In vitro inhibitory effect of Rubraxanthone isolated from Garcinia psrvifolia on platelet- Activating factor receptor binding
Rubraxanthone and isocowanol isolated from Garcinia parvifolia Miq. were investigated for their inhibitory effects on platelet-activating factor (PAF) binding to rabbit platelets using 3H-PAF as a ligand. Rubraxanthone showed a strong inhibition with IC 50 value of 18.2 microM. The IC 50 values of m...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Verlagsgruppe
2002
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/12052/ http://irep.iium.edu.my/12052/1/Plantamedica.pdf |
| _version_ | 1848777390951497728 |
|---|---|
| author | Jantan, Ibrahim Md Pisar, Mazura Idris, Muhammad Sum Bakhtiar, M. Taher Mat Ali, Rasadah |
| author_facet | Jantan, Ibrahim Md Pisar, Mazura Idris, Muhammad Sum Bakhtiar, M. Taher Mat Ali, Rasadah |
| author_sort | Jantan, Ibrahim |
| building | IIUM Repository |
| collection | Online Access |
| description | Rubraxanthone and isocowanol isolated from Garcinia parvifolia Miq. were investigated for their inhibitory effects on platelet-activating factor (PAF) binding to rabbit platelets using 3H-PAF as a ligand. Rubraxanthone showed a strong inhibition with IC 50 value of 18.2 microM. The IC 50 values of macluraxanthone, 6-deoxyjacareubin, 2-(3-methylbut-2-enyl)-1,3,5-trihydroxyxanthone, 2-(3-methylbut-2-enyl)-1,3,5,6-tetrahydroxyxanthone and 1,3,5-trihydroxy-6,6'-dimethylpyrano(2',3':6,7)-4-(1,1-dimethylprop-2-enyl)-xanthone were also determined for comparison. In the course of our study on structure-activity relationship of xanthones, the results revealed that a geranyl group substituted at C-8 was beneficial to the binding while a hydroxylated prenyl group at C-4 resulted in a significant loss in binding to the PAF receptor. |
| first_indexed | 2025-11-14T14:45:14Z |
| format | Article |
| id | iium-12052 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T14:45:14Z |
| publishDate | 2002 |
| publisher | Thieme Verlagsgruppe |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-120522014-12-09T00:29:00Z http://irep.iium.edu.my/12052/ In vitro inhibitory effect of Rubraxanthone isolated from Garcinia psrvifolia on platelet- Activating factor receptor binding Jantan, Ibrahim Md Pisar, Mazura Idris, Muhammad Sum Bakhtiar, M. Taher Mat Ali, Rasadah RS Pharmacy and materia medica Rubraxanthone and isocowanol isolated from Garcinia parvifolia Miq. were investigated for their inhibitory effects on platelet-activating factor (PAF) binding to rabbit platelets using 3H-PAF as a ligand. Rubraxanthone showed a strong inhibition with IC 50 value of 18.2 microM. The IC 50 values of macluraxanthone, 6-deoxyjacareubin, 2-(3-methylbut-2-enyl)-1,3,5-trihydroxyxanthone, 2-(3-methylbut-2-enyl)-1,3,5,6-tetrahydroxyxanthone and 1,3,5-trihydroxy-6,6'-dimethylpyrano(2',3':6,7)-4-(1,1-dimethylprop-2-enyl)-xanthone were also determined for comparison. In the course of our study on structure-activity relationship of xanthones, the results revealed that a geranyl group substituted at C-8 was beneficial to the binding while a hydroxylated prenyl group at C-4 resulted in a significant loss in binding to the PAF receptor. Thieme Verlagsgruppe 2002 Article PeerReviewed application/pdf en http://irep.iium.edu.my/12052/1/Plantamedica.pdf Jantan, Ibrahim and Md Pisar, Mazura and Idris, Muhammad Sum and Bakhtiar, M. Taher and Mat Ali, Rasadah (2002) In vitro inhibitory effect of Rubraxanthone isolated from Garcinia psrvifolia on platelet- Activating factor receptor binding. Planta Medica, 68. pp. 1133-1134. ISSN 0032-0943 http://www.thieme.de/plantamedica/ |
| spellingShingle | RS Pharmacy and materia medica Jantan, Ibrahim Md Pisar, Mazura Idris, Muhammad Sum Bakhtiar, M. Taher Mat Ali, Rasadah In vitro inhibitory effect of Rubraxanthone isolated from Garcinia psrvifolia on platelet- Activating factor receptor binding |
| title | In vitro inhibitory effect of Rubraxanthone isolated from
Garcinia psrvifolia on platelet- Activating factor receptor binding |
| title_full | In vitro inhibitory effect of Rubraxanthone isolated from
Garcinia psrvifolia on platelet- Activating factor receptor binding |
| title_fullStr | In vitro inhibitory effect of Rubraxanthone isolated from
Garcinia psrvifolia on platelet- Activating factor receptor binding |
| title_full_unstemmed | In vitro inhibitory effect of Rubraxanthone isolated from
Garcinia psrvifolia on platelet- Activating factor receptor binding |
| title_short | In vitro inhibitory effect of Rubraxanthone isolated from
Garcinia psrvifolia on platelet- Activating factor receptor binding |
| title_sort | in vitro inhibitory effect of rubraxanthone isolated from
garcinia psrvifolia on platelet- activating factor receptor binding |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/12052/ http://irep.iium.edu.my/12052/ http://irep.iium.edu.my/12052/1/Plantamedica.pdf |