Design and Synthesis of Novel Cyclic Indole Amides for Versatile Biological Applications
Indoles are a widely utilised chemotype in nature and medicinal chemistry, in which several of these compounds are cyclic or contain amide functionalisation. This thesis describes the exploration and synthesis of conformationally restricted, cyclic indole amides and their versatile biological applic...
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| Format: | Thesis |
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Curtin University
2024
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| Online Access: | http://hdl.handle.net/20.500.11937/98073 |
| _version_ | 1848766358039298048 |
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| author | Hamilton, Alexander John |
| author_facet | Hamilton, Alexander John |
| author_sort | Hamilton, Alexander John |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Indoles are a widely utilised chemotype in nature and medicinal chemistry, in which several of these compounds are cyclic or contain amide functionalisation. This thesis describes the exploration and synthesis of conformationally restricted, cyclic indole amides and their versatile biological applications. Several synthetic routes and techniques were utilised to produce over 85 novel compounds with selected final compounds biologically assessed as cannabinoid ligands, antitumour agents and antiplasmodial compounds. |
| first_indexed | 2025-11-14T11:49:52Z |
| format | Thesis |
| id | curtin-20.500.11937-98073 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:49:52Z |
| publishDate | 2024 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-980732025-07-11T05:53:19Z Design and Synthesis of Novel Cyclic Indole Amides for Versatile Biological Applications Hamilton, Alexander John Indoles are a widely utilised chemotype in nature and medicinal chemistry, in which several of these compounds are cyclic or contain amide functionalisation. This thesis describes the exploration and synthesis of conformationally restricted, cyclic indole amides and their versatile biological applications. Several synthetic routes and techniques were utilised to produce over 85 novel compounds with selected final compounds biologically assessed as cannabinoid ligands, antitumour agents and antiplasmodial compounds. 2024 Thesis http://hdl.handle.net/20.500.11937/98073 Curtin University restricted |
| spellingShingle | Hamilton, Alexander John Design and Synthesis of Novel Cyclic Indole Amides for Versatile Biological Applications |
| title | Design and Synthesis of Novel Cyclic Indole Amides for Versatile Biological Applications |
| title_full | Design and Synthesis of Novel Cyclic Indole Amides for Versatile Biological Applications |
| title_fullStr | Design and Synthesis of Novel Cyclic Indole Amides for Versatile Biological Applications |
| title_full_unstemmed | Design and Synthesis of Novel Cyclic Indole Amides for Versatile Biological Applications |
| title_short | Design and Synthesis of Novel Cyclic Indole Amides for Versatile Biological Applications |
| title_sort | design and synthesis of novel cyclic indole amides for versatile biological applications |
| url | http://hdl.handle.net/20.500.11937/98073 |