Risk factors associated with development of dengue haemorrhagic fever or dengue shock syndrome in adults in Hospital Tengku Ampuan Afzan Kuantan
A retrospective study was conducted to investigate 183 serologically-confirmed cases of dengue fever (DF) admitted from October 2004 to March 2005 in a large hospital in Pahang. Clinical and laboratory features, progress and outcome of these patients were analysed in order to identify risk factors a...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Malaysian Medical Associations
2009
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/1126/ http://irep.iium.edu.my/1126/1/Risk_Factors_Associated_with_Development_of_Dengue.pdf |
| _version_ | 1848775801976127488 |
|---|---|
| author | Tee, H. P. How, Soon Hin Ab Rahman, Jamalludin Mohamad Nor, Fariz Safhan M., Mohd Sapian Kuan, Yeh Chunn S., Sapari |
| author_facet | Tee, H. P. How, Soon Hin Ab Rahman, Jamalludin Mohamad Nor, Fariz Safhan M., Mohd Sapian Kuan, Yeh Chunn S., Sapari |
| author_sort | Tee, H. P. |
| building | IIUM Repository |
| collection | Online Access |
| description | A retrospective study was conducted to investigate 183 serologically-confirmed cases of dengue fever (DF) admitted from October 2004 to March 2005 in a large hospital in Pahang. Clinical and laboratory features, progress and outcome of these patients were analysed in order to identify risk factors associated with development of dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS). Individually, we found that older patients, secondary dengue infection, high baseline haematocrit levels, low platelet levels and prolonged activated partial thromboplastin time (APTT) ratio were significant associations with bleeding tendencies. Of these risk factors, haematocrit and APTT ratio were two independent significant risk factors on multivariate analysis. Older patients with primary infection and younger patients with secondary infection had significant bleeding tendencies. We also verified the validity of the haematocrit levels suggested as cut-off levels for plasma leakage for the Malaysian population by Malaysian Clinical Practice Guidelines for Dengue Infection in Adults (2003). |
| first_indexed | 2025-11-14T14:19:59Z |
| format | Article |
| id | iium-1126 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T14:19:59Z |
| publishDate | 2009 |
| publisher | Malaysian Medical Associations |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-11262016-03-10T03:59:46Z http://irep.iium.edu.my/1126/ Risk factors associated with development of dengue haemorrhagic fever or dengue shock syndrome in adults in Hospital Tengku Ampuan Afzan Kuantan Tee, H. P. How, Soon Hin Ab Rahman, Jamalludin Mohamad Nor, Fariz Safhan M., Mohd Sapian Kuan, Yeh Chunn S., Sapari R Medicine (General) RA Public aspects of medicine A retrospective study was conducted to investigate 183 serologically-confirmed cases of dengue fever (DF) admitted from October 2004 to March 2005 in a large hospital in Pahang. Clinical and laboratory features, progress and outcome of these patients were analysed in order to identify risk factors associated with development of dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS). Individually, we found that older patients, secondary dengue infection, high baseline haematocrit levels, low platelet levels and prolonged activated partial thromboplastin time (APTT) ratio were significant associations with bleeding tendencies. Of these risk factors, haematocrit and APTT ratio were two independent significant risk factors on multivariate analysis. Older patients with primary infection and younger patients with secondary infection had significant bleeding tendencies. We also verified the validity of the haematocrit levels suggested as cut-off levels for plasma leakage for the Malaysian population by Malaysian Clinical Practice Guidelines for Dengue Infection in Adults (2003). Malaysian Medical Associations 2009-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/1126/1/Risk_Factors_Associated_with_Development_of_Dengue.pdf Tee, H. P. and How, Soon Hin and Ab Rahman, Jamalludin and Mohamad Nor, Fariz Safhan and M., Mohd Sapian and Kuan, Yeh Chunn and S., Sapari (2009) Risk factors associated with development of dengue haemorrhagic fever or dengue shock syndrome in adults in Hospital Tengku Ampuan Afzan Kuantan. Medical Journal of Malaysia, 64 (4). pp. 263-267. ISSN 0300-5283 http://www.e-mjm.org/2009/v64n4/index.html |
| spellingShingle | R Medicine (General) RA Public aspects of medicine Tee, H. P. How, Soon Hin Ab Rahman, Jamalludin Mohamad Nor, Fariz Safhan M., Mohd Sapian Kuan, Yeh Chunn S., Sapari Risk factors associated with development of dengue haemorrhagic fever or dengue shock syndrome in adults in Hospital Tengku Ampuan Afzan Kuantan |
| title | Risk factors associated with development of dengue haemorrhagic fever or dengue shock syndrome in adults in Hospital Tengku Ampuan Afzan Kuantan |
| title_full | Risk factors associated with development of dengue haemorrhagic fever or dengue shock syndrome in adults in Hospital Tengku Ampuan Afzan Kuantan |
| title_fullStr | Risk factors associated with development of dengue haemorrhagic fever or dengue shock syndrome in adults in Hospital Tengku Ampuan Afzan Kuantan |
| title_full_unstemmed | Risk factors associated with development of dengue haemorrhagic fever or dengue shock syndrome in adults in Hospital Tengku Ampuan Afzan Kuantan |
| title_short | Risk factors associated with development of dengue haemorrhagic fever or dengue shock syndrome in adults in Hospital Tengku Ampuan Afzan Kuantan |
| title_sort | risk factors associated with development of dengue haemorrhagic fever or dengue shock syndrome in adults in hospital tengku ampuan afzan kuantan |
| topic | R Medicine (General) RA Public aspects of medicine |
| url | http://irep.iium.edu.my/1126/ http://irep.iium.edu.my/1126/ http://irep.iium.edu.my/1126/1/Risk_Factors_Associated_with_Development_of_Dengue.pdf |