Quantitative Analysis of Early-stage Transient Adhesion Between Bioactive Glass and Planktonic Bacteria
Bacterial infections associated with implants continue to present major clinical challenges. This study examines the interactions between planktonic bacteria and bioactive glass 58S using Atomic Force Microscopy (AFM), focusing on the influence of crystallinity and composition on antibacterial perfo...
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| Format: | Thesis |
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Curtin University
2025
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| Online Access: | http://hdl.handle.net/20.500.11937/98067 |
| _version_ | 1848766356505231360 |
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| author | Gour, Shivani Shailendrasingh |
| author_facet | Gour, Shivani Shailendrasingh |
| author_sort | Gour, Shivani Shailendrasingh |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Bacterial infections associated with implants continue to present major clinical challenges. This study examines the interactions between planktonic bacteria and bioactive glass 58S using Atomic Force Microscopy (AFM), focusing on the influence of crystallinity and composition on antibacterial performance. Amorphous 58S synthesized via the sol-gel method demonstrated superior antibacterial efficacy compared to its semi-crystalline counterparts. The incorporation of silver nanoparticles into 58S further enhanced antibacterial activity, particularly against E. coli. AFM revealed stronger adhesion forces for E. coli compared to S. aureus, with irreversible attachment beginning within one second. The composition also exhibited excellent bioactivity, making it suitable for implant coatings and porous scaffolds. |
| first_indexed | 2025-11-14T11:49:51Z |
| format | Thesis |
| id | curtin-20.500.11937-98067 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:49:51Z |
| publishDate | 2025 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-980672025-07-11T03:53:03Z Quantitative Analysis of Early-stage Transient Adhesion Between Bioactive Glass and Planktonic Bacteria Gour, Shivani Shailendrasingh Bacterial infections associated with implants continue to present major clinical challenges. This study examines the interactions between planktonic bacteria and bioactive glass 58S using Atomic Force Microscopy (AFM), focusing on the influence of crystallinity and composition on antibacterial performance. Amorphous 58S synthesized via the sol-gel method demonstrated superior antibacterial efficacy compared to its semi-crystalline counterparts. The incorporation of silver nanoparticles into 58S further enhanced antibacterial activity, particularly against E. coli. AFM revealed stronger adhesion forces for E. coli compared to S. aureus, with irreversible attachment beginning within one second. The composition also exhibited excellent bioactivity, making it suitable for implant coatings and porous scaffolds. 2025 Thesis http://hdl.handle.net/20.500.11937/98067 Curtin University fulltext |
| spellingShingle | Gour, Shivani Shailendrasingh Quantitative Analysis of Early-stage Transient Adhesion Between Bioactive Glass and Planktonic Bacteria |
| title | Quantitative Analysis of Early-stage Transient
Adhesion Between Bioactive Glass and
Planktonic Bacteria |
| title_full | Quantitative Analysis of Early-stage Transient
Adhesion Between Bioactive Glass and
Planktonic Bacteria |
| title_fullStr | Quantitative Analysis of Early-stage Transient
Adhesion Between Bioactive Glass and
Planktonic Bacteria |
| title_full_unstemmed | Quantitative Analysis of Early-stage Transient
Adhesion Between Bioactive Glass and
Planktonic Bacteria |
| title_short | Quantitative Analysis of Early-stage Transient
Adhesion Between Bioactive Glass and
Planktonic Bacteria |
| title_sort | quantitative analysis of early-stage transient
adhesion between bioactive glass and
planktonic bacteria |
| url | http://hdl.handle.net/20.500.11937/98067 |