Serum mesothelin for early detection of asbestos-induced cancer malignant mesothelioma
Background: Malignant mesothelioma is an aggressive, almost uniformly fatal tumor, primarily caused by exposure to asbestos. Since the recent discovery that serum mesothelin is a sensitive and highly specific biomarker for mesothelioma, one of the key issues raised is whether mesothelin levels repre...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
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American Association for Cancer Research Inc
2010
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| Online Access: | http://hdl.handle.net/20.500.11937/9994 |
| _version_ | 1848746135652401152 |
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| author | Creaney, J. Olsen, N. Brims, Fraser Dick, I. Musk, A. De Klerk, N. Skates, S. Robinson, B. |
| author_facet | Creaney, J. Olsen, N. Brims, Fraser Dick, I. Musk, A. De Klerk, N. Skates, S. Robinson, B. |
| author_sort | Creaney, J. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Background: Malignant mesothelioma is an aggressive, almost uniformly fatal tumor, primarily caused by exposure to asbestos. Since the recent discovery that serum mesothelin is a sensitive and highly specific biomarker for mesothelioma, one of the key issues raised is whether mesothelin levels represent a useful screening test for asbestos-exposed at-risk individuals. In this study, soluble mesothelin was determined in sequential serum samples collected from asbestos-exposed individuals before the development of mesothelioma. Methods: Archival serum samples from 106 individuals who developed mesothelioma, 99 asbestosexposed individuals from the Wittenoom Cancer Surveillance Program, and 109 non-asbestos-exposed individuals from the Busselton Health Survey were identified. Serum mesothelin concentrations were determined using the MESOMARK assay. Results: Longitudinal mesothelin levels determined in healthy asbestos-exposed individuals over a period of 4 years were stable (Pearson's r = 0.96; P < 0.0001). There was no correlation between mesothelin concentration and cumulative asbestos exposure. Mesothelin concentrations were greater than the threshold value of 2.5 nmol/L in the penultimate serum sample before the diagnosis of mesothelioma in 17 of 106 people. Using an increase above the 95% confidence interval of the mean of a given individual's longitudinal mesothelin results, 33 of 82 individuals had increasing mesothelin levels before diagnosis. Conclusion: In a population with a high pretest probability of developing mesothelioma, the serum biomarker mesothelin is elevated in absolute terms in 15% and in relative terms in 40% of the group. Impact: Future studies examining a combination of biomarkers could improve sensitivity of screening. ©2010 AACR. |
| first_indexed | 2025-11-14T06:28:27Z |
| format | Journal Article |
| id | curtin-20.500.11937-9994 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:28:27Z |
| publishDate | 2010 |
| publisher | American Association for Cancer Research Inc |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-99942017-09-13T14:55:43Z Serum mesothelin for early detection of asbestos-induced cancer malignant mesothelioma Creaney, J. Olsen, N. Brims, Fraser Dick, I. Musk, A. De Klerk, N. Skates, S. Robinson, B. Background: Malignant mesothelioma is an aggressive, almost uniformly fatal tumor, primarily caused by exposure to asbestos. Since the recent discovery that serum mesothelin is a sensitive and highly specific biomarker for mesothelioma, one of the key issues raised is whether mesothelin levels represent a useful screening test for asbestos-exposed at-risk individuals. In this study, soluble mesothelin was determined in sequential serum samples collected from asbestos-exposed individuals before the development of mesothelioma. Methods: Archival serum samples from 106 individuals who developed mesothelioma, 99 asbestosexposed individuals from the Wittenoom Cancer Surveillance Program, and 109 non-asbestos-exposed individuals from the Busselton Health Survey were identified. Serum mesothelin concentrations were determined using the MESOMARK assay. Results: Longitudinal mesothelin levels determined in healthy asbestos-exposed individuals over a period of 4 years were stable (Pearson's r = 0.96; P < 0.0001). There was no correlation between mesothelin concentration and cumulative asbestos exposure. Mesothelin concentrations were greater than the threshold value of 2.5 nmol/L in the penultimate serum sample before the diagnosis of mesothelioma in 17 of 106 people. Using an increase above the 95% confidence interval of the mean of a given individual's longitudinal mesothelin results, 33 of 82 individuals had increasing mesothelin levels before diagnosis. Conclusion: In a population with a high pretest probability of developing mesothelioma, the serum biomarker mesothelin is elevated in absolute terms in 15% and in relative terms in 40% of the group. Impact: Future studies examining a combination of biomarkers could improve sensitivity of screening. ©2010 AACR. 2010 Journal Article http://hdl.handle.net/20.500.11937/9994 10.1158/1055-9965.EPI-10-0346 American Association for Cancer Research Inc unknown |
| spellingShingle | Creaney, J. Olsen, N. Brims, Fraser Dick, I. Musk, A. De Klerk, N. Skates, S. Robinson, B. Serum mesothelin for early detection of asbestos-induced cancer malignant mesothelioma |
| title | Serum mesothelin for early detection of asbestos-induced cancer malignant mesothelioma |
| title_full | Serum mesothelin for early detection of asbestos-induced cancer malignant mesothelioma |
| title_fullStr | Serum mesothelin for early detection of asbestos-induced cancer malignant mesothelioma |
| title_full_unstemmed | Serum mesothelin for early detection of asbestos-induced cancer malignant mesothelioma |
| title_short | Serum mesothelin for early detection of asbestos-induced cancer malignant mesothelioma |
| title_sort | serum mesothelin for early detection of asbestos-induced cancer malignant mesothelioma |
| url | http://hdl.handle.net/20.500.11937/9994 |