Decoding the genetic interplay between stress and Alzheimer’s disease.
Alzheimer’s disease (AD) has a complex aetiology involving genetic and environmental factors. This thesis explores how genetic and epigenetic variation in stress-related genes influences AD risk and progression. Key findings include associations between genetic variants, DNA methylation, and AD-rela...
| Main Author: | |
|---|---|
| Format: | Thesis |
| Published: |
Curtin University
2024
|
| Online Access: | http://hdl.handle.net/20.500.11937/97691 |
| _version_ | 1848766304015613952 |
|---|---|
| author | Milligan Armstrong, Ayeisha Grace |
| author_facet | Milligan Armstrong, Ayeisha Grace |
| author_sort | Milligan Armstrong, Ayeisha Grace |
| building | Curtin Institutional Repository |
| collection | Online Access |
| description | Alzheimer’s disease (AD) has a complex aetiology involving genetic and environmental factors. This thesis explores how genetic and epigenetic variation in stress-related genes influences AD risk and progression. Key findings include associations between genetic variants, DNA methylation, and AD-related phenotypes, involving cognition and brain volume changes. Additionally, shared genetic architectures and biological pathways underpinning stress-traits and AD were identified. These findings will assist in the identification of potential therapeutic targets and advancing precision medicine approaches. |
| first_indexed | 2025-11-14T11:49:01Z |
| format | Thesis |
| id | curtin-20.500.11937-97691 |
| institution | Curtin University Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:49:01Z |
| publishDate | 2024 |
| publisher | Curtin University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | curtin-20.500.11937-976912025-05-06T02:08:44Z Decoding the genetic interplay between stress and Alzheimer’s disease. Milligan Armstrong, Ayeisha Grace Alzheimer’s disease (AD) has a complex aetiology involving genetic and environmental factors. This thesis explores how genetic and epigenetic variation in stress-related genes influences AD risk and progression. Key findings include associations between genetic variants, DNA methylation, and AD-related phenotypes, involving cognition and brain volume changes. Additionally, shared genetic architectures and biological pathways underpinning stress-traits and AD were identified. These findings will assist in the identification of potential therapeutic targets and advancing precision medicine approaches. 2024 Thesis http://hdl.handle.net/20.500.11937/97691 Curtin University restricted |
| spellingShingle | Milligan Armstrong, Ayeisha Grace Decoding the genetic interplay between stress and Alzheimer’s disease. |
| title | Decoding the genetic interplay between stress and Alzheimer’s disease. |
| title_full | Decoding the genetic interplay between stress and Alzheimer’s disease. |
| title_fullStr | Decoding the genetic interplay between stress and Alzheimer’s disease. |
| title_full_unstemmed | Decoding the genetic interplay between stress and Alzheimer’s disease. |
| title_short | Decoding the genetic interplay between stress and Alzheimer’s disease. |
| title_sort | decoding the genetic interplay between stress and alzheimer’s disease. |
| url | http://hdl.handle.net/20.500.11937/97691 |