The effect of Cinnamtannin B1 on cell proliferation and glucose uptake of 3T3-L1 cells
The effects of cinnamtannin B1 on cell proliferation and glucose uptake of 3T3-L1 cells were examined. Cinnamtannin B1 promoted cell proliferation of 3T3-L1 adipocytes at a concentration range between 0.11-0.17 mM. The effect of cinnamtannin B1 on cellular 2-deoxy-D-[1-3H] glucose uptake in differen...
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| Format: | Article |
| Language: | English |
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Natural Product, Inc.
2007
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| Online Access: | http://irep.iium.edu.my/12083/ http://irep.iium.edu.my/12083/1/Article-NPC-2-1-61-2007.pdf |
| _version_ | 1848777395979419648 |
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| author | Bakhtiar, M. Taher Abdul Majid, Fadzilah Adibah Sarmidi, Mohamad Roji |
| author_facet | Bakhtiar, M. Taher Abdul Majid, Fadzilah Adibah Sarmidi, Mohamad Roji |
| author_sort | Bakhtiar, M. Taher |
| building | IIUM Repository |
| collection | Online Access |
| description | The effects of cinnamtannin B1 on cell proliferation and glucose uptake of 3T3-L1 cells were examined. Cinnamtannin B1 promoted cell proliferation of 3T3-L1 adipocytes at a concentration range between 0.11-0.17 mM. The effect of cinnamtannin B1 on cellular 2-deoxy-D-[1-3H] glucose uptake in differentiated 3T3-L1 adipocytes, following treatment with a 0.11 mM concentration of cinnamtannin B1 for 15, 30 and 60 minutes, was an increase in the glucose uptake from a basal value to 702.0,1111.0 and 2226.0 cpm, respectively (p<0.005). The comparable glucose uptakes with insulin treatment were 660.0, 1039.0 and 2135.0 cpm, respectively. Wortmannin and cytochalasin B were found to inhibit cinnamtannin B1-stimulated glucose uptake, but sodium orthovanadate increased the glucose uptake. |
| first_indexed | 2025-11-14T14:45:19Z |
| format | Article |
| id | iium-12083 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T14:45:19Z |
| publishDate | 2007 |
| publisher | Natural Product, Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-120832014-12-09T00:26:45Z http://irep.iium.edu.my/12083/ The effect of Cinnamtannin B1 on cell proliferation and glucose uptake of 3T3-L1 cells Bakhtiar, M. Taher Abdul Majid, Fadzilah Adibah Sarmidi, Mohamad Roji RS Pharmacy and materia medica The effects of cinnamtannin B1 on cell proliferation and glucose uptake of 3T3-L1 cells were examined. Cinnamtannin B1 promoted cell proliferation of 3T3-L1 adipocytes at a concentration range between 0.11-0.17 mM. The effect of cinnamtannin B1 on cellular 2-deoxy-D-[1-3H] glucose uptake in differentiated 3T3-L1 adipocytes, following treatment with a 0.11 mM concentration of cinnamtannin B1 for 15, 30 and 60 minutes, was an increase in the glucose uptake from a basal value to 702.0,1111.0 and 2226.0 cpm, respectively (p<0.005). The comparable glucose uptakes with insulin treatment were 660.0, 1039.0 and 2135.0 cpm, respectively. Wortmannin and cytochalasin B were found to inhibit cinnamtannin B1-stimulated glucose uptake, but sodium orthovanadate increased the glucose uptake. Natural Product, Inc. 2007 Article PeerReviewed application/pdf en http://irep.iium.edu.my/12083/1/Article-NPC-2-1-61-2007.pdf Bakhtiar, M. Taher and Abdul Majid, Fadzilah Adibah and Sarmidi, Mohamad Roji (2007) The effect of Cinnamtannin B1 on cell proliferation and glucose uptake of 3T3-L1 cells. Natural Product Communications, 2 (1). pp. 61-66. ISSN 1934-578X http://www.naturalproduct.us. |
| spellingShingle | RS Pharmacy and materia medica Bakhtiar, M. Taher Abdul Majid, Fadzilah Adibah Sarmidi, Mohamad Roji The effect of Cinnamtannin B1 on cell proliferation and glucose uptake of 3T3-L1 cells |
| title | The effect of Cinnamtannin B1 on cell proliferation and
glucose uptake of 3T3-L1 cells |
| title_full | The effect of Cinnamtannin B1 on cell proliferation and
glucose uptake of 3T3-L1 cells |
| title_fullStr | The effect of Cinnamtannin B1 on cell proliferation and
glucose uptake of 3T3-L1 cells |
| title_full_unstemmed | The effect of Cinnamtannin B1 on cell proliferation and
glucose uptake of 3T3-L1 cells |
| title_short | The effect of Cinnamtannin B1 on cell proliferation and
glucose uptake of 3T3-L1 cells |
| title_sort | effect of cinnamtannin b1 on cell proliferation and
glucose uptake of 3t3-l1 cells |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/12083/ http://irep.iium.edu.my/12083/ http://irep.iium.edu.my/12083/1/Article-NPC-2-1-61-2007.pdf |