Polymorphism of sheep MHC Class IIb gene TAPASIN
The Major Histocompatibility Complex (MHC) is one of the most gene dense regions in the genome and studies in several species have shown significant associations between the MHC and disease. The endoplasmic reticular glycoprotein, tapasin, is involved in the MHC class I antigen presentation pathway....
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ELSEVIER
2010
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| Online Access: | http://hdl.handle.net/20.500.11937/9989 |
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| author | Siva Subramaniam, N. Morgan, Eleanor Lee, C. Wetherall, John Groth, David |
| author_facet | Siva Subramaniam, N. Morgan, Eleanor Lee, C. Wetherall, John Groth, David |
| author_sort | Siva Subramaniam, N. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | The Major Histocompatibility Complex (MHC) is one of the most gene dense regions in the genome and studies in several species have shown significant associations between the MHC and disease. The endoplasmic reticular glycoprotein, tapasin, is involved in the MHC class I antigen presentation pathway. Sheep TAPASIN is located in the class IIb region of the MHC. Sheep TAPASIN was subcloned from BAC and cosmid genomic clones and DNA sequenced. TAPASIN is 9549 bp in length and encodes a protein of 447 amino acids. The structure of sheep TAPASIN was similar to other mammals and consisted of eight exons with a distinctively larger intron between exon three and four. Sheep TAPASIN gene had high sequence identity with other mammalian TAPASINs. The TAPASIN gene sequence is conserved across many mammalian species and is possibly maintained through purifying selection with the average ratio of ds/dn of 3.9. Twenty-six SNPs in sheep TAPASIN were identified. |
| first_indexed | 2025-11-14T06:28:00Z |
| format | Journal Article |
| id | curtin-20.500.11937-9989 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:28:00Z |
| publishDate | 2010 |
| publisher | ELSEVIER |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-99892017-09-13T16:06:10Z Polymorphism of sheep MHC Class IIb gene TAPASIN Siva Subramaniam, N. Morgan, Eleanor Lee, C. Wetherall, John Groth, David polymorphism TAP-binding protein SNP TAPASIN sheep MHC The Major Histocompatibility Complex (MHC) is one of the most gene dense regions in the genome and studies in several species have shown significant associations between the MHC and disease. The endoplasmic reticular glycoprotein, tapasin, is involved in the MHC class I antigen presentation pathway. Sheep TAPASIN is located in the class IIb region of the MHC. Sheep TAPASIN was subcloned from BAC and cosmid genomic clones and DNA sequenced. TAPASIN is 9549 bp in length and encodes a protein of 447 amino acids. The structure of sheep TAPASIN was similar to other mammals and consisted of eight exons with a distinctively larger intron between exon three and four. Sheep TAPASIN gene had high sequence identity with other mammalian TAPASINs. The TAPASIN gene sequence is conserved across many mammalian species and is possibly maintained through purifying selection with the average ratio of ds/dn of 3.9. Twenty-six SNPs in sheep TAPASIN were identified. 2010 Journal Article http://hdl.handle.net/20.500.11937/9989 10.1016/j.vetimm.2010.04.018 ELSEVIER fulltext |
| spellingShingle | polymorphism TAP-binding protein SNP TAPASIN sheep MHC Siva Subramaniam, N. Morgan, Eleanor Lee, C. Wetherall, John Groth, David Polymorphism of sheep MHC Class IIb gene TAPASIN |
| title | Polymorphism of sheep MHC Class IIb gene TAPASIN |
| title_full | Polymorphism of sheep MHC Class IIb gene TAPASIN |
| title_fullStr | Polymorphism of sheep MHC Class IIb gene TAPASIN |
| title_full_unstemmed | Polymorphism of sheep MHC Class IIb gene TAPASIN |
| title_short | Polymorphism of sheep MHC Class IIb gene TAPASIN |
| title_sort | polymorphism of sheep mhc class iib gene tapasin |
| topic | polymorphism TAP-binding protein SNP TAPASIN sheep MHC |
| url | http://hdl.handle.net/20.500.11937/9989 |