Bioactive constituents from the leaves of Melastoma Malabathricum L
Phytochemical and bioactivity studies of the leaves of Melastoma malabathricum L. (Melastomataceae) have been investigated. The n-hexane extract yielded α-amyrin, patriscabatrine and auranamide, ethyl acetate extract gave quercetin and quercitrin, and methanol extract gave quercitrin and kaempferol-...
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| Format: | Article |
| Language: | English |
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Universitas Islam Indonesia
2008
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| Online Access: | http://irep.iium.edu.my/1227/ http://irep.iium.edu.my/1227/1/Bioactive_Constituents_from_the_leaves_of_Melastoma_Malabathricum._L..pdf |
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| author | Darnis, Deny Susanti Mohd. Sirat, Hasnah Ahmad, Farediah Mat Ali, Rasadah |
| author_facet | Darnis, Deny Susanti Mohd. Sirat, Hasnah Ahmad, Farediah Mat Ali, Rasadah |
| author_sort | Darnis, Deny Susanti |
| building | IIUM Repository |
| collection | Online Access |
| description | Phytochemical and bioactivity studies of the leaves of Melastoma malabathricum L. (Melastomataceae) have been investigated. The n-hexane extract yielded α-amyrin, patriscabatrine and auranamide, ethyl acetate extract gave quercetin and quercitrin, and methanol extract gave quercitrin and kaempferol-3-O-(2”,6”-di-O-p-trans-coumaroyl)glucoside. The crude extracts and isolated compounds were screened for their antioxidant and cytotoxic activities. The antioxidant assay was carried out by FTC and DPPH radical scavenging method. Kaempferol-3-O-(2”,6”-di-Op- trans-coumaroyl)-glucoside, quercetin and quercitrin showed strong activities with inhibition more than 90% in the FTC method. Quercetin was found to be the most active as radical scavenger in DPPH method with IC50 of 0.69 µM. α-Amyrin and kaempferol-3-O-(2”,6”-di-O-p-transcoumaroyl) glucoside demonstrated the strongest activities in the anti-inflammatory assay of TPA mouse ear oedema with IC50 of 0.11 and 0.34 mM/ear, respectively. |
| first_indexed | 2025-11-14T14:20:11Z |
| format | Article |
| id | iium-1227 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T14:20:11Z |
| publishDate | 2008 |
| publisher | Universitas Islam Indonesia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-12272011-07-29T06:37:46Z http://irep.iium.edu.my/1227/ Bioactive constituents from the leaves of Melastoma Malabathricum L Darnis, Deny Susanti Mohd. Sirat, Hasnah Ahmad, Farediah Mat Ali, Rasadah Q Science (General) Phytochemical and bioactivity studies of the leaves of Melastoma malabathricum L. (Melastomataceae) have been investigated. The n-hexane extract yielded α-amyrin, patriscabatrine and auranamide, ethyl acetate extract gave quercetin and quercitrin, and methanol extract gave quercitrin and kaempferol-3-O-(2”,6”-di-O-p-trans-coumaroyl)glucoside. The crude extracts and isolated compounds were screened for their antioxidant and cytotoxic activities. The antioxidant assay was carried out by FTC and DPPH radical scavenging method. Kaempferol-3-O-(2”,6”-di-Op- trans-coumaroyl)-glucoside, quercetin and quercitrin showed strong activities with inhibition more than 90% in the FTC method. Quercetin was found to be the most active as radical scavenger in DPPH method with IC50 of 0.69 µM. α-Amyrin and kaempferol-3-O-(2”,6”-di-O-p-transcoumaroyl) glucoside demonstrated the strongest activities in the anti-inflammatory assay of TPA mouse ear oedema with IC50 of 0.11 and 0.34 mM/ear, respectively. Universitas Islam Indonesia 2008 Article PeerReviewed application/pdf en http://irep.iium.edu.my/1227/1/Bioactive_Constituents_from_the_leaves_of_Melastoma_Malabathricum._L..pdf Darnis, Deny Susanti and Mohd. Sirat, Hasnah and Ahmad, Farediah and Mat Ali, Rasadah (2008) Bioactive constituents from the leaves of Melastoma Malabathricum L. Jurnal Ilmiah Farmasi, 5 (1). pp. 1-8. http://journal.uii.ac.id/index.php/JIF/article/view/465 |
| spellingShingle | Q Science (General) Darnis, Deny Susanti Mohd. Sirat, Hasnah Ahmad, Farediah Mat Ali, Rasadah Bioactive constituents from the leaves of Melastoma Malabathricum L |
| title | Bioactive constituents from the leaves of Melastoma Malabathricum L |
| title_full | Bioactive constituents from the leaves of Melastoma Malabathricum L |
| title_fullStr | Bioactive constituents from the leaves of Melastoma Malabathricum L |
| title_full_unstemmed | Bioactive constituents from the leaves of Melastoma Malabathricum L |
| title_short | Bioactive constituents from the leaves of Melastoma Malabathricum L |
| title_sort | bioactive constituents from the leaves of melastoma malabathricum l |
| topic | Q Science (General) |
| url | http://irep.iium.edu.my/1227/ http://irep.iium.edu.my/1227/ http://irep.iium.edu.my/1227/1/Bioactive_Constituents_from_the_leaves_of_Melastoma_Malabathricum._L..pdf |