The application of novel nano-capsules containing probucol-lithocholic acid to counteract oxidative stress
This thesis developed bile acid-based polymeric nanoparticles to enhance targeted delivery of probucol for oxidative stress-induced hearing and retinal damage. The formulation improved cellular uptake and sustained release while overcoming biological barriers. In vitro and in vivo studies confirmed...
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| Format: | Thesis |
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Curtin University
2025
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| Online Access: | http://hdl.handle.net/20.500.11937/98126 |
| _version_ | 1848766366970019840 |
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| author | Wagle, Susbin Raj |
| author_facet | Wagle, Susbin Raj |
| author_sort | Wagle, Susbin Raj |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | This thesis developed bile acid-based polymeric nanoparticles to enhance targeted delivery of probucol for oxidative stress-induced hearing and retinal damage. The formulation improved cellular uptake and sustained release while overcoming biological barriers. In vitro and in vivo studies confirmed the potent antioxidant activity, reduction of oxidative markers, and activation of protective cellular pathways. This innovative delivery platform offers a promising approach for addressing neurosensory complications, including sensorineural hearing loss and retinal degenerative diseases. |
| first_indexed | 2025-11-14T11:50:01Z |
| format | Thesis |
| id | curtin-20.500.11937-98126 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:50:01Z |
| publishDate | 2025 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-981262025-07-22T01:22:32Z The application of novel nano-capsules containing probucol-lithocholic acid to counteract oxidative stress Wagle, Susbin Raj This thesis developed bile acid-based polymeric nanoparticles to enhance targeted delivery of probucol for oxidative stress-induced hearing and retinal damage. The formulation improved cellular uptake and sustained release while overcoming biological barriers. In vitro and in vivo studies confirmed the potent antioxidant activity, reduction of oxidative markers, and activation of protective cellular pathways. This innovative delivery platform offers a promising approach for addressing neurosensory complications, including sensorineural hearing loss and retinal degenerative diseases. 2025 Thesis http://hdl.handle.net/20.500.11937/98126 Curtin University restricted |
| spellingShingle | Wagle, Susbin Raj The application of novel nano-capsules containing probucol-lithocholic acid to counteract oxidative stress |
| title | The application of novel nano-capsules containing probucol-lithocholic acid to counteract oxidative stress |
| title_full | The application of novel nano-capsules containing probucol-lithocholic acid to counteract oxidative stress |
| title_fullStr | The application of novel nano-capsules containing probucol-lithocholic acid to counteract oxidative stress |
| title_full_unstemmed | The application of novel nano-capsules containing probucol-lithocholic acid to counteract oxidative stress |
| title_short | The application of novel nano-capsules containing probucol-lithocholic acid to counteract oxidative stress |
| title_sort | application of novel nano-capsules containing probucol-lithocholic acid to counteract oxidative stress |
| url | http://hdl.handle.net/20.500.11937/98126 |