Bioactivities of a-mangostin from Garcinia malaccensis Hk.f
Guttiferae family is well known to have a wide range of phytochemical sontituents and bioactivities. A phytochemical investigation of Garcinia malaccensis leasd isolaton of a-mangostin, b-mangostin and a triterpenoid. a-Mangostin, a xanthone has a lot of health benefits. Many studies have been repor...
| Main Authors: | , , , , |
|---|---|
| Format: | Proceeding Paper |
| Language: | English English |
| Published: |
2010
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/12148/ http://irep.iium.edu.my/12148/1/Icastcover.pdf http://irep.iium.edu.my/12148/2/Icast2.pdf |
| _version_ | 1848777407770656768 |
|---|---|
| author | Zohri, Farah Syahidah A Bakhtiar, M. Taher Darnis, Deny Susanti Nakazibwe, Sauba Solachuddin Jauhari, Arief Ichwan |
| author_facet | Zohri, Farah Syahidah A Bakhtiar, M. Taher Darnis, Deny Susanti Nakazibwe, Sauba Solachuddin Jauhari, Arief Ichwan |
| author_sort | Zohri, Farah Syahidah A |
| building | IIUM Repository |
| collection | Online Access |
| description | Guttiferae family is well known to have a wide range of phytochemical sontituents and bioactivities. A phytochemical investigation of Garcinia malaccensis leasd isolaton of a-mangostin, b-mangostin and a triterpenoid. a-Mangostin, a xanthone has a lot of health benefits. Many studies have been reported to investigate the biological activities of a-mangostin. The present study was carried out to evaluate the antimicrobial, antioxidant and anticancer activities of a-mangostin. Its structural determination was done based on its spectroscopic analysis. a-Mangostin was tested for antimicrobial sensitivity via disc diffusion method against 4 bacteria. Results showed that S.aureus culture formed a clear inhibition zone. The diameter of zone of inhibition observed was 8 mm and minimum inhibition concentration (MBC)value was 0.1mg/mL, indicted that a-mangostin is a bacteriostatic and bactericidal agent which correlates to presence of hydroxyl group in its structure. In antioxidant properties tests, dot-blot DPPH staining showed a positive antioxidant activity of a-mangostin. In FTC method, a-mangosin was proved to be good lipid peroxidation inhibitor, whereas in DPPH free redical scevenging activity method, it has very weak scavening effects on free radicals. In antiproliferative assay, a-mangostin exhibited activity against K562 and showed different activity against HSC3 and H1299 cell lines. Against K562, it exerted the value of IC50 20ug/mL. This study can form a foundation for future studies in investigating of biological activities of-amangostin and developing the natural abundant in improving a healthy community. |
| first_indexed | 2025-11-14T14:45:30Z |
| format | Proceeding Paper |
| id | iium-12148 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T14:45:30Z |
| publishDate | 2010 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-121482014-12-09T01:37:26Z http://irep.iium.edu.my/12148/ Bioactivities of a-mangostin from Garcinia malaccensis Hk.f Zohri, Farah Syahidah A Bakhtiar, M. Taher Darnis, Deny Susanti Nakazibwe, Sauba Solachuddin Jauhari, Arief Ichwan Q Science (General) Guttiferae family is well known to have a wide range of phytochemical sontituents and bioactivities. A phytochemical investigation of Garcinia malaccensis leasd isolaton of a-mangostin, b-mangostin and a triterpenoid. a-Mangostin, a xanthone has a lot of health benefits. Many studies have been reported to investigate the biological activities of a-mangostin. The present study was carried out to evaluate the antimicrobial, antioxidant and anticancer activities of a-mangostin. Its structural determination was done based on its spectroscopic analysis. a-Mangostin was tested for antimicrobial sensitivity via disc diffusion method against 4 bacteria. Results showed that S.aureus culture formed a clear inhibition zone. The diameter of zone of inhibition observed was 8 mm and minimum inhibition concentration (MBC)value was 0.1mg/mL, indicted that a-mangostin is a bacteriostatic and bactericidal agent which correlates to presence of hydroxyl group in its structure. In antioxidant properties tests, dot-blot DPPH staining showed a positive antioxidant activity of a-mangostin. In FTC method, a-mangosin was proved to be good lipid peroxidation inhibitor, whereas in DPPH free redical scevenging activity method, it has very weak scavening effects on free radicals. In antiproliferative assay, a-mangostin exhibited activity against K562 and showed different activity against HSC3 and H1299 cell lines. Against K562, it exerted the value of IC50 20ug/mL. This study can form a foundation for future studies in investigating of biological activities of-amangostin and developing the natural abundant in improving a healthy community. 2010-11-27 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/12148/1/Icastcover.pdf application/pdf en http://irep.iium.edu.my/12148/2/Icast2.pdf Zohri, Farah Syahidah A and Bakhtiar, M. Taher and Darnis, Deny Susanti and Nakazibwe, Sauba and Solachuddin Jauhari, Arief Ichwan (2010) Bioactivities of a-mangostin from Garcinia malaccensis Hk.f. In: International Conference on Advancement in Science and Technology (iCAST2010): The Science of Traditional Practices in Health and Disease, 26-29 Nov 2010, Kuantan, Malaysia. (Unpublished) |
| spellingShingle | Q Science (General) Zohri, Farah Syahidah A Bakhtiar, M. Taher Darnis, Deny Susanti Nakazibwe, Sauba Solachuddin Jauhari, Arief Ichwan Bioactivities of a-mangostin from Garcinia malaccensis Hk.f |
| title | Bioactivities of a-mangostin from Garcinia malaccensis Hk.f |
| title_full | Bioactivities of a-mangostin from Garcinia malaccensis Hk.f |
| title_fullStr | Bioactivities of a-mangostin from Garcinia malaccensis Hk.f |
| title_full_unstemmed | Bioactivities of a-mangostin from Garcinia malaccensis Hk.f |
| title_short | Bioactivities of a-mangostin from Garcinia malaccensis Hk.f |
| title_sort | bioactivities of a-mangostin from garcinia malaccensis hk.f |
| topic | Q Science (General) |
| url | http://irep.iium.edu.my/12148/ http://irep.iium.edu.my/12148/1/Icastcover.pdf http://irep.iium.edu.my/12148/2/Icast2.pdf |