LL5 directs the translocation of Filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2

LL5 directs the translocation of Filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2

Phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulates at the leading edge of migrating cells and works, at least partially, as both a compass to indicate directionality and a hub for subsequent intracellular events. However, how PtdIns(3,4,5)P3 regulates the migratory machinery has n...

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Bibliographic Details
Main Authors: Takabayashi, Tetsuji, Xie, Min-Jue, Takeuchi, Seiji, Kawasaki, Motomi, Yagi, Hideshi, Okamoto, Masayuki, Rahman, Mohammad Tariqur, Malik, Fawzia, Kuroda, Kazuki, Kubota, Chikara, Fujieda, Shigeharu, Nagano, Takashi, Sato, Makoto
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology Inc. 2010
Subjects:
RC321 Neuroscience. Biological psychiatry. Neuropsychiatry
Online Access:http://irep.iium.edu.my/12444/
http://irep.iium.edu.my/12444/1/LL5B_Direct_the_translocation_of_filamin_A_sites.pdf

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