Study of cytotoxic activities of Rubraxanthone
Rubraxanthone is a prenylated xanthone that was isolated from Garcinia euginifolia (Guttiferae). It is having antimicrobial and antiplatelet activating factor activities. The research is aimed to study a cytotoxic activity of the compound by using in vitro cell culture technique. In order to evaluat...
| Main Authors: | , , |
|---|---|
| Format: | Proceeding Paper |
| Language: | English English |
| Published: |
2009
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/12122/ http://irep.iium.edu.my/12122/1/ICMC-Bandung-1.pdf http://irep.iium.edu.my/12122/2/bandungcover.pdf |
| _version_ | 1848777402894778368 |
|---|---|
| author | Bakhtiar, M. Taher Sawaneh, Fatoumata Darnis, Deny Susanti |
| author_facet | Bakhtiar, M. Taher Sawaneh, Fatoumata Darnis, Deny Susanti |
| author_sort | Bakhtiar, M. Taher |
| building | IIUM Repository |
| collection | Online Access |
| description | Rubraxanthone is a prenylated xanthone that was isolated from Garcinia euginifolia (Guttiferae). It is having antimicrobial and antiplatelet activating factor activities. The research is aimed to study a cytotoxic activity of the compound by using in vitro cell culture technique. In order to evaluate the activity against cancer, the compound is exposed for its activity against several cancerous cell lines. It is tested against breast (MCF-7), bone (Saos-2), cervix (SiHa and C33A), colorectal (HCT-116), esophageal (TE1 and TE2), rectum (SW837) cancer cells and normal fibroblast (NHDF). The cells were seeded in a 96-well plate a density of 2 x 10^5 cells/mL. The compound is being tested to confluent celss for two days. Antiproliverative activity is evaluated by 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazoliumbromide) (MTT) assay. It is found that the compound exhibits a moderate activity against all type of the cells. |
| first_indexed | 2025-11-14T14:45:25Z |
| format | Proceeding Paper |
| id | iium-12122 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T14:45:25Z |
| publishDate | 2009 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-121222014-12-09T01:42:19Z http://irep.iium.edu.my/12122/ Study of cytotoxic activities of Rubraxanthone Bakhtiar, M. Taher Sawaneh, Fatoumata Darnis, Deny Susanti Q Science (General) Rubraxanthone is a prenylated xanthone that was isolated from Garcinia euginifolia (Guttiferae). It is having antimicrobial and antiplatelet activating factor activities. The research is aimed to study a cytotoxic activity of the compound by using in vitro cell culture technique. In order to evaluate the activity against cancer, the compound is exposed for its activity against several cancerous cell lines. It is tested against breast (MCF-7), bone (Saos-2), cervix (SiHa and C33A), colorectal (HCT-116), esophageal (TE1 and TE2), rectum (SW837) cancer cells and normal fibroblast (NHDF). The cells were seeded in a 96-well plate a density of 2 x 10^5 cells/mL. The compound is being tested to confluent celss for two days. Antiproliverative activity is evaluated by 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazoliumbromide) (MTT) assay. It is found that the compound exhibits a moderate activity against all type of the cells. 2009-08-06 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/12122/1/ICMC-Bandung-1.pdf application/pdf en http://irep.iium.edu.my/12122/2/bandungcover.pdf Bakhtiar, M. Taher and Sawaneh, Fatoumata and Darnis, Deny Susanti (2009) Study of cytotoxic activities of Rubraxanthone. In: Bandung International Conference on Medicinal Chemistry, 6-8 August 2009, Bandung, Indonesia. http://www.icmc2009.fa.itb.ac.id/ |
| spellingShingle | Q Science (General) Bakhtiar, M. Taher Sawaneh, Fatoumata Darnis, Deny Susanti Study of cytotoxic activities of Rubraxanthone |
| title | Study of cytotoxic activities of Rubraxanthone |
| title_full | Study of cytotoxic activities of Rubraxanthone |
| title_fullStr | Study of cytotoxic activities of Rubraxanthone |
| title_full_unstemmed | Study of cytotoxic activities of Rubraxanthone |
| title_short | Study of cytotoxic activities of Rubraxanthone |
| title_sort | study of cytotoxic activities of rubraxanthone |
| topic | Q Science (General) |
| url | http://irep.iium.edu.my/12122/ http://irep.iium.edu.my/12122/ http://irep.iium.edu.my/12122/1/ICMC-Bandung-1.pdf http://irep.iium.edu.my/12122/2/bandungcover.pdf |