Histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients
Changes affecting endothelial cells in the microcirculation of diabetic foot patients are important in the development of foot ulceration and subsequent failure to heal existing ulcers. Methods We studied 30 patients (10 control individuals, 10 with the neuropathic ulcer and 10 with neuroischa...
| Main Authors: | , , , |
|---|---|
| Format: | Proceeding Paper |
| Language: | English |
| Published: |
2011
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/13270/ http://irep.iium.edu.my/13270/1/poster_emsm.pdf |
| _version_ | 1848777543326367744 |
|---|---|
| author | Mohd Radzuan, Hazulin Myint, Yi Yi Tun, Ye Zulkifly, Ahmad Hafiz |
| author_facet | Mohd Radzuan, Hazulin Myint, Yi Yi Tun, Ye Zulkifly, Ahmad Hafiz |
| author_sort | Mohd Radzuan, Hazulin |
| building | IIUM Repository |
| collection | Online Access |
| description | Changes affecting endothelial cells in the microcirculation of diabetic foot patients are important in the development of foot ulceration and subsequent failure to heal existing ulcers.
Methods
We studied 30 patients (10 control individuals, 10 with the neuropathic ulcer and 10 with neuroischaemic ulcer). The specimens were taken using skin punch biopsy and were routinely processed for light microscopy. The mean endothelial cell count (ECC) was performed by calculating all the endothelial cells of the 3 selected arterioles in each slide of every patient. The mean endothelial cell thicknesses (ECT) of all endothelia were measured using the image analyzer.
Results
There were significant differences of ECC and ECT between the groups determined by one-way ANOVA (F(2,27) = 5.31, p = 0.01 and F(2,27) = 52.42, p < 0.01 respectivel)y. There was no significant differences of ECC and ECT between neuropathic and neuroischemic; p = 0.99 and p = 0.18 respectively.
Conclusion
The decrement of ECC and the increment of ECT among diabetic foot patients as compared to controls could be due to the alteration in the endothelial cell function and structure as the results of the metabolic disease. |
| first_indexed | 2025-11-14T14:47:39Z |
| format | Proceeding Paper |
| id | iium-13270 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T14:47:39Z |
| publishDate | 2011 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-132702020-10-15T07:49:06Z http://irep.iium.edu.my/13270/ Histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients Mohd Radzuan, Hazulin Myint, Yi Yi Tun, Ye Zulkifly, Ahmad Hafiz QM Human anatomy Changes affecting endothelial cells in the microcirculation of diabetic foot patients are important in the development of foot ulceration and subsequent failure to heal existing ulcers. Methods We studied 30 patients (10 control individuals, 10 with the neuropathic ulcer and 10 with neuroischaemic ulcer). The specimens were taken using skin punch biopsy and were routinely processed for light microscopy. The mean endothelial cell count (ECC) was performed by calculating all the endothelial cells of the 3 selected arterioles in each slide of every patient. The mean endothelial cell thicknesses (ECT) of all endothelia were measured using the image analyzer. Results There were significant differences of ECC and ECT between the groups determined by one-way ANOVA (F(2,27) = 5.31, p = 0.01 and F(2,27) = 52.42, p < 0.01 respectivel)y. There was no significant differences of ECC and ECT between neuropathic and neuroischemic; p = 0.99 and p = 0.18 respectively. Conclusion The decrement of ECC and the increment of ECT among diabetic foot patients as compared to controls could be due to the alteration in the endothelial cell function and structure as the results of the metabolic disease. 2011-12-21 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/13270/1/poster_emsm.pdf Mohd Radzuan, Hazulin and Myint, Yi Yi and Tun, Ye and Zulkifly, Ahmad Hafiz (2011) Histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients. In: 20th Scientific Conference of Microscopy Society of Malaysia , 20th to 22nd December 2011, Permaisuri resort, Port Dickson. |
| spellingShingle | QM Human anatomy Mohd Radzuan, Hazulin Myint, Yi Yi Tun, Ye Zulkifly, Ahmad Hafiz Histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients |
| title | Histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients |
| title_full | Histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients |
| title_fullStr | Histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients |
| title_full_unstemmed | Histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients |
| title_short | Histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients |
| title_sort | histomorphometric analysis of the endothelial cell in skin microvasculature among diabetic foot ulcer patients |
| topic | QM Human anatomy |
| url | http://irep.iium.edu.my/13270/ http://irep.iium.edu.my/13270/1/poster_emsm.pdf |