language: | English |
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Singapore Medical Association
2008
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| Online Access: | http://irep.iium.edu.my/17142/ http://irep.iium.edu.my/17142/1/Prevalence_and_Risk_Factors_for_Menstrual.pdf |
| _version_ | 1848777998977728512 |
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| author | Mohd Shah, Azarisman Shah NNA, Fatnoon D, Zainal |
| author_facet | Mohd Shah, Azarisman Shah NNA, Fatnoon D, Zainal |
| author_sort | Mohd Shah, Azarisman Shah |
| building | IIUM Repository |
| collection | Online Access |
| description | Introduction: This study aims to determine the
prevalence and the types of menstrual disorders
among patients with systemic lupus erythematosus
(SLE) and to identify factors that influence their
development.
Methods: 61 patients with SLE were enrolled
into a cross-sectional, observational study at the
medical outpatient clinic, Hospital Universiti
Sains Malaysia. A total of 120 healthy women were
selected randomly to act as the control group. A
questionnaire was administered, vital signs were
recorded, and blood was evaluated for routine
investigations. A review of past medical records
was also undertaken.
Results: The mean age and standard deviation
for the study group was 33.23 +/- 10.96 years,
the majority being ethnic Malays. 75 percent
had a severe SLE disease activity index score
on initial presentation, and 59 percent were
on cyclophosphamide. 49 percent of the study
population had menstrual irregularities, of
which 60 percent had sustained amenorrhoea.
Nine patients with sustained amenorrhoea had
hormonal assays, which confirmed the diagnosis
of premature menopause.
Conclusion: This study showed that SLE patients
had a higher risk of developing menstrual
irregularities compared to the normal/healthy
population. The risk was higher in the older age
group (greater than 30 years old) and those on
cyclophosphamide therapy, especially those with
a cumulative dose of more than 10 g. Sustained
amenorrhoea was the commonest irregularity
and a majority of them had confirmed premature
menopause. |
| first_indexed | 2025-11-14T14:54:54Z |
| format | Article |
| id | iium-17142 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T14:54:54Z |
| publishDate | 2008 |
| publisher | Singapore Medical Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-171422012-01-26T08:42:44Z http://irep.iium.edu.my/17142/ Prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients Mohd Shah, Azarisman Shah NNA, Fatnoon D, Zainal RC Internal medicine Introduction: This study aims to determine the prevalence and the types of menstrual disorders among patients with systemic lupus erythematosus (SLE) and to identify factors that influence their development. Methods: 61 patients with SLE were enrolled into a cross-sectional, observational study at the medical outpatient clinic, Hospital Universiti Sains Malaysia. A total of 120 healthy women were selected randomly to act as the control group. A questionnaire was administered, vital signs were recorded, and blood was evaluated for routine investigations. A review of past medical records was also undertaken. Results: The mean age and standard deviation for the study group was 33.23 +/- 10.96 years, the majority being ethnic Malays. 75 percent had a severe SLE disease activity index score on initial presentation, and 59 percent were on cyclophosphamide. 49 percent of the study population had menstrual irregularities, of which 60 percent had sustained amenorrhoea. Nine patients with sustained amenorrhoea had hormonal assays, which confirmed the diagnosis of premature menopause. Conclusion: This study showed that SLE patients had a higher risk of developing menstrual irregularities compared to the normal/healthy population. The risk was higher in the older age group (greater than 30 years old) and those on cyclophosphamide therapy, especially those with a cumulative dose of more than 10 g. Sustained amenorrhoea was the commonest irregularity and a majority of them had confirmed premature menopause. Singapore Medical Association 2008 Article PeerReviewed application/pdf en http://irep.iium.edu.my/17142/1/Prevalence_and_Risk_Factors_for_Menstrual.pdf Mohd Shah, Azarisman Shah and NNA, Fatnoon and D, Zainal (2008) Prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients. Singapore Medical Journal, 49(5) (413). ISSN 0037-5675 http://smj.sma.org.sg/smjcurrent.html |
| spellingShingle | RC Internal medicine Mohd Shah, Azarisman Shah NNA, Fatnoon D, Zainal Prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients |
| title | Prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients |
| title_full | Prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients |
| title_fullStr | Prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients |
| title_full_unstemmed | Prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients |
| title_short | Prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients |
| title_sort | prevalence and risk factors for menstrual disorders among systemic lupus rythematosus patients |
| topic | RC Internal medicine |
| url | http://irep.iium.edu.my/17142/ http://irep.iium.edu.my/17142/ http://irep.iium.edu.my/17142/1/Prevalence_and_Risk_Factors_for_Menstrual.pdf |