The Role of Pigment Epithelium-derived Factor in Breast
Cancer Cell Metabolism

QR Code

The Role of Pigment Epithelium-derived Factor in Breast Cancer Cell Metabolism

The thesis investigates the potential of PEDF as a novel regulator of metabolism and metastasis in breast cancer. Findings highlight PEDF's critical role in modulating glucose metabolism, mitochondrial function, and metastatic progression, proposing it as a promising therapeutic target. Additio...

Full description

Bibliographic Details
Main Author:	Abooshahab, Raziyeh
Format:	Thesis
Published:	Curtin University 2025
Online Access:	http://hdl.handle.net/20.500.11937/98030

Similar Items

Pigment epithelium-derived factor and menopause in metastatic breast cancer
by: Brook, Naomi Louise
Published: (2022)

Pigment Epithelium-Derived Factor: Chemistry, Structure, Biology, and Applications
by: Becerra, S.P., et al.
Published: (2012)

Pigment Epithelium-derived Factor and Insulin Crosstalk in Skeletal Muscle Biology
by: Carnagarin, Revathy
Published: (2017)

Potential of pigment epithelium-derived factor (PEDF) as a bone regenerative biopharmaceutical
by: Lee, P., et al.
Published: (2016)

Stimulation of bone regeneration with pigment epithelium-derived factor microparticles: Evidence in silico, in vitro and in vivo
by: Lee, P., et al.
Published: (2016)

Reduction in tumour cell invasion by pigment epithelium-derived factor is mediated by membrane type-1 matrix metalloproteinase downregulation
by: Filiz, G., et al.
Published: (2012)

Pigment epithelium-derived factor (PEDF) regulates metabolism and insulin secretion from a clonal rat pancreatic beta cell line BRIN-BD11 and mouse islets
by: Chen, Y., et al.
Published: (2016)

Pigment epithelium-derived factor: a key mediator in bone homeostasis and potential for bone regenerative therapy
by: Baxter-Holland, M., et al.
Published: (2018)

Pigment Epithelium-Derived Factor as an Impending Therapeutic Agent Against Vascular Epithelial Growth Factor-Driven Tumor-Angiogenesis
by: Manalo, K., et al.
Published: (2011)

Insulin antagonises pigment epithelium-derived factor (PEDF)-induced modulation of lineage commitment of myocytes and heterotrophic ossification
by: Carnagarin, R., et al.
Published: (2018)

Pigment epithelium-derived factor as a natural matrix metalloproteinase inhibitor: a comparison with classical matrix metalloproteinase inhibitors used for cancer treatment
by: Alcantara, M., et al.
Published: (2014)

Pigment epithelium-derived factor as an anticancer drug and new treatment methods following the discovery of its receptors: a patent perspective
by: Manalo, K., et al.
Published: (2011)

Pigment epithelium-derived factor stimulates skeletal muscle glycolytic activity through NADPH oxidase-dependent reactive oxygen species production
by: Carnagarin, R., et al.
Published: (2016)

MicroRNAs and their role in breast cancer metabolism (review)
by: Lee, Wen Xuan, et al.
Published: (2024)

Pigment epithelium-derived factor upregulates collagen I and downregulates matrix metalloproteinase 2 in osteosarcoma cells, and colocalises to collagen I and heat shock protein 47 in fetal and adult bone
by: Alcantara, M., et al.
Published: (2014)

Effect of transforming growth factor β2 on oestrogen metabolism in the MCF-7 breast cancer cell line
by: Erbas, Hakan, et al.
Published: (2000)

The role of strobilanthes crispus active fraction (f3) on glucose metabolism of MDA-MB-231 breast cancer cell line
by: Muhammad, Siti Nur Hasyila
Published: (2023)

Genotypic and metabolic phenotype changes in breast cells using gold‐based compound cancer treatment
by: Yu, Richard Ming Chuan
Published: (2018)

Elucidation of Pigment Biosynthetic Pathways – Towards Integration of Metabolomics, Metabolic Flux Analysis, and Metabolic Engineering
by: Kamarudin, Kamarul Rahim, et al.
Published: (2012)

Differential expression of a subset of ribosomal protein genes in cell lines derived from human nasopharyngeal epithelium
by: Ui, Edmund Hang Sim, et al.
Published: (2010)

Microbial production of food grade pigments – screening and metabolic pathway analysis
by: Kamarudin, Kamarul Rahim
Published: (2009)

Cockle shell‑derived aragonite calcium carbonate nanoparticle for targeting cancer and breast cancer stem cells
by: Ibiyeye, Kehinde Muibat, et al.
Published: (2020)

Effect of transforming growth factor-beta1 on oestrogen metabolism in MCF-7 and MDA-MB-231 breast cancer cell lines.
by: Ee, Y.S., et al.
Published: (1999)

Characterization of side population cells from human airway epithelium
by: Hackett, T.L., et al.
Published: (2008)

Gene expression analysis of the ribosomal protein gene, RPL 14 in cell lines derived from human nasopharyngeal epithelium
by: Vasudevan, Lisha
Published: (2015)

Altered glutamine metabolism in breast cancer: subtype dependencies and alternative adaptations
by: El Ansari, Rokaya, et al.
Published: (2017)

Role of antioxidants in the pigmentation of ornamental fishes
by: Yuli, A., et al.
Published: (2024)

Targeting energy metabolism to eliminate cancer cells
by: Shahruzaman, Shazwin Hani, et al.
Published: (2018)

Molecular modelling of berberine derivatives as inhibitors of oncogenic signalling pathways in breast cancer cell lines
by: Kaboli, Parham Jabbarzadeh
Published: (2017)

Effect of transforming growth factor-β1, insulin-like growth factor-I and insulin-like growth factor-II on cell growth and oestrogen metabolism in human breast cancer cell lines
by: Wong, Shew Fung, et al.
Published: (2001)

Anti-Proliferation Effects of Benzimidazole Derivatives on HCT-116 Colon Cancer and MCF-7 Breast Cancer Cell Lines
by: Al-Douh, Mohammed Hadi, et al.
Published: (2012)

The role of mesenchymal cell-mediated paracrine signalling in breast cancer progression and metastasis
by: Pal, Amarnath
Published: (2019)

The role of HIF-1α and VGSCs in influencing metastasis of breast cancer cells
by: Dewadas, Hemaniswarri Dewi
Published: (2018)

The role of calpain/calpastatin in breast cancer
by: Cook, Liam
Published: (2024)

Thiazolidinediones Pretreated Bone Marrow-Derived Mesenchymal Stem Cells As An Anti-Cancer Approach Against Mcf-7 Breast Cancer Cell Line
by: Lim, Shern Kwok
Published: (2022)

Cancer stem cell metabolism: A potential target for cancer therapy
by: Deshmukh, A., et al.
Published: (2016)

In vitro antiproliferative effects and underlying mechanismds of bismuth dithiocarbamate derivatives against breast cancer cell line
by: Chan, Pit Foong
Published: (2019)

Circulating stem cells engraft the bronchial epithelium in humans after lung transplantation
by: May, L., et al.
Published: (2008)

The Effects Of Aerosol-Based Cell Delivery Technique On The Regeneration And Repair Of Airway Epithelium
by: ., Egi Kardia
Published: (2017)

Comparative metabolic changes of tissues and plasma in breast cancer patients / Erda Syerena Rosli
by: Rosli, Erda Syerena
Published: (2015)