Can skin exposure to sunlight prevent liver inflammation?
Liver inflammation contributes towards the pathology of non-alcoholic fatty liver disease (NAFLD). Here we discuss how skin exposure to sunlight may suppress liver inflammation and the severity of NAFLD. Following exposure to sunlight-derived ultraviolet radiation (UVR), the skin releases anti-infla...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
MDPI Publishing
2015
|
| Online Access: | http://hdl.handle.net/20.500.11937/9902 |
| _version_ | 1848746083717480448 |
|---|---|
| author | Gorman, S. Black, Lucinda Feelisch, M. Hart, P. Weller, R. |
| author_facet | Gorman, S. Black, Lucinda Feelisch, M. Hart, P. Weller, R. |
| author_sort | Gorman, S. |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Liver inflammation contributes towards the pathology of non-alcoholic fatty liver disease (NAFLD). Here we discuss how skin exposure to sunlight may suppress liver inflammation and the severity of NAFLD. Following exposure to sunlight-derived ultraviolet radiation (UVR), the skin releases anti-inflammatory mediators such as vitamin D and nitric oxide. Animal modeling studies suggest that exposure to UVR can prevent the development of NAFLD. Association studies also support a negative link between circulating 25-hydroxyvitamin D and NAFLD incidence or severity. Clinical trials are in their infancy and are yet to demonstrate a clear beneficial effect of vitamin D supplementation. There are a number of potentially interdependent mechanisms whereby vitamin D could dampen liver inflammation, by inhibiting hepatocyte apoptosis and liver fibrosis, modulating the gut microbiome and through altered production and transport of bile acids. While there has been a focus on vitamin D, other mediators induced by sun exposure, such as nitric oxide may also play important roles in curtailing liver inflammation. |
| first_indexed | 2025-11-14T06:27:37Z |
| format | Journal Article |
| id | curtin-20.500.11937-9902 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T06:27:37Z |
| publishDate | 2015 |
| publisher | MDPI Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-99022017-09-13T14:50:55Z Can skin exposure to sunlight prevent liver inflammation? Gorman, S. Black, Lucinda Feelisch, M. Hart, P. Weller, R. Liver inflammation contributes towards the pathology of non-alcoholic fatty liver disease (NAFLD). Here we discuss how skin exposure to sunlight may suppress liver inflammation and the severity of NAFLD. Following exposure to sunlight-derived ultraviolet radiation (UVR), the skin releases anti-inflammatory mediators such as vitamin D and nitric oxide. Animal modeling studies suggest that exposure to UVR can prevent the development of NAFLD. Association studies also support a negative link between circulating 25-hydroxyvitamin D and NAFLD incidence or severity. Clinical trials are in their infancy and are yet to demonstrate a clear beneficial effect of vitamin D supplementation. There are a number of potentially interdependent mechanisms whereby vitamin D could dampen liver inflammation, by inhibiting hepatocyte apoptosis and liver fibrosis, modulating the gut microbiome and through altered production and transport of bile acids. While there has been a focus on vitamin D, other mediators induced by sun exposure, such as nitric oxide may also play important roles in curtailing liver inflammation. 2015 Journal Article http://hdl.handle.net/20.500.11937/9902 10.3390/nu7053219 MDPI Publishing fulltext |
| spellingShingle | Gorman, S. Black, Lucinda Feelisch, M. Hart, P. Weller, R. Can skin exposure to sunlight prevent liver inflammation? |
| title | Can skin exposure to sunlight prevent liver inflammation? |
| title_full | Can skin exposure to sunlight prevent liver inflammation? |
| title_fullStr | Can skin exposure to sunlight prevent liver inflammation? |
| title_full_unstemmed | Can skin exposure to sunlight prevent liver inflammation? |
| title_short | Can skin exposure to sunlight prevent liver inflammation? |
| title_sort | can skin exposure to sunlight prevent liver inflammation? |
| url | http://hdl.handle.net/20.500.11937/9902 |