Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient for p53Ser46 phosphorylation

QR Code

Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient for p53Ser46 phosphorylation

The p53 tumor suppressor protein plays key roles in protecting cells from tumorigenesis. Phosphorylation of p53 at Ser46 (p53Ser46) is considered to be a crucial modification regulating p53- mediated apoptosis. Because the activity of p53 is impaired in most human cancers, restoration of wild-type p...

Full description

Bibliographic Details
Main Authors:	Teng, Ma, Yamada, Shumpei, Ichwan, Solachuddin J. A., Ohtani, Kiyoshi, Otsu, Megumi, Ikeda, Masa-Aki
Format:	Article
Language:	English
Published:	ELSEVIER 2012
Subjects:	RB Pathology
Online Access:	http://irep.iium.edu.my/13889/ http://irep.iium.edu.my/13889/1/Inability_of_p53-reactivating_compounds_Nutlin-3_and_RITA.pdf

Similar Items

Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells
by: Arief Ichwan, Solachuddin Jauhari, et al.
Published: (2006)

Defect in ser46 phosphorylation of p53 protein: a resistance mechanism against p53 gene transfer in oral squamos cell carcinoma cells
by: Arief Ichwan, Solachuddin Jauhari, et al.
Published: (2008)

Cooperation between ARID3A and p53 in the transcriptional activation of p21WAF1 in response to DNA damage
by: Lestari, Widya, et al.
Published: (2012)

Therapeutic targeting of p53-mediated apoptosis pathway in head and neck squamous cell carcinomas: current progress and challenges
by: Arief Ichwan, Solachuddin Jauhari, et al.
Published: (2012)

Redox regulation of p53, redox effectors regulated by p53: A subtle balance
by: Maillet, A., et al.
Published: (2012)

Silencing endogenous mutant P53 Using Sirna Induces P73-Mediated Apoptosis in Human Head And Neck Squamous Cell Carcinoma
by: Arief Ichwan, Solachuddin Jauhari, et al.
Published: (2011)

p53-Mdm2 interaction targeted therapy by Nutlin-3 on nasopharyngeal carcinoma cells / Voon Yee Lin
by: Voon, Yee Lin
Published: (2016)

Crosstalk between p53 and mitochondrial metabolism
by: Itahana, K., et al.
Published: (2014)

Critical role of ARID3B in the expression of pro-apoptotic p53-target genes and apoptosis
by: Pratama, Endrawan, et al.
Published: (2015)

Cofactor strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase
by: Maniam, Sandra, et al.
Published: (2015)

Immunohistochemical study of p53 expression in premalignant and malignant cervical neoplasms
by: Tan GC,, et al.
Published: (2007)

An investigation of p53’s differential activation of cell cycle arrest and apoptosis
by: Zhang, Yuan
Published: (2008)

The relationship of P53 gene mutation with clinicopathological characteristic in breast cancer
by: Amrank, Fitreena Anis
Published: (2016)

A preliminary study of p53 oncogene expression in lung samples
by: Rahman, Md.Tahminur
Published: (2003)

Involvement of the P53 pathway and P161NK4A in the pathogenesis of b-cell lymphomas
by: Zainuddin, Norafiza
Published: (2011)

Ranibizumab inhibits human tenon’s fibroblast proliferation via p21 dependent p53 mechanisms
by: Siti Munirah Md Noh,, et al.
Published: (2021)

The interplay between p53 and p21 tumor suppressor proteins in the transformation of colorectal adenoma to carcinoma.
by: Abdulamir, Ahmed Sahib, et al.
Published: (2008)

Small molecule inhibitors of the p53-MDM2 protein-protein interaction
by: Fitzgerald, Ross Patrick
Published: (2011)

Profiling post translational modification of histone and p53 in human breast carcinomas
by: Abdelghany, Magdy Korashy
Published: (2011)

Expression of p53 protein in premenopausal women as risk factors for breast cancer
by: Rashidah S,, et al.
Published: (2016)

p53-targeted cancer pharmacotherapy: move towards small molecule compounds
by: Kim, S., et al.
Published: (2011)

The expressions of Ret/PTC and p53 in normal, benign and malignant thyroid lesions
by: Omar, Effat, et al.
Published: (2005)

Gene Expression And Metabonomic Profilings In P53+/- Knockout Mice Following Diethylstilbestrol Treatment
by: Salleh, Mohd Nazil
Published: (2003)

Isolation and sequence analysis of p53 cDNA from human prostate tissue
by: Nur Diana, Anuar.
Published: (2005)

Ki67 and p53 expression in relation to clinicopathological features in phyllodes tumour of the breast
by: Ali, Nurul Atiah Mohd
Published: (2020)

Growth Suppression of non-small lung carcinoma cell H1299 transfected with p53 and p73beta
by: Hayati, Rahma Fitri, et al.
Published: (2010)

Growth suppression of non-small lung carcinoma cell H1299 transfected with p53 and p73B
by: Hayati, Rahma Fitri, et al.
Published: (2010)

p53 and p21 mRNA and protein expression in treated synthetic oestrogen in mouse transgenic animal model
by: Salleh, Mohd Nazil, et al.
Published: (2014)

RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner
by: Parvathaneni, Swetha, et al.
Published: (2017)

Production of recombinant p53 protein by PCR-based site directed mutagenesis of plasmid DNA
by: Bakhtiar, M. Taher, et al.
Published: (2010)

Inverse correlation between P53 and Bcl-2 expression in breast carcinoma of Malaysian patients
by: Mdzin, R, et al.
Published: (2012)

Analysis of sequencing in exon 8, 9 and 11 in human tumor suppressor gene, P53
by: Toh, Alan Kie Leong
Published: (2003)

Quantitative analysis of the expression of p53 gene in colorectal carcinoma by using real-time PCR
by: Bong, Ivyna Pau Ni, et al.
Published: (2006)

Eurycomanone induce apoptosis in HepG2 cells via up-regulation of p53
by: Zakaria, Yusmazura, et al.
Published: (2009)

Xanthorrhizol Induces Apoptosis Via the Up-regulation of Bax and p53 in HeLa Cells
by: Ismail, Norzila, et al.
Published: (2005)

Xanthorrhizol Induces Apoptosis Via the Up-regulation of Bax and p53 in HeLa Cells
by: Ismail, Norzila, et al.
Published: (2005)

Evaluating the p53 as diagnostic marker by using liquid based cervical sample in cervical carcinogenesis
by: Zin, Anani Aila Mat
Published: (2019)

53,000 boleh balik
by: Abd Malik, Mahaizura
Published: (2020)

Molecular genetic analysis in B-cell Lymphomas : a focus on the p53 pathway and p16INK4a
by: Zainuddin, Norafiza
Published: (2010)

Cooperation between ARID3A and p53 in the transcriptional activation of p21WAF1 in response to DNA damage
by: Lestari, Widya, et al.
Published: (2013)