Primary plasma cell leukemia presented as progressive paraplegia: a case report
Plasma cell leukemia (PCL) is a rare plasma cell disorder. It is the leukemic variant of multiple myeloma. A 52-year-old man with an atypical presentation of primary plasma cell leukemia is reported. The patient presented with paraparesis which progressively worsened to paraplegia. MRI of the spine...
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| Format: | Article |
| Language: | English |
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Southern Medical Association
2009
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| Online Access: | http://irep.iium.edu.my/12330/ http://irep.iium.edu.my/12330/1/Primary_Plasma_Cell_Leukemia_Presented_as.33%5B1%5D.pdf |
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| author | Hasmoni, Mohamed Hadzri Abdul Wahid, Fadilah Cheong, Soon Keng |
| author_facet | Hasmoni, Mohamed Hadzri Abdul Wahid, Fadilah Cheong, Soon Keng |
| author_sort | Hasmoni, Mohamed Hadzri |
| building | IIUM Repository |
| collection | Online Access |
| description | Plasma cell leukemia (PCL) is a rare plasma cell disorder. It is the leukemic variant of multiple myeloma. A 52-year-old man with an atypical presentation of primary plasma cell leukemia is reported. The patient presented with paraparesis which progressively worsened to paraplegia. MRI of the spine showed an extradural mass causing cord compression and multiple bony erosions from soft tissue masses. Peripheral blood film examination and bone marrow aspiration showed numerous plasmablasts. Atypical cells expressed surface and cytoplasmic lambda light chain on immunochemical studies, surface CD45 and CD38. To our knowledge, primary PCL presenting with progressive paraplegia has not been reported in the literature.
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| first_indexed | 2025-11-14T14:45:48Z |
| format | Article |
| id | iium-12330 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T14:45:48Z |
| publishDate | 2009 |
| publisher | Southern Medical Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-123302011-12-27T23:06:44Z http://irep.iium.edu.my/12330/ Primary plasma cell leukemia presented as progressive paraplegia: a case report Hasmoni, Mohamed Hadzri Abdul Wahid, Fadilah Cheong, Soon Keng RC254 Neoplasms. Tumors. Oncology (including Cancer) Plasma cell leukemia (PCL) is a rare plasma cell disorder. It is the leukemic variant of multiple myeloma. A 52-year-old man with an atypical presentation of primary plasma cell leukemia is reported. The patient presented with paraparesis which progressively worsened to paraplegia. MRI of the spine showed an extradural mass causing cord compression and multiple bony erosions from soft tissue masses. Peripheral blood film examination and bone marrow aspiration showed numerous plasmablasts. Atypical cells expressed surface and cytoplasmic lambda light chain on immunochemical studies, surface CD45 and CD38. To our knowledge, primary PCL presenting with progressive paraplegia has not been reported in the literature. Southern Medical Association 2009-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/12330/1/Primary_Plasma_Cell_Leukemia_Presented_as.33%5B1%5D.pdf Hasmoni, Mohamed Hadzri and Abdul Wahid, Fadilah and Cheong, Soon Keng (2009) Primary plasma cell leukemia presented as progressive paraplegia: a case report. Southern Medical Journal, 102 (1). pp. 101-103. ISSN 0038-4348 (P), 1541-8243 (O) http://journals.lww.com/smajournalonline/Fulltext/2009/01000/Primary_Plasma_Cell_Leukemia_Presented_as.33.aspx# 10.1097/SMJ.0b013e31818018c1 |
| spellingShingle | RC254 Neoplasms. Tumors. Oncology (including Cancer) Hasmoni, Mohamed Hadzri Abdul Wahid, Fadilah Cheong, Soon Keng Primary plasma cell leukemia presented as progressive paraplegia: a case report |
| title | Primary plasma cell leukemia presented as progressive paraplegia: a case report |
| title_full | Primary plasma cell leukemia presented as progressive paraplegia: a case report |
| title_fullStr | Primary plasma cell leukemia presented as progressive paraplegia: a case report |
| title_full_unstemmed | Primary plasma cell leukemia presented as progressive paraplegia: a case report |
| title_short | Primary plasma cell leukemia presented as progressive paraplegia: a case report |
| title_sort | primary plasma cell leukemia presented as progressive paraplegia: a case report |
| topic | RC254 Neoplasms. Tumors. Oncology (including Cancer) |
| url | http://irep.iium.edu.my/12330/ http://irep.iium.edu.my/12330/ http://irep.iium.edu.my/12330/ http://irep.iium.edu.my/12330/1/Primary_Plasma_Cell_Leukemia_Presented_as.33%5B1%5D.pdf |